Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival
Background and Purpose : Uncontrolled growth, invasion and distant spread are the characteristics of neoplastic cells. Changes in adhesion molecule expression, such as loss of expression, de novo expression or functional alterations, can be observed in each of these steps. The aim of the present wor...
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| Veröffentlicht in: | Journal of Egyptian National Cancer Institute 2004-12, Vol.16 (4), p.244-251 |
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| creator | Aboul-Enein, Mostafa El-Sayed, Ghada M El-Maghraby, Shreen Abd-Elatif, Nahla A B Abd Elwahab, Gehan A Elbasmy, Amany A |
| description | Background and Purpose : Uncontrolled growth,
invasion and distant spread are the characteristics of
neoplastic cells. Changes in adhesion molecule expression,
such as loss of expression, de novo expression or functional
alterations, can be observed in each of these steps. The
aim of the present work was to study the expression of
two adhesion molecules [standard CD44 (CD44s) and
intercellular adhesion molecule-1 (ICAM-1)] and the
soluble form of ICAM-1 (sICAM-1) in adult disseminated
non-Hodgkin's lymphoma (D-NHL) and to correlate the
findings with overall survival.
Patients and Methods : The expression of CD44s and
ICAM-1 adhesion molecules and the level of sICAM-1
were studied in 34 cases of (D-NHL). They included : 13
cases of lymphoblastic lymphoma (LBL), 5 cases of
Burkitt's lymphoma (BL), one case of diffuse large cell
lymphoma (DLCL), 14 cases of small lymphocytic lymphoma
(SLL), one case of mantle cell lymphoma (MCL).
Ten apparently healthy individuals were taken as a control
group. CD44s expression was evaluated by direct immunofluorescence,
ICAM-1 by immunoperoxidase on cytopreps
and serum level of sICAM-1 by ELISA.
Results : ICAM-1 was positive in 6/34 cases (17.6%)
of D-NHL. ICAM-1 was expressed in 2/15 (13.3%) of
low-grade NHL and 4/19 (21%) of high-grade lymphoma
with no significant difference between the two groups
(p=0.6). CD44s was expressed in 13/34 cases (38.2%) of
D-NHL; in 4/15 (26.6%) of low grade NHL and 9/19
(47.3%) of high grade lymphoma with no significant
difference between the two groups (p=0.2). The serum
levels of sICAM-1 were elevated in all patients with DNHL
compared to healthy controls with a statistically
significant difference (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67310818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67310818</sourcerecordid><originalsourceid>FETCH-LOGICAL-e752-1960b0bd51ced2d5c6a38b05ab65fd44cd2478b3435713351103e2e5a40554353</originalsourceid><addsrcrecordid>eNo90M1Kw0AQB_AgitXqG4jMyQ9oYDeb3aTepKgtFLz0XjbZqV3dj7qbRPs8vqgprZ5mGH7MDP-j5IyKskjH47E47ntKSUqYyAbJeYzvhAhBCn6aDKigVHCSnSU_M9dgqNGY1sgAUq0xau_AeoN1azClcKdraVN6P4Ja5XkE_N4EjDs1AukURAytBYMdGvAriHsO2oHSMaLVTjaowHmXTr16-9DuNoLZ2s3aWwkPUPsQ0Mhmd_ZLN2vwHQZpDMQ2dLqT5iI5WUkT8fJQh8ni-Wkxmabz15fZ5HGeYsGzlI4FqUilOK1RZYrXQrKyIlxWgq_6x2uV5UVZsZzxgjLG-2wYZshlTjjvh2yY3OzXboL_bDE2S6vjLhnp0LdxKQpGSUnLHl4fYFtZVMtN0FaG7fIv1R5c7QH2c1zJf8GynAv2C09Bfuc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67310818</pqid></control><display><type>article</type><title>Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Aboul-Enein, Mostafa ; El-Sayed, Ghada M ; El-Maghraby, Shreen ; Abd-Elatif, Nahla A B ; Abd Elwahab, Gehan A ; Elbasmy, Amany A</creator><creatorcontrib>Aboul-Enein, Mostafa ; El-Sayed, Ghada M ; El-Maghraby, Shreen ; Abd-Elatif, Nahla A B ; Abd Elwahab, Gehan A ; Elbasmy, Amany A</creatorcontrib><description>Background and Purpose : Uncontrolled growth,
invasion and distant spread are the characteristics of
neoplastic cells. Changes in adhesion molecule expression,
such as loss of expression, de novo expression or functional
alterations, can be observed in each of these steps. The
aim of the present work was to study the expression of
two adhesion molecules [standard CD44 (CD44s) and
intercellular adhesion molecule-1 (ICAM-1)] and the
soluble form of ICAM-1 (sICAM-1) in adult disseminated
non-Hodgkin's lymphoma (D-NHL) and to correlate the
findings with overall survival.
