Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss
Background Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate...
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| Veröffentlicht in: | Obesity surgery 2009-05, Vol.19 (5), p.571-576 |
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| creator | Solá, Eva Jover, Ana López-Ruiz, Antonio Jarabo, María Vayá, Amparo Morillas, Carlos Gómez-Balaguer, Marcelino Hernández-Mijares, Antonio |
| description | Background
Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate weight loss upon their levels.
Methods
Sixty-seven severe or morbid obese patients were compared with 67 controls. Patients were submitted to a 4-week very low calorie diet followed by a low calorie diet for 2 months. Exclusion criteria were organic disease, ischemic heart disease or stroke, diabetes mellitus, hyperlipidemia, and hypertension. An evaluation was performed before and after the diet, in which fibrinogen, blood count, high-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), and tumoral necrosis factor α (TNF-α) were measured. The Student
t
test was employed to compare differences between the groups and Pearson correlation coefficients were calculated.
Results
Obese patients showed higher levels of CRP (
P
|
| doi_str_mv | 10.1007/s11695-008-9772-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67307704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67307704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-f057e1464def6336776b2a81b7414b30303d69ed31f759047022d293fd78f0623</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVJ6W7S_oBeismh5OJmNJL1kVsISRrYkBxSehSyPdp6u7Y3kveQf18tuxAoJOggCT3zjoaHsa8cfnAAfZ44V7YqAUxptcbSfGBzrvMNJJojNgeroDQWxYwdp7QCQK4QP7EZt1CBNdWcPT366HuaKKZiDMXdENa-7_3UjUPRDcX9GOuuLR5qSt30clEsfPN3x12HQM20O92PLUU_UfGbuuWfqViMKX1mH4NfJ_py2E_Yr5vrp6uf5eLh9u7qclE2EnAqA1SauFSypaCEUFqrGr3htZZc1gLyapWlVvCgKwtSA2KLVoRWmwAKxQn7vs_dxPF5S2lyfZcaWq_9QOM2OaUFaA0yg2fvgtyIjEqlIKOn_6GrcRuHPIZDFIhV_nCG-B5qYh43UnCb2PU-vjgObqfG7dW4rMbt1DiTa74dgrd1T-1rxcFFBnAPpPw0LCm-dn479R-X-pXX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223225146</pqid></control><display><type>article</type><title>Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Solá, Eva ; Jover, Ana ; López-Ruiz, Antonio ; Jarabo, María ; Vayá, Amparo ; Morillas, Carlos ; Gómez-Balaguer, Marcelino ; Hernández-Mijares, Antonio</creator><creatorcontrib>Solá, Eva ; Jover, Ana ; López-Ruiz, Antonio ; Jarabo, María ; Vayá, Amparo ; Morillas, Carlos ; Gómez-Balaguer, Marcelino ; Hernández-Mijares, Antonio</creatorcontrib><description>Background
Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate weight loss upon their levels.
Methods
Sixty-seven severe or morbid obese patients were compared with 67 controls. Patients were submitted to a 4-week very low calorie diet followed by a low calorie diet for 2 months. Exclusion criteria were organic disease, ischemic heart disease or stroke, diabetes mellitus, hyperlipidemia, and hypertension. An evaluation was performed before and after the diet, in which fibrinogen, blood count, high-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), and tumoral necrosis factor α (TNF-α) were measured. The Student
t
test was employed to compare differences between the groups and Pearson correlation coefficients were calculated.
Results
Obese patients showed higher levels of CRP (
P
< 0.001), IL-6 (
P
< 0.001), TNF-α (
P
< 0.001), leukocyte (
P
= 0.001), and neutrophil count (
P
< 0.001) than controls. In obese patients, inflammatory parameters were significantly correlated with anthropometric parameters and did not differ between obese subjects with or without metabolic syndrome. Moderate weight loss (excess weight loss 19.6%) was achieved through dieting, but no change was observed in any inflammatory parameter.
