Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy
Background The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. Methods Between July 1995 and May 2007, 148 patients with...
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| Veröffentlicht in: | International journal of colorectal disease 2009-07, Vol.24 (7), p.741-748 |
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| creator | Moreno García, V Cejas, P Blanco Codesido, M Feliu Batlle, J de Castro Carpeño, J Belda-Iniesta, C Barriuso, J Sánchez, J. J Larrauri, J González-Barón, M Casado, E |
| description | Background The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. Methods Between July 1995 and May 2007, 148 patients with primary rectal adenocarcinoma received neoadjuvant chemoradiotherapy followed by mesorectal excision. Preoperative treatment included various protocols, UFT and leucovorin (28%) and oxaliplatin-based chemotherapy (72%). Clinical and pathological variables were evaluated in relation to patient outcomes. Results Thirteen percent of patients achieved a complete pathologic response. No response or minimal response as defined by Dworak (Tumor Regression Grade 0/1) was observed in 30 patients (20%). At a median follow-up of 37 months, the 3-year DFS and OS were 64% and 83%, respectively. Pre-treatment serum carcinoembryonic antigen (CEA) level |
| doi_str_mv | 10.1007/s00384-009-0682-6 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67310025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67310025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-4dd31f34efc44516c85bf960bada49aa6de153ece835c681910ededead76e42c3</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVpaTZpf0AvrSikN7f6smwdQ-hHIJBAm7OYlca7XmxpK9lb9t9XwUsDPQQdBjHPO_MyLyHvOPvMGWu-ZMZkqyrGTMV0Kyr9gqy4kqLiQouXZMV4Yypu6vaMnOe8Y-WvG_WanHEjaqMNW5Fwn-ImxDz1jh5gmJHGjjpIrg8Rx3U6xlA6EKZ-g4EOeMCB9oEmdBMMBQwOE50SwoSe_umnLQ0Ywe_mQ9FQt8UxJvB9nLaYYH98Q151MGR8e6oX5OHb11_XP6rbu-8311e3lVNCTpXyXvJOKuycUjXXrq3XndFsDR6UAdAeeS3RYStrp1tuOENfHvhGoxJOXpBPy9x9ir9nzJMd--xwGKDYm7PVjSwXFHUBP_4H7uKcQvFmBde1kLKVBeIL5FLMOWFn96kfIR0tZ_YxCbskYUsS9jEJq4vm_WnwvB7RPylOpy_A5QmA7GDoUrlln_9xZbsWjLWFEwuXSytsMD05fG77h0XUQbSwSWXww0_BuGRcSyPbWv4F7xusVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216523383</pqid></control><display><type>article</type><title>Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Moreno García, V ; Cejas, P ; Blanco Codesido, M ; Feliu Batlle, J ; de Castro Carpeño, J ; Belda-Iniesta, C ; Barriuso, J ; Sánchez, J. J ; Larrauri, J ; González-Barón, M ; Casado, E</creator><creatorcontrib>Moreno García, V ; Cejas, P ; Blanco Codesido, M ; Feliu Batlle, J ; de Castro Carpeño, J ; Belda-Iniesta, C ; Barriuso, J ; Sánchez, J. J ; Larrauri, J ; González-Barón, M ; Casado, E</creatorcontrib><description>Background The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. Methods Between July 1995 and May 2007, 148 patients with primary rectal adenocarcinoma received neoadjuvant chemoradiotherapy followed by mesorectal excision. Preoperative treatment included various protocols, UFT and leucovorin (28%) and oxaliplatin-based chemotherapy (72%). Clinical and pathological variables were evaluated in relation to patient outcomes. Results Thirteen percent of patients achieved a complete pathologic response. No response or minimal response as defined by Dworak (Tumor Regression Grade 0/1) was observed in 30 patients (20%). At a median follow-up of 37 months, the 3-year DFS and OS were 64% and 83%, respectively. Pre-treatment serum carcinoembryonic antigen (CEA) level <= 2.5 ng/ml was associated with higher DFS (74 vs. 53%; p = 0.018), higher complete pathologic responses (21 vs. 9%; p = 0.05), and less recurrences (24 vs. 44%; p = 0.014). Conclusion The data suggest that a CEA level <= 2.5 ng/ml might be a predictor not only of tumor response, as has been suggested before, but also of DFS. This finding could be useful in the future to predict individual risk and to develop more aggressive or alternative strategies.