Screening and synthesis: high throughput technologies applied to parasitology
High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS u...
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| Veröffentlicht in: | Parasitology 2004-10, Vol.128 (S1), p.S71-S79 |
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| container_title | Parasitology |
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| creator | MORGAN, R. E. WESTWOOD, N. J. |
| description | High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compound collections are provided. The important issue of identifying the protein target(s) of bioactive compounds is discussed from the synthetic chemist's perspective. This article concludes by reviewing recent examples of successful target identification studies in parasitology. |
| doi_str_mv | 10.1017/S0031182004007073 |
| format | Article |
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| fulltext | fulltext |
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| issn | 0031-1820 1469-8161 |
| language | eng |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | affinity chromatography Animals automated synthesis chemical genetics Combinatorial Chemistry Techniques - methods compound collection High throughput screening Parasitology - methods phenotypic assay Proteomics - methods protozoan Protozoan Proteins - analysis review target identification technology |
| title | Screening and synthesis: high throughput technologies applied to parasitology |
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