Conclusions
Obesity is associated to a chronic inflammatory state that seems to be due to an increased secretion of cytokines, and this state is not related to the presence of metabolic syndrome. Moderate weight loss does not ameliorate this inflammatory state in the short term.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-008-9772-8</identifier><identifier>PMID: 19050985</identifier><language>eng</language><publisher>New York: Springer New York</publisher><subject>Acute-Phase Proteins - metabolism ; Adolescent ; Adult ; Biomarkers - blood ; Caloric Restriction ; Case-Control Studies ; Cohort Studies ; Cytokines ; Diet ; Female ; Humans ; Inflammation - blood ; Interleukin-6 - blood ; Leukocyte Count ; Male ; Medicine ; Medicine & Public Health ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - epidemiology ; Middle Aged ; Morbidity ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - diet therapy ; Obesity, Morbid - pathology ; Research Article ; Surgery ; Tumor Necrosis Factor-alpha - blood ; Weight control ; Weight Loss - physiology ; Young Adult</subject><ispartof>Obesity surgery, 2009-05, Vol.19 (5), p.571-576</ispartof><rights>Springer Science + Business Media, LLC 2008</rights><rights>Springer Science + Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f057e1464def6336776b2a81b7414b30303d69ed31f759047022d293fd78f0623</citedby><cites>FETCH-LOGICAL-c402t-f057e1464def6336776b2a81b7414b30303d69ed31f759047022d293fd78f0623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-008-9772-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-008-9772-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19050985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solá, Eva</creatorcontrib><creatorcontrib>Jover, Ana</creatorcontrib><creatorcontrib>López-Ruiz, Antonio</creatorcontrib><creatorcontrib>Jarabo, María</creatorcontrib><creatorcontrib>Vayá, Amparo</creatorcontrib><creatorcontrib>Morillas, Carlos</creatorcontrib><creatorcontrib>Gómez-Balaguer, Marcelino</creatorcontrib><creatorcontrib>Hernández-Mijares, Antonio</creatorcontrib><title>Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate weight loss upon their levels.
Methods
Sixty-seven severe or morbid obese patients were compared with 67 controls. Patients were submitted to a 4-week very low calorie diet followed by a low calorie diet for 2 months. Exclusion criteria were organic disease, ischemic heart disease or stroke, diabetes mellitus, hyperlipidemia, and hypertension. An evaluation was performed before and after the diet, in which fibrinogen, blood count, high-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), and tumoral necrosis factor α (TNF-α) were measured. The Student
t
test was employed to compare differences between the groups and Pearson correlation coefficients were calculated.
Results
Obese patients showed higher levels of CRP (
P
< 0.001), IL-6 (
P
< 0.001), TNF-α (
P
< 0.001), leukocyte (
P
= 0.001), and neutrophil count (
P
< 0.001) than controls. In obese patients, inflammatory parameters were significantly correlated with anthropometric parameters and did not differ between obese subjects with or without metabolic syndrome. Moderate weight loss (excess weight loss 19.6%) was achieved through dieting, but no change was observed in any inflammatory parameter.
Conclusions
Obesity is associated to a chronic inflammatory state that seems to be due to an increased secretion of cytokines, and this state is not related to the presence of metabolic syndrome. Moderate weight loss does not ameliorate this inflammatory state in the short term.</description><subject>Acute-Phase Proteins - metabolism</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Caloric Restriction</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Interleukin-6 - blood</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - diet therapy</subject><subject>Obesity, Morbid - pathology</subject><subject>Research Article</subject><subject>Surgery</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>Young