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-009-0682-6</identifier><identifier>PMID: 19259690</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoembryonic Antigen - blood ; Disease-Free Survival ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Humans ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neoadjuvant Therapy ; Original Article ; Proctology ; Prognosis ; Rectal Neoplasms - blood ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Recurrence ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Treatment Outcome ; Tumors</subject><ispartof>International journal of colorectal disease, 2009-07, Vol.24 (7), p.741-748</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-4dd31f34efc44516c85bf960bada49aa6de153ece835c681910ededead76e42c3</citedby><cites>FETCH-LOGICAL-c423t-4dd31f34efc44516c85bf960bada49aa6de153ece835c681910ededead76e42c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-009-0682-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-009-0682-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21662008$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19259690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno García, V</creatorcontrib><creatorcontrib>Cejas, P</creatorcontrib><creatorcontrib>Blanco Codesido, M</creatorcontrib><creatorcontrib>Feliu Batlle, J</creatorcontrib><creatorcontrib>de Castro Carpeño, J</creatorcontrib><creatorcontrib>Belda-Iniesta, C</creatorcontrib><creatorcontrib>Barriuso, J</creatorcontrib><creatorcontrib>Sánchez, J. J</creatorcontrib><creatorcontrib>Larrauri, J</creatorcontrib><creatorcontrib>González-Barón, M</creatorcontrib><creatorcontrib>Casado, E</creatorcontrib><title>Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Background The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. Methods Between July 1995 and May 2007, 148 patients with primary rectal adenocarcinoma received neoadjuvant chemoradiotherapy followed by mesorectal excision. Preoperative treatment included various protocols, UFT and leucovorin (28%) and oxaliplatin-based chemotherapy (72%). Clinical and pathological variables were evaluated in relation to patient outcomes. Results Thirteen percent of patients achieved a complete pathologic response. No response or minimal response as defined by Dworak (Tumor Regression Grade 0/1) was observed in 30 patients (20%). At a median follow-up of 37 months, the 3-year DFS and OS were 64% and 83%, respectively. Pre-treatment serum carcinoembryonic antigen (CEA) level <= 2.5 ng/ml was associated with higher DFS (74 vs. 53%; p = 0.018), higher complete pathologic responses (21 vs. 9%; p = 0.05), and less recurrences (24 vs. 44%; p = 0.014). Conclusion The data suggest that a CEA level <= 2.5 ng/ml might be a predictor not only of tumor response, as has been suggested before, but also of DFS. This finding could be useful in the future to predict individual risk and to develop more aggressive or alternative strategies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoadjuvant Therapy</subject><subject>Original Article</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - blood</subject><subject>Rectal Neoplasms - diagnosis</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Recurrence</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1r3DAQhkVpaTZpf0AvrSikN7f6smwdQ-hHIJBAm7OYlca7XmxpK9lb9t9XwUsDPQQdBjHPO_MyLyHvOPvMGWu-ZMZkqyrGTMV0Kyr9gqy4kqLiQouXZMV4Yypu6vaMnOe8Y-WvG_WanHEjaqMNW5Fwn-ImxDz1jh5gmJHGjjpIrg8Rx3U6xlA6EKZ-g4EOeMCB9oEmdBMMBQwOE50SwoSe_umnLQ0Ywe_mQ9FQt8UxJvB9nLaYYH98Q151MGR8e6oX5OHb11_XP6rbu-8311e3lVNCTpXyXvJOKuycUjXXrq3XndFsDR6UAdAeeS3RYStrp1tuOENfHvhGoxJOXpBPy9x9ir9nzJMd--xwGKDYm7PVjSwXFHUBP_4H7uKcQvFmBde1kLKVBeIL5FLMOWFn96kfIR0tZ_YxCbskYUsS9jEJq4vm_WnwvB7RPylOpy_A5QmA7GDoUrlln_9xZbsWjLWFEwuXSytsMD05fG77h0XUQbSwSWXww0_BuGRcSyPbWv4F7xusVQ</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Moreno García, V</creator><creator>Cejas, P</creator><creator>Blanco Codesido, M</creator><creator>Feliu Batlle, J</creator><creator>de Castro Carpeño, J</creator><creator>Belda-Iniesta, C</creator><creator>Barriuso, J</creator><creator>Sánchez, J. J</creator><creator>Larrauri, J</creator><creator>González-Barón, M</creator><creator>Casado, E</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy</title><author>Moreno García, V ; Cejas, P ; Blanco Codesido, M ; Feliu Batlle, J ; de Castro Carpeño, J ; Belda-Iniesta, C ; Barriuso, J ; Sánchez, J. 