Comparison of Sulfadoxine‐Pyrimethamine, Unsupervised Artemether‐Lumefantrine, and Unsupervised Artesunate‐Amodiaquine Fixed‐Dose Formulation for Uncomplicated Plasmodium falciparum Malaria in Benin: A Randomized Effectiveness Noninferiority Trial

Background. We compared sulfadoxine‐pyrimethamine (SP) with unsupervised artemether‐lumefantrine (AL) and unsupervised amodiaquine‐artesunate (ASAQ) fixed‐dose formulation for the treatment of uncomplicated malaria in children in Benin. Methods. This open‐label, noninferiority comparative trial incl...

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Veröffentlicht in:	The Journal of infectious diseases 2009-07, Vol.200 (1), p.57-65
Hauptverfasser:	Faucher, Jean‐François , Aubouy, Agnès , Adeothy, Adicat , Cottrell, Gilles , Doritchamou, Justin , Gourmel, Bernard , Houzé, Pascal , Kossou, Hortense , Amedome, Hyacinthe , Massougbodji, Achille , Cot, Michel , Deloron, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Amodiaquine - therapeutic use Animals Antimalarials Antimalarials - therapeutic use Artemisinins - therapeutic use Benin Biological and medical sciences Blood Child, Preschool Dosage Drug Combinations Drug Therapy, Combination Ethanolamines - therapeutic use Experimentation Falciparum malaria Female Fluorenes - therapeutic use Fundamental and applied biological sciences. Psychology Human protozoal diseases Humans Infant Infectious diseases Life cycle. Host-agent relationship. Pathogenesis Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - prevention & control Malaria, Falciparum - transmission Male Medical sciences Medical treatment failures Microbiology Parasites Parasitic diseases Plasmodium falciparum Polymerase Chain Reaction Protozoa Protozoal diseases Pyrimethamine - therapeutic use Sulfadoxine - therapeutic use Writing tablets
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