Phase Transitions in Frozen Systems and During Freeze-Drying: Quantification Using Synchrotron X-Ray Diffractometry

Purpose (1) To develop a synchrotron X-ray diffraction (SXRD) method to monitor phase transitions during the entire freeze-drying cycle. Aqueous sodium phosphate buffered glycine solutions with initial glycine to buffer molar ratios of 1:3 (17:50 mM), 1:1 (50 mM) and 3:1 were utilized as model syste...

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