Patients and Methods : The expression of CD44s and
ICAM-1 adhesion molecules and the level of sICAM-1
were studied in 34 cases of (D-NHL). They included : 13
cases of lymphoblastic lymphoma (LBL), 5 cases of
Burkitt's lymphoma (BL), one case of diffuse large cell
lymphoma (DLCL), 14 cases of small lymphocytic lymphoma
(SLL), one case of mantle cell lymphoma (MCL).
Ten apparently healthy individuals were taken as a control
group. CD44s expression was evaluated by direct immunofluorescence,
ICAM-1 by immunoperoxidase on cytopreps
and serum level of sICAM-1 by ELISA.
Results : ICAM-1 was positive in 6/34 cases (17.6%)
of D-NHL. ICAM-1 was expressed in 2/15 (13.3%) of
low-grade NHL and 4/19 (21%) of high-grade lymphoma
with no significant difference between the two groups
(p=0.6). CD44s was expressed in 13/34 cases (38.2%) of
D-NHL; in 4/15 (26.6%) of low grade NHL and 9/19
(47.3%) of high grade lymphoma with no significant
difference between the two groups (p=0.2). The serum
levels of sICAM-1 were elevated in all patients with DNHL
compared to healthy controls with a statistically
significant difference (p<0.001), (median 1160 ng/ml,
range from 150 to 2500 ng/ml, and 375 ng/ml, range from
270 to 620 ng/ml, respectively). The median of sICAM-
1 in patients with high-grade D-NHL was significantly
(p=0.006) lower than that of those with low-grade D-NHL
(median 890 ng/ml, range from 150 to 1540 ng/ml and
1440 ng/ml, range from 380 to 2500 ng/ml respectively). The median follow-up duration for all patients was 18
months. No statistical significant difference was achieved
(p=0.8) on comparing overall survival pattern between
D-NHL lymphoma patients with positive or negative
expression of ICAM-1 or sCD44 expression. Also, no
statistically significant difference (p=0.9) was found
between patients with sICAM (above and below 600
ng/ml) at 18 months from diagnosis.
Conclusion : There is a marked heterogeneity in cell
adhesion molecule (CAM) expression in NHL and this
may correlate with degree of differentiation of malignant
lymphocytes. However the exact significance of these
findings will require functional studies to determine the
role of these CAMs in each subtype of NHL.</description><identifier>ISSN: 1110-0362</identifier><identifier>EISSN: 1687-9996</identifier><identifier>PMID: 16116502</identifier><language>eng</language><publisher>Cairo, Egypt: Cairo University, National Cancer Institute</publisher><subject>Cell adhesion molecules ; Lymphomas ; الأورام ; الجزيئات الحيوية</subject><ispartof>Journal of Egyptian National Cancer Institute, 2004-12, Vol.16 (4), p.244-251</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16116502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aboul-Enein, Mostafa</creatorcontrib><creatorcontrib>El-Sayed, Ghada M</creatorcontrib><creatorcontrib>El-Maghraby, Shreen</creatorcontrib><creatorcontrib>Abd-Elatif, Nahla A B</creatorcontrib><creatorcontrib>Abd Elwahab, Gehan A</creatorcontrib><creatorcontrib>Elbasmy, Amany A</creatorcontrib><title>Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival</title><title>Journal of Egyptian National Cancer Institute</title><addtitle>J Egypt Natl Canc Inst</addtitle><description>Background and Purpose : Uncontrolled growth,
invasion and distant spread are the characteristics of
neoplastic cells. Changes in adhesion molecule expression,
such as loss of expression, de novo expression or functional
alterations, can be observed in each of these steps. The
aim of the present work was to study the expression of
two adhesion molecules [standard CD44 (CD44s) and
intercellular adhesion molecule-1 (ICAM-1)] and the
soluble form of ICAM-1 (sICAM-1) in adult disseminated
non-Hodgkin's lymphoma (D-NHL) and to correlate the
findings with overall survival.