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Abdomen</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoadjuvant Therapy</topic><topic>Original Article</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - blood</topic><topic>Rectal Neoplasms - diagnosis</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Recurrence</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno García, V</creatorcontrib><creatorcontrib>Cejas, P</creatorcontrib><creatorcontrib>Blanco Codesido, M</creatorcontrib><creatorcontrib>Feliu Batlle, J</creatorcontrib><creatorcontrib>de Castro Carpeño, J</creatorcontrib><creatorcontrib>Belda-Iniesta, C</creatorcontrib><creatorcontrib>Barriuso, J</creatorcontrib><creatorcontrib>Sánchez, J. J</creatorcontrib><creatorcontrib>Larrauri, J</creatorcontrib><creatorcontrib>González-Barón, M</creatorcontrib><creatorcontrib>Casado, E</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno García, V</au><au>Cejas, P</au><au>Blanco Codesido, M</au><au>Feliu Batlle, J</au><au>de Castro Carpeño, J</au><au>Belda-Iniesta, C</au><au>Barriuso, J</au><au>Sánchez, J. J</au><au>Larrauri, J</au><au>González-Barón, M</au><au>Casado, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>24</volume><issue>7</issue><spage>741</spage><epage>748</epage><pages>741-748</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Background The purpose of this study was to identify clinical and pathological parameters to improve prediction of disease-free survival (DFS) and overall survival (OS) in patients treated with neoadjuvant chemoradiotherapy for rectal cancer. Methods Between July 1995 and May 2007, 148 patients with primary rectal adenocarcinoma received neoadjuvant chemoradiotherapy followed by mesorectal excision. Preoperative treatment included various protocols, UFT and leucovorin (28%) and oxaliplatin-based chemotherapy (72%). Clinical and pathological variables were evaluated in relation to patient outcomes. Results Thirteen percent of patients achieved a complete pathologic response. No response or minimal response as defined by Dworak (Tumor Regression Grade 0/1) was observed in 30 patients (20%). At a median follow-up of 37 months, the 3-year DFS and OS were 64% and 83%, respectively. Pre-treatment serum carcinoembryonic antigen (CEA) level <= 2.5 ng/ml was associated with higher DFS (74 vs. 53%; p = 0.018), higher complete pathologic responses (21 vs. 9%; p = 0.05), and less recurrences (24 vs. 44%; p = 0.014). Conclusion The data suggest that a CEA level <= 2.5 ng/ml might be a predictor not only of tumor response, as has been suggested before, but also of DFS. This finding could be useful in the future to predict individual risk and to develop more aggressive or alternative strategies.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19259690</pmid><doi>10.1007/s00384-009-0682-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoembryonic Antigen - blood Disease-Free Survival Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoadjuvant Therapy Original Article Proctology Prognosis Rectal Neoplasms - blood Rectal Neoplasms - diagnosis Rectal Neoplasms - pathology Rectal Neoplasms - therapy Recurrence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Treatment Outcome Tumors |
| title | Prognostic value of carcinoembryonic antigen level in rectal cancer treated with neoadjuvant chemoradiotherapy |
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