Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed
Introduction: Moderate and regular consumption of wine reduces the risk of acute coronary thrombotic events. The mechanism of the anti-thrombotic effect of wine is not clear. Extract or purified ingredients of grapes have not yet been studied for anti-thrombotic effect. Materials and methods: Anti-t...
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| Veröffentlicht in: | Thrombosis research 2005, Vol.115 (1), p.115-121 |
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| container_title | Thrombosis research |
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| creator | Sano, Takashi Oda, Etsuko Yamashita, Tsutomu Naemura, Aki Ijiri, Yoshinobu Yamakoshi, Jun Yamamoto, Junichiro |
| description | Introduction: Moderate and regular consumption of wine reduces the risk of acute coronary thrombotic events. The mechanism of the anti-thrombotic effect of wine is not clear. Extract or purified ingredients of grapes have not yet been studied for anti-thrombotic effect.
Materials and methods: Anti-thrombotic effect of proanthocyanidin, a highly purified ingredient of grape seed, was assessed by a shear-induced thrombosis test in vitro and by a laser-induced thrombosis test in the mouse carotid artery, in vivo.
Results and conclusions: Intravenously (20 mg/kg body weight, BW) or orally (2×200 mg/kg BW) administered proanthocyanidin significantly inhibited the laser-irradiation induced thrombus formation in the carotid artery (both
P=0.01). Subsequent to oral administration of proanthocyanidin, in vitro platelet reactivity to shear stress has been inhibited. The latter suggests that the in vivo anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets. |
| doi_str_mv | 10.1016/j.thromres.2004.07.015 |
| format | Article |
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Materials and methods: Anti-thrombotic effect of proanthocyanidin, a highly purified ingredient of grape seed, was assessed by a shear-induced thrombosis test in vitro and by a laser-induced thrombosis test in the mouse carotid artery, in vivo.
Results and conclusions: Intravenously (20 mg/kg body weight, BW) or orally (2×200 mg/kg BW) administered proanthocyanidin significantly inhibited the laser-irradiation induced thrombus formation in the carotid artery (both
P=0.01). Subsequent to oral administration of proanthocyanidin, in vitro platelet reactivity to shear stress has been inhibited. The latter suggests that the in vivo anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2004.07.015</identifier><identifier>PMID: 15567462</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Coagulation Tests ; Bones, joints and connective tissue. Antiinflammatory agents ; C57BL/6 mice ; Cardiology. Vascular system ; Cardiovascular system ; Carotid Arteries ; Disease Models, Animal ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Fibrinolytic Agents - administration & dosage ; Fibrinolytic Agents - pharmacology ; Laser-induced thrombosis ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Platelet Activation - drug effects ; Platelet Aggregation Inhibitors ; Platelet function ; Platelet Function Tests ; Platelet reactivity ; Proanthocyanidin ; Proanthocyanidins - administration & dosage ; Proanthocyanidins - pharmacology ; Seeds ; Shear-stress ; Stress, Mechanical ; Thrombosis - drug therapy ; Thrombosis - prevention & control ; Vasodilator agents. Cerebral vasodilators ; Vitis - chemistry ; Wine</subject><ispartof>Thrombosis research, 2005, Vol.115 (1), p.115-121</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-1fad8fbe813db4742098d12356fbb548eca0ffbd61c252785ca817b81591ea853</citedby><cites>FETCH-LOGICAL-c460t-1fad8fbe813db4742098d12356fbb548eca0ffbd61c252785ca817b81591ea853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384804004177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16476734$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15567462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sano, Takashi</creatorcontrib><creatorcontrib>Oda, Etsuko</creatorcontrib><creatorcontrib>Yamashita, Tsutomu</creatorcontrib><creatorcontrib>Naemura, Aki</creatorcontrib><creatorcontrib>Ijiri, Yoshinobu</creatorcontrib><creatorcontrib>Yamakoshi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Junichiro</creatorcontrib><title>Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Introduction: Moderate and regular consumption of wine reduces the risk of acute coronary thrombotic events. The mechanism of the anti-thrombotic effect of wine is not clear. Extract or purified ingredients of grapes have not yet been studied for anti-thrombotic effect.
Materials and methods: Anti-thrombotic effect of proanthocyanidin, a highly purified ingredient of grape seed, was assessed by a shear-induced thrombosis test in vitro and by a laser-induced thrombosis test in the mouse carotid artery, in vivo.
