Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice

Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated colonic hypersensitivity in mice. Despite similarly elevated Ser-P levels in feces, patients with IBD exhibit visceral hypo- or normosensitiv...

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Veröffentlicht in:	Pain (Amsterdam) 2009-07, Vol.144 (1-2), p.209-217
Hauptverfasser:	Annaházi, Anita, Gecse, Krisztina, Dabek, Marta, Ait-Belgnaoui, Afifa, Rosztóczy, András, Róka, Richárd, Molnár, Tamás, Theodorou, Vassilia, Wittmann, Tibor, Bueno, Lionel, Eutamene, Helene
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics Analysis of Variance Animals Biological and medical sciences Cathepsin G Colitis, Ulcerative - metabolism Colitis, Ulcerative - physiopathology Enzyme Inhibitors - pharmacology Feces - chemistry Female Fundamental and applied biological sciences. Psychology Humans Illness and personality Illness, stress and coping Irritable bowel syndrome Irritable Bowel Syndrome - metabolism Irritable Bowel Syndrome - physiopathology Male Medical sciences Mice Mice, Inbred C57BL Middle Aged Neuropharmacology Perception - drug effects Pharmacology. Drug treatments Proteinase-activated receptor Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Proteinase-Activated - metabolism Sensory Thresholds - drug effects Serine Endopeptidases - pharmacology Ulcerative colitis Viscera - drug effects Viscera - innervation Visceral pain
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