Antinociceptive effects of systemic lidocaine: Involvement of the spinal glycinergic system

Beside their action on voltage-gated Na + channels, local anesthetics are known to exert a variety of effects via alternative mechanisms. The antinociceptive effect of lidocaine is well documented, yet the exact mechanism is not fully understood. Whether glycinergic mechanisms, which play a pivotal...

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Veröffentlicht in:	European journal of pharmacology 2009-06, Vol.613 (1), p.68-73
Hauptverfasser:	Muth-Selbach, Uta, Hermanns, Henning, Stegmann, Jens Ulrich, Kollosche, Kathrin, Freynhagen, Rainer, Bauer, Inge, Lipfert, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Analgesics - pharmacology Analgesics - therapeutic use Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Binding Sites Biological and medical sciences Chronic constriction injury Formalin test Glycine Glycine - pharmacology Glycine Agents - administration & dosage Glycine Agents - pharmacology Glycine Agents - therapeutic use Lidocaine Lidocaine - administration & dosage Lidocaine - pharmacology Lidocaine - therapeutic use Medical sciences Neuropharmacology Nociception Organophosphonates - metabolism Organophosphonates - pharmacology Pain - drug therapy Pain - metabolism Pathological pain Pharmacology. Drug treatments Quinoxalines - metabolism Quinoxalines - pharmacology Rats Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Serine - pharmacology Spinal Cord - drug effects Spinal Cord - metabolism Substrate Specificity Synaptic Transmission - drug effects
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