Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease
Objective To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Baskent University School of Medicine in Turkey. Patient(s) Thirty-one patients with PCOS and 31 non-PCOS (control) patients. Intervention(s) D...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2009-06, Vol.91 (6), p.2545-2550 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2550 |
|---|---|
| container_issue | 6 |
| container_start_page | 2545 |
| container_title | Fertility and sterility |
| container_volume | 91 |
| creator | Oktem, Mesut, M.D Ozcimen, Emel Ebru, M.D Uckuyu, Ayla, M.D Esinler, Ibrahim, M.D Pamuk, Baris, M.D Bayraktar, Nilufer, M.D Kulaksizoglu, Sevsen, M.D Zeyneloglu, Hulusi B., M.D |
| description | Objective To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Baskent University School of Medicine in Turkey. Patient(s) Thirty-one patients with PCOS and 31 non-PCOS (control) patients. Intervention(s) Determination of plasma sCD40L and homocysteine levels. Main Outcome Measure(s) Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E2 , total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP). Result(s) The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 ± 3.65 ng/mL vs. 3.45 ± 2.64 ng/mL, respectively). Conclusion(s) Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine. |
| doi_str_mv | 10.1016/j.fertnstert.2008.03.039 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67310642</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0015028208007061</els_id><sourcerecordid>67310642</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-4e67d865091729e07a2cd24538604ab08b1596b81196d50735ad565e6a0052b33</originalsourceid><addsrcrecordid>eNqNUlGL1DAQLqJ4e6d_QfKiT3adtE3avgje6qlwoKA-hzSZavbSZs20K_33pu7igU_CkDDwfTPffHxZxjhsOXD5ar_tMU4jTendFgDNFspU7YNsw4WQuZCifJhtALjIoWiKi-ySaA8AktfF4-yCN0JUom032fw5-MUsNDnDwlHHhdEy2hgGZI6YJgrG6Qkt--WmHww9Hv90B69p0IyCnzuPbPe2Aubddz3al0yzQcc7jCz0zIQYxnWqjknrwqwj1IRPske99oRPz_9V9u3m3dfdh_z20_uPuze3uRFQT3mFsraNFNAm2S1CrQtji0qUjYRKd9B0XLSyazhvpU2MUmibTkepAUTRleVV9uI09xDDzxlpUoMjg97rEcNMStYlB1kVCdicgCYGooi9OkSXzlgUB7Varvbq3nK1Wq6gTNUm6rPzjrkb0N4Tzx4nwPMzQJPRvo96NI7-4gouueB81XB9wmFy5OgwKjIOR4PWRTSTssH9j5rX_wwx3o0u7b3DBWkf5jgmxxVXVChQX9aIrAmBBqBO8Sh_A32zubk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67310642</pqid></control><display><type>article</type><title>Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Oktem, Mesut, M.D ; Ozcimen, Emel Ebru, M.D ; Uckuyu, Ayla, M.D ; Esinler, Ibrahim, M.D ; Pamuk, Baris, M.D ; Bayraktar, Nilufer, M.D ; Kulaksizoglu, Sevsen, M.D ; Zeyneloglu, Hulusi B., M.D</creator><creatorcontrib>Oktem, Mesut, M.D ; Ozcimen, Emel Ebru, M.D ; Uckuyu, Ayla, M.D ; Esinler, Ibrahim, M.D ; Pamuk, Baris, M.D ; Bayraktar, Nilufer, M.D ; Kulaksizoglu, Sevsen, M.D ; Zeyneloglu, Hulusi B., M.D</creatorcontrib><description>Objective To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Baskent University School of Medicine in Turkey. Patient(s) Thirty-one patients with PCOS and 31 non-PCOS (control) patients. Intervention(s) Determination of plasma sCD40L and homocysteine levels. Main Outcome Measure(s) Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E2 , total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP). Result(s) The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 ± 3.65 ng/mL vs. 3.45 ± 2.64 ng/mL, respectively). Conclusion(s) Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2008.03.039</identifier><identifier>PMID: 18554599</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Amenorrhea - epidemiology ; Biological and medical sciences ; Biomarkers - blood ; C-reactive protein ; Cardiology. Vascular system ; CD40 Ligand - blood ; coronary artery disease ; Coronary Disease - blood ; Coronary