Apolipoprotein B gene polymorphisms in people in the east Mediterranean area of Turkey
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ---> [corrected] Gln, Arg 3500 ---> [corrected] Trp and Arg 3531 ---> [corrected] Cys). We estimated...
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| Veröffentlicht in: | Eastern Mediterranean health journal 2004-01, Vol.10 (1-2), p.125-130 |
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| container_title | Eastern Mediterranean health journal |
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| creator | Tamer, L Tanriverdi, K Ercan, B Unlu, A Sucu, N Pekdemir, H Atik, U |
| description | Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ---> [corrected] Gln, Arg 3500 ---> [corrected] Trp and Arg 3531 ---> [corrected] Cys). We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ---> [corrected] Trp) and G9775A (Arg 3500 ---> [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them. |
| doi_str_mv | 10.26719/2004.10.1-2.125 |
| format | Article |
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Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ---> [corrected] Gln, Arg 3500 ---> [corrected] Trp and Arg 3531 ---> [corrected] Cys). We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ---> [corrected] Trp) and G9775A (Arg 3500 ---> [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. 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Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ---> [corrected] Gln, Arg 3500 ---> [corrected] Trp and Arg 3531 ---> [corrected] Cys). We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ---> [corrected] Trp) and G9775A (Arg 3500 ---> [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them.</description><subject>Adult</subject><subject>Apolipoprotein B-100</subject><subject>Apolipoproteins A - blood</subject><subject>Apolipoproteins B - blood</subject><subject>Apolipoproteins B - genetics</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - epidemiology</subject><subject>Arteriosclerosis - genetics</subject><subject>Case-Control Studies</subject><subject>Causality</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - epidemiology</subject><subject>Hypercholesterolemia - genetics</subject><subject>Male</subject><subject>Mediterranean Region - epidemiology</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Point Mutation - genetics</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population Surveillance</subject><subject>Rare Diseases</subject><subject>Triglycerides - blood</subject><subject>Turkey - epidemiology</subject><issn>1020-3397</issn><issn>1687-1634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtPwzAQxi0EoqWwMyFPbCnnR2xnLBUvqYilsFp5XGggqYOdDP3vcWklhtPd9-nu9OlHyDWDOVeaZXccQM6jYgmfM56ekClTRidMCXkaZ-CQCJHpCbkI4QuAGyP5OZkwxYFppqfkY9G7tuld792AzZbe00_cIo3mrnO-3zShCzT6Pbq-xf00bJBiHgb6ilUzoPf5FvMtzT3m1NV0Pfpv3F2SszpvA14d-4y8Pz6sl8_J6u3pZblYJSVPZZoUXCiuAaUxWIpKFqKIFXPyAipthIJUFrrAGkxWZzLDIlXSZFBWTDJWV2JGbg9_Y_6fEcNguyaU2LYxlBuDVVowkDyLi3BYLL0LwWNte990ud9ZBvaPpd2z3CtmuY0s48nN8fdYdFj9HxzhiV-4-25Q</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Tamer, L</creator><creator>Tanriverdi, K</creator><creator>Ercan, B</creator><creator>Unlu, A</creator><creator>Sucu, N</creator><creator>Pekdemir, H</creator><creator>Atik, U</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Apolipoprotein B gene polymorphisms in people in the east Mediterranean area of Turkey</title><author>Tamer, L ; Tanriverdi, K ; Ercan, B ; Unlu, A ; Sucu, N ; Pekdemir, H ; Atik, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2545-b236270e488ec3d4b3b4b30022b0d7836054b7bef089f949eb564890cd1411fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Apolipoprotein B-100</topic><topic>Apolipoproteins A - blood</topic><topic>Apolipoproteins B - blood</topic><topic>Apolipoproteins B - genetics</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - epidemiology</topic><topic>Arteriosclerosis - genetics</topic><topic>Case-Control Studies</topic><topic>Causality</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - epidemiology</topic><topic>Hypercholesterolemia - genetics</topic><topic>Male</topic><topic>Mediterranean Region - epidemiology</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Point Mutation - genetics</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Population Surveillance</topic><topic>Rare Diseases</topic><topic>Triglycerides - blood</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamer, L</creatorcontrib><creatorcontrib>Tanriverdi, K</creatorcontrib><creatorcontrib>Ercan, B</creatorcontrib><creatorcontrib>Unlu, A</creatorcontrib><creatorcontrib>Sucu, N</creatorcontrib><creatorcontrib>Pekdemir, H</creatorcontrib><creatorcontrib>Atik, U</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Eastern Mediterranean health journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamer, L</au><au>Tanriverdi, K</au><au>Ercan, B</au><au>Unlu, A</au><au>Sucu, N</au><au>Pekdemir, H</au><au>Atik, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein B gene polymorphisms in people in the east Mediterranean area of Turkey</atitle><jtitle>Eastern Mediterranean health journal</jtitle><addtitle>East Mediterr Health J</addtitle><date>2004-01</date><risdate>2004</risdate><volume>10</volume><issue>1-2</issue><spage>125</spage><epage>130</epage><pages>125-130</pages><issn>1020-3397</issn><eissn>1687-1634</eissn><abstract>Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ---> [corrected] Gln, Arg 3500 ---> [corrected] Trp and Arg 3531 ---> [corrected] Cys). We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ---> [corrected] Trp) and G9775A (Arg 3500 ---> [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them.</abstract><cop>Egypt</cop><pmid>16201717</pmid><doi>10.26719/2004.10.1-2.125</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Apolipoprotein B-100 Apolipoproteins A - blood Apolipoproteins B - blood Apolipoproteins B - genetics Arteriosclerosis - blood Arteriosclerosis - epidemiology Arteriosclerosis - genetics Case-Control Studies Causality Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood Female Gene Frequency - genetics Humans Hypercholesterolemia - blood Hypercholesterolemia - epidemiology Hypercholesterolemia - genetics Male Mediterranean Region - epidemiology Middle Aged Molecular Epidemiology Point Mutation - genetics Polymerase Chain Reaction - methods Polymorphism, Genetic - genetics Population Surveillance Rare Diseases Triglycerides - blood Turkey - epidemiology |
| title | Apolipoprotein B gene polymorphisms in people in the east Mediterranean area of Turkey |
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