Patients and Methods : The expression of CD44s and
ICAM-1 adhesion molecules and the level of sICAM-1
were studied in 34 cases of (D-NHL). They included : 13
cases of lymphoblastic lymphoma (LBL), 5 cases of
Burkitt's lymphoma (BL), one case of diffuse large cell
lymphoma (DLCL), 14 cases of small lymphocytic lymphoma
(SLL), one case of mantle cell lymphoma (MCL).
Ten apparently healthy individuals were taken as a control
group. CD44s expression was evaluated by direct immunofluorescence,
ICAM-1 by immunoperoxidase on cytopreps
and serum level of sICAM-1 by ELISA.
Results : ICAM-1 was positive in 6/34 cases (17.6%)
of D-NHL. ICAM-1 was expressed in 2/15 (13.3%) of
low-grade NHL and 4/19 (21%) of high-grade lymphoma
with no significant difference between the two groups
(p=0.6). CD44s was expressed in 13/34 cases (38.2%) of
D-NHL; in 4/15 (26.6%) of low grade NHL and 9/19
(47.3%) of high grade lymphoma with no significant
difference between the two groups (p=0.2). The serum
levels of sICAM-1 were elevated in all patients with DNHL
compared to healthy controls with a statistically
significant difference (p<0.001), (median 1160 ng/ml,
range from 150 to 2500 ng/ml, and 375 ng/ml, range from
270 to 620 ng/ml, respectively). The median of sICAM-
1 in patients with high-grade D-NHL was significantly
(p=0.006) lower than that of those with low-grade D-NHL
(median 890 ng/ml, range from 150 to 1540 ng/ml and
1440 ng/ml, range from 380 to 2500 ng/ml respectively). The median follow-up duration for all patients was 18
months. No statistical significant difference was achieved
(p=0.8) on comparing overall survival pattern between
D-NHL lymphoma patients with positive or negative
expression of ICAM-1 or sCD44 expression. Also, no
statistically significant difference (p=0.9) was found
between patients with sICAM (above and below 600
ng/ml) at 18 months from diagnosis.
Conclusion : There is a marked heterogeneity in cell
adhesion molecule (CAM) expression in NHL and this
may correlate with degree of differentiation of malignant
lymphocytes. However the exact significance of these
findings will require functional studies to determine the
role of these CAMs in each subtype of NHL.</description><subject>Cell adhesion molecules</subject><subject>Lymphomas</subject><subject>الأورام</subject><subject>الجزيئات الحيوية</subject><issn>1110-0362</issn><issn>1687-9996</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNo90M1Kw0AQB_AgitXqG4jMyQ9oYDeb3aTepKgtFLz0XjbZqV3dj7qbRPs8vqgprZ5mGH7MDP-j5IyKskjH47E47ntKSUqYyAbJeYzvhAhBCn6aDKigVHCSnSU_M9dgqNGY1sgAUq0xau_AeoN1azClcKdraVN6P4Ja5XkE_N4EjDs1AukURAytBYMdGvAriHsO2oHSMaLVTjaowHmXTr16-9DuNoLZ2s3aWwkPUPsQ0Mhmd_ZLN2vwHQZpDMQ2dLqT5iI5WUkT8fJQh8ni-Wkxmabz15fZ5HGeYsGzlI4FqUilOK1RZYrXQrKyIlxWgq_6x2uV5UVZsZzxgjLG-2wYZshlTjjvh2yY3OzXboL_bDE2S6vjLhnp0LdxKQpGSUnLHl4fYFtZVMtN0FaG7fIv1R5c7QH2c1zJf8GynAv2C09Bfuc</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Aboul-Enein, Mostafa</creator><creator>El-Sayed, Ghada M</creator><creator>El-Maghraby, Shreen</creator><creator>Abd-Elatif, Nahla A B</creator><creator>Abd Elwahab, Gehan A</creator><creator>Elbasmy, Amany A</creator><general>Cairo University, National Cancer Institute</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival</title><author>Aboul-Enein, Mostafa ; El-Sayed, Ghada M ; El-Maghraby, Shreen ; Abd-Elatif, Nahla A B ; Abd Elwahab, Gehan A ; Elbasmy, Amany A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e752-1960b0bd51ced2d5c6a38b05ab65fd44cd2478b3435713351103e2e5a40554353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Cell adhesion molecules</topic><topic>Lymphomas</topic><topic>الأورام</topic><topic>الجزيئات الحيوية</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aboul-Enein, Mostafa</creatorcontrib><creatorcontrib>El-Sayed, Ghada M</creatorcontrib><creatorcontrib>El-Maghraby, Shreen</creatorcontrib><creatorcontrib>Abd-Elatif, Nahla A B</creatorcontrib><creatorcontrib>Abd