Disease - complications ; Coronary heart disease ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Heart ; homocysteine ; Homocysteine - blood ; Humans ; Insulin - blood ; Internal Medicine ; Medical sciences ; Non tumoral diseases ; Obstetrics and Gynecology ; Oligomenorrhea - epidemiology ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - pathology ; Reference Values ; sCD40L ; Waist-Hip Ratio ; Young Adult</subject><ispartof>Fertility and sterility, 2009-06, Vol.91 (6), p.2545-2550</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2009 American Society for Reproductive Medicine</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-4e67d865091729e07a2cd24538604ab08b1596b81196d50735ad565e6a0052b33</citedby><cites>FETCH-LOGICAL-c507t-4e67d865091729e07a2cd24538604ab08b1596b81196d50735ad565e6a0052b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028208007061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21615112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18554599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oktem, Mesut, M.D</creatorcontrib><creatorcontrib>Ozcimen, Emel Ebru, M.D</creatorcontrib><creatorcontrib>Uckuyu, Ayla, M.D</creatorcontrib><creatorcontrib>Esinler, Ibrahim, M.D</creatorcontrib><creatorcontrib>Pamuk, Baris, M.D</creatorcontrib><creatorcontrib>Bayraktar, Nilufer, M.D</creatorcontrib><creatorcontrib>Kulaksizoglu, Sevsen, M.D</creatorcontrib><creatorcontrib>Zeyneloglu, Hulusi B., M.D</creatorcontrib><title>Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Baskent University School of Medicine in Turkey. Patient(s) Thirty-one patients with PCOS and 31 non-PCOS (control) patients. Intervention(s) Determination of plasma sCD40L and homocysteine levels. Main Outcome Measure(s) Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E2 , total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP). Result(s) The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 ± 3.65 ng/mL vs. 3.45 ± 2.64 ng/mL, respectively). Conclusion(s) Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.</description><subject>Adult</subject><subject>Amenorrhea - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-reactive protein</subject><subject>Cardiology. Vascular system</subject><subject>CD40 Ligand - blood</subject><subject>coronary artery disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - complications</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Obstetrics and Gynecology</subject><subject>Oligomenorrhea - epidemiology</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>Reference Values</subject><subject>sCD40L</subject><subject>Waist-Hip Ratio</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUlGL1DAQLqJ4e6d_QfKiT3adtE3avgje6qlwoKA-hzSZavbSZs20K_33pu7igU_CkDDwfTPffHxZxjhsOXD5ar_tMU4jTendFgDNFspU7YNsw4WQuZCifJhtALjIoWiKi-ySaA8AktfF4-yCN0JUom032fw5-MUsNDnDwlHHhdEy2hgGZI6YJgrG6Qkt--WmHww9Hv90B69p0IyCnzuPbPe2Aubddz3al0yzQcc7jCz0zIQYxnWqjknrwqwj1IRPske99oRPz_9V9u3m3dfdh_z20_uPuze3uRFQT3mFsraNFNAm2S1CrQtji0qUjYRKd9B0XLSyazhvpU2MUmibTkepAUTRleVV9uI09xDDzxlpUoMjg97rEcNMStYlB1kVCdicgCYGooi9OkSXzlgUB7Varvbq3nK1Wq6gTNUm6rPzjrkb0N4Tzx4nwPMzQJPRvo96NI7-4gouueB81XB9wmFy5OgwKjIOR4PWRTSTssH9j5rX_wwx3o0u7b3DBWkf5jgmxxVXVChQX9aIrAmBBqBO8Sh_A32zubk</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Oktem, Mesut, M.D</creator><creator>Ozcimen, Emel Ebru, M.D</creator><creator>Uckuyu, Ayla, M.D</creator><creator>Esinler, Ibrahim, M.D</creator><creator>Pamuk, Baris, M.D</creator><creator>Bayraktar, Nilufer, M.D</creator><creator>Kulaksizoglu, Sevsen, M.D</creator><creator>Zeyneloglu, Hulusi B., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease</title><author>Oktem, Mesut, M.D ; Ozcimen, Emel Ebru, M.D ; Uckuyu, Ayla, M.D ; Esinler, Ibrahim, M.D ; Pamuk, Baris, M.D ; Bayraktar, Nilufer, M.D ; Kulaksizoglu, Sevsen, M.D ; Zeyneloglu, Hulusi B., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-4e67d865091729e07a2cd24538604ab08b1596b81196d50735ad565e6a0052b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Amenorrhea - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-reactive protein</topic><topic>Cardiology. Vascular system</topic><topic>CD40 Ligand - blood</topic><topic>coronary artery disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - complications</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Obstetrics and Gynecology</topic><topic>Oligomenorrhea - epidemiology</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>Reference Values</topic><topic>sCD40L</topic><topic>Waist-Hip Ratio</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oktem, Mesut, M.D</creatorcontrib><creatorcontrib>Ozcimen, Emel Ebru, M.D</creatorcontrib><creatorcontrib>Uckuyu, Ayla, M.D</creatorcontrib><creatorcontrib>Esinler, Ibrahim, M.D</creatorcontrib><creatorcontrib>Pamuk, Baris, M.D</creatorcontrib><creatorcontrib>Bayraktar, Nilufer, M.D</creatorcontrib><creatorcontrib>Kulaksizoglu, Sevsen, M.D</creatorcontrib><creatorcontrib>Zeyneloglu, Hulusi B., M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oktem, Mesut, M.D</au><au>Ozcimen, Emel Ebru, M.D</au><au>Uckuyu, Ayla, M.D</au><au>Esinler, Ibrahim, M.D</au><au>Pamuk, Baris, M.D</au><au>Bayraktar, Nilufer, M.D</au><au>Kulaksizoglu, Sevsen, M.D</au><au>Zeyneloglu, Hulusi B., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>91</volume><issue>6</issue><spage>2545</spage><epage>2550</epage><pages>2545-2550</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). Design Prospective study. Setting Baskent University School of Medicine in Turkey. Patient(s) Thirty-one patients with PCOS and 31 non-PCOS (control) patients. Intervention(s) Determination of plasma sCD40L and homocysteine levels. Main Outcome Measure(s) Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E2 , total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP). Result(s) The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 ± 3.65 ng/mL vs. 3.45 ± 2.64 ng/mL, respectively). Conclusion(s) Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18554599</pmid><doi>10.1016/j.fertnstert.2008.03.039</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2009-06, Vol.91 (6), p.2545-2550 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67310642 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Amenorrhea - epidemiology Biological and medical sciences Biomarkers - blood C-reactive protein Cardiology. Vascular system CD40 Ligand - blood coronary artery disease Coronary Disease - blood Coronary Disease - complications Coronary heart disease Female Female genital diseases Gynecology. Andrology. Obstetrics Heart homocysteine Homocysteine - blood Humans Insulin - blood Internal Medicine Medical sciences Non tumoral diseases Obstetrics and Gynecology Oligomenorrhea - epidemiology Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - pathology Reference Values sCD40L Waist-Hip Ratio Young Adult |
| title | Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A14%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polycystic%20ovary%20syndrome%20is%20associated%20with%20elevated%20plasma%20soluble%20CD40%20ligand,%20a%20marker%20of%20coronary%20artery%20disease&rft.jtitle=Fertility%20and%20sterility&rft.au=Oktem,%20Mesut,%20M.D&rft.date=2009-06-01&rft.volume=91&rft.issue=6&rft.spage=2545&rft.epage=2550&rft.pages=2545-2550&rft.issn=0015-0282&rft.eissn=1556-5653&rft.coden=FESTAS&rft_id=info:doi/10.1016/j.fertnstert.2008.03.039&rft_dat=%3Cproquest_cross%3E67310642%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67310642&rft_id=info:pmid/18554599&rft_els_id=1_s2_0_S0015028208007061&rfr_iscdi=true |