Results and conclusions: Intravenously (20 mg/kg body weight, BW) or orally (2×200 mg/kg BW) administered proanthocyanidin significantly inhibited the laser-irradiation induced thrombus formation in the carotid artery (both
P=0.01). Subsequent to oral administration of proanthocyanidin, in vitro platelet reactivity to shear stress has been inhibited. The latter suggests that the in vivo anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Coagulation Tests</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>C57BL/6 mice</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Carotid Arteries</subject><subject>Disease Models, Animal</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Laser-induced thrombosis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Activation - drug effects</subject><subject>Platelet Aggregation Inhibitors</subject><subject>Platelet function</subject><subject>Platelet Function Tests</subject><subject>Platelet reactivity</subject><subject>Proanthocyanidin</subject><subject>Proanthocyanidins - administration & dosage</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Seeds</subject><subject>Shear-stress</subject><subject>Stress, Mechanical</subject><subject>Thrombosis - drug therapy</subject><subject>Thrombosis - prevention & control</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><subject>Vitis - chemistry</subject><subject>Wine</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EouXxC1U2sCLBTvzKDoR4SZW6gbXl2GNwlSbFTpD69xgaxJLVLObcmauD0ILggmDCr9fF8B76TYBYlBjTAosCE3aA5kSKOi-pKA_RPC3qvJJUztBJjGuMiSA1O0YzwhgXlJdztLrtBp__3Gr6wZsMnAMzZL3LtqHX3fDem53uvPXdVaaz7Ri882Az370FsB66H_Qt6C1kEcCeoSOn2wjn0zxFrw_3L3dP-XL1-Hx3u8wN5XjIidNWugYkqWxDBS1xLS0pK8Zd0zAqwWjsXGM5MSUrhWRGSyIaSVhNQEtWnaLL_d3U8mOEOKiNjwbaVnfQj1FxUeFa1HUC-R40oY8xgFPb4Dc67BTB6lulWqtflepbpcJCJZUpuJg-jM0G7F9scpeAiwnQ0ejWBd0ZH_84TkVqQRN3s-cg-fj0EFQ0SZxJ-kJSrWzv_-vyBY_8lmY</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Sano, Takashi</creator><creator>Oda, Etsuko</creator><creator>Yamashita, Tsutomu</creator><creator>Naemura, Aki</creator><creator>Ijiri, Yoshinobu</creator><creator>Yamakoshi, Jun</creator><creator>Yamamoto, Junichiro</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed</title><author>Sano, Takashi ; Oda, Etsuko ; Yamashita, Tsutomu ; Naemura, Aki ; Ijiri, Yoshinobu ; Yamakoshi, Jun ; Yamamoto, Junichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-1fad8fbe813db4742098d12356fbb548eca0ffbd61c252785ca817b81591ea853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Coagulation Tests</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>C57BL/6 mice</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Carotid Arteries</topic><topic>Disease Models, Animal</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Fibrinolytic Agents - administration & dosage</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Laser-induced thrombosis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Activation - drug effects</topic><topic>Platelet Aggregation Inhibitors</topic><topic>Platelet function</topic><topic>Platelet Function Tests</topic><topic>Platelet reactivity</topic><topic>Proanthocyanidin</topic><topic>Proanthocyanidins - administration & dosage</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Seeds</topic><topic>Shear-stress</topic><topic>Stress, Mechanical</topic><topic>Thrombosis - drug therapy</topic><topic>Thrombosis - prevention & control</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><topic>Vitis - chemistry</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sano, Takashi</creatorcontrib><creatorcontrib>Oda, Etsuko</creatorcontrib><creatorcontrib>Yamashita, Tsutomu</creatorcontrib><creatorcontrib>Naemura, Aki</creatorcontrib><creatorcontrib>Ijiri, Yoshinobu</creatorcontrib><creatorcontrib>Yamakoshi, Jun</creatorcontrib><creatorcontrib>Yamamoto, Junichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sano, Takashi</au><au>Oda, Etsuko</au><au>Yamashita, Tsutomu</au><au>Naemura, Aki</au><au>Ijiri, Yoshinobu</au><au>Yamakoshi, Jun</au><au>Yamamoto, Junichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2005</date><risdate>2005</risdate><volume>115</volume><issue>1</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Introduction: Moderate and regular consumption of wine reduces the risk of acute coronary thrombotic events. The mechanism of the anti-thrombotic effect of wine is not clear. Extract or purified ingredients of grapes have not yet been studied for anti-thrombotic effect.
Materials and methods: Anti-thrombotic effect of proanthocyanidin, a highly purified ingredient of grape seed, was assessed by a shear-induced thrombosis test in vitro and by a laser-induced thrombosis test in the mouse carotid artery, in vivo.
Results and conclusions: Intravenously (20 mg/kg body weight, BW) or orally (2×200 mg/kg BW) administered proanthocyanidin significantly inhibited the laser-irradiation induced thrombus formation in the carotid artery (both
P=0.01). Subsequent to oral administration of proanthocyanidin, in vitro platelet reactivity to shear stress has been inhibited. The latter suggests that the in vivo anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>15567462</pmid><doi>10.1016/j.thromres.2004.07.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood and lymphatic vessels Blood Coagulation Tests Bones, joints and connective tissue. Antiinflammatory agents C57BL/6 mice Cardiology. Vascular system Cardiovascular system Carotid Arteries Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - pharmacology Laser-induced thrombosis Medical sciences Mice Pharmacology. Drug treatments Platelet Activation - drug effects Platelet Aggregation Inhibitors Platelet function Platelet Function Tests Platelet reactivity Proanthocyanidin Proanthocyanidins - administration & dosage Proanthocyanidins - pharmacology Seeds Shear-stress Stress, Mechanical Thrombosis - drug therapy Thrombosis - prevention & control Vasodilator agents. Cerebral vasodilators Vitis - chemistry Wine |
| title | Anti-thrombotic effect of proanthocyanidin, a purified ingredient of grape seed |
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