Elwahab, Gehan A</creatorcontrib><creatorcontrib>Elbasmy, Amany A</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Egyptian National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aboul-Enein, Mostafa</au><au>El-Sayed, Ghada M</au><au>El-Maghraby, Shreen</au><au>Abd-Elatif, Nahla A B</au><au>Abd Elwahab, Gehan A</au><au>Elbasmy, Amany A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival</atitle><jtitle>Journal of Egyptian National Cancer Institute</jtitle><addtitle>J Egypt Natl Canc Inst</addtitle><date>2004-12</date><risdate>2004</risdate><volume>16</volume><issue>4</issue><spage>244</spage><epage>251</epage><pages>244-251</pages><issn>1110-0362</issn><eissn>1687-9996</eissn><abstract>Background and Purpose : Uncontrolled growth,
invasion and distant spread are the characteristics of
neoplastic cells. Changes in adhesion molecule expression,
such as loss of expression, de novo expression or functional
alterations, can be observed in each of these steps. The
aim of the present work was to study the expression of
two adhesion molecules [standard CD44 (CD44s) and
intercellular adhesion molecule-1 (ICAM-1)] and the
soluble form of ICAM-1 (sICAM-1) in adult disseminated
non-Hodgkin's lymphoma (D-NHL) and to correlate the
findings with overall survival.
Patients and Methods : The expression of CD44s and
ICAM-1 adhesion molecules and the level of sICAM-1
were studied in 34 cases of (D-NHL). They included : 13
cases of lymphoblastic lymphoma (LBL), 5 cases of
Burkitt's lymphoma (BL), one case of diffuse large cell
lymphoma (DLCL), 14 cases of small lymphocytic lymphoma
(SLL), one case of mantle cell lymphoma (MCL).
Ten apparently healthy individuals were taken as a control
group. CD44s expression was evaluated by direct immunofluorescence,
ICAM-1 by immunoperoxidase on cytopreps
and serum level of sICAM-1 by ELISA.
Results : ICAM-1 was positive in 6/34 cases (17.6%)
of D-NHL. ICAM-1 was expressed in 2/15 (13.3%) of
low-grade NHL and 4/19 (21%) of high-grade lymphoma
with no significant difference between the two groups
(p=0.6). CD44s was expressed in 13/34 cases (38.2%) of
D-NHL; in 4/15 (26.6%) of low grade NHL and 9/19
(47.3%) of high grade lymphoma with no significant
difference between the two groups (p=0.2). The serum
levels of sICAM-1 were elevated in all patients with DNHL
compared to healthy controls with a statistically
significant difference (p<0.001), (median 1160 ng/ml,
range from 150 to 2500 ng/ml, and 375 ng/ml, range from
270 to 620 ng/ml, respectively). The median of sICAM-
1 in patients with high-grade D-NHL was significantly
(p=0.006) lower than that of those with low-grade D-NHL
(median 890 ng/ml, range from 150 to 1540 ng/ml and
1440 ng/ml, range from 380 to 2500 ng/ml respectively). The median follow-up duration for all patients was 18
months. No statistical significant difference was achieved
(p=0.8) on comparing overall survival pattern between
D-NHL lymphoma patients with positive or negative
expression of ICAM-1 or sCD44 expression. Also, no
statistically significant difference (p=0.9) was found
between patients with sICAM (above and below 600
ng/ml) at 18 months from diagnosis.
Conclusion : There is a marked heterogeneity in cell
adhesion molecule (CAM) expression in NHL and this
may correlate with degree of differentiation of malignant
lymphocytes. However the exact significance of these
findings will require functional studies to determine the
role of these CAMs in each subtype of NHL.</abstract><cop>Cairo, Egypt</cop><pub>Cairo University, National Cancer Institute</pub><pmid>16116502</pmid><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cell adhesion molecules Lymphomas الأورام الجزيئات الحيوية |
| title | Intercellular adhesion molecule-1 (icam-1), cd44s expression, and serum level of sicam-1 in disseminated non-Hodgkin's lymphoma : correlation with overall survival |
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