Adult</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1r3DAQhkVJ6W7S_oBeismh5OJmNJL1kVsISRrYkBxSehSyPdp6u7Y3kveQf18tuxAoJOggCT3zjoaHsa8cfnAAfZ44V7YqAUxptcbSfGBzrvMNJJojNgeroDQWxYwdp7QCQK4QP7EZt1CBNdWcPT366HuaKKZiDMXdENa-7_3UjUPRDcX9GOuuLR5qSt30clEsfPN3x12HQM20O92PLUU_UfGbuuWfqViMKX1mH4NfJ_py2E_Yr5vrp6uf5eLh9u7qclE2EnAqA1SauFSypaCEUFqrGr3htZZc1gLyapWlVvCgKwtSA2KLVoRWmwAKxQn7vs_dxPF5S2lyfZcaWq_9QOM2OaUFaA0yg2fvgtyIjEqlIKOn_6GrcRuHPIZDFIhV_nCG-B5qYh43UnCb2PU-vjgObqfG7dW4rMbt1DiTa74dgrd1T-1rxcFFBnAPpPw0LCm-dn479R-X-pXX</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Solá, Eva</creator><creator>Jover, Ana</creator><creator>López-Ruiz, Antonio</creator><creator>Jarabo, María</creator><creator>Vayá, Amparo</creator><creator>Morillas, Carlos</creator><creator>Gómez-Balaguer, Marcelino</creator><creator>Hernández-Mijares, Antonio</creator><general>Springer New York</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss</title><author>Solá, Eva ; Jover, Ana ; López-Ruiz, Antonio ; Jarabo, María ; Vayá, Amparo ; Morillas, Carlos ; Gómez-Balaguer, Marcelino ; Hernández-Mijares, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f057e1464def6336776b2a81b7414b30303d69ed31f759047022d293fd78f0623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute-Phase Proteins - metabolism</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Caloric Restriction</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Interleukin-6 - blood</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - diet therapy</topic><topic>Obesity, Morbid - pathology</topic><topic>Research Article</topic><topic>Surgery</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solá, Eva</creatorcontrib><creatorcontrib>Jover, Ana</creatorcontrib><creatorcontrib>López-Ruiz, Antonio</creatorcontrib><creatorcontrib>Jarabo, María</creatorcontrib><creatorcontrib>Vayá, Amparo</creatorcontrib><creatorcontrib>Morillas, Carlos</creatorcontrib><creatorcontrib>Gómez-Balaguer, Marcelino</creatorcontrib><creatorcontrib>Hernández-Mijares, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solá, Eva</au><au>Jover, Ana</au><au>López-Ruiz, Antonio</au><au>Jarabo, María</au><au>Vayá, Amparo</au><au>Morillas, Carlos</au><au>Gómez-Balaguer, Marcelino</au><au>Hernández-Mijares, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>19</volume><issue>5</issue><spage>571</spage><epage>576</epage><pages>571-576</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate weight loss upon their levels.
Methods
Sixty-seven severe or morbid obese patients were compared with 67 controls. Patients were submitted to a 4-week very low calorie diet followed by a low calorie diet for 2 months. Exclusion criteria were organic disease, ischemic heart disease or stroke, diabetes mellitus, hyperlipidemia, and hypertension. An evaluation was performed before and after the diet, in which fibrinogen, blood count, high-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), and tumoral necrosis factor α (TNF-α) were measured. The Student
t
test was employed to compare differences between the groups and Pearson correlation coefficients were calculated.
Results
Obese patients showed higher levels of CRP (
P
< 0.001), IL-6 (
P
< 0.001), TNF-α (
P
< 0.001), leukocyte (
P
= 0.001), and neutrophil count (
P
< 0.001) than controls. In obese patients, inflammatory parameters were significantly correlated with anthropometric parameters and did not differ between obese subjects with or without metabolic syndrome. Moderate weight loss (excess weight loss 19.6%) was achieved through dieting, but no change was observed in any inflammatory parameter.
Conclusions
Obesity is associated to a chronic inflammatory state that seems to be due to an increased secretion of cytokines, and this state is not related to the presence of metabolic syndrome. Moderate weight loss does not ameliorate this inflammatory state in the short term.</abstract><cop>New York</cop><pub>Springer New York</pub><pmid>19050985</pmid><doi>10.1007/s11695-008-9772-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2009-05, Vol.19 (5), p.571-576 |
| issn | 0960-8923 1708-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67307704 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Acute-Phase Proteins - metabolism Adolescent Adult Biomarkers - blood Caloric Restriction Case-Control Studies Cohort Studies Cytokines Diet Female Humans Inflammation - blood Interleukin-6 - blood Leukocyte Count Male Medicine Medicine & Public Health Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Middle Aged Morbidity Obesity Obesity, Morbid - blood Obesity, Morbid - diet therapy Obesity, Morbid - pathology Research Article Surgery Tumor Necrosis Factor-alpha - blood Weight control Weight Loss - physiology Young Adult |
| title | Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss |
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