HDAC expression and clinical prognosis in human malignancies

Abstract Histone deacetylases are known to play a central role in the regulation of several cellular properties intimately interlinked with the development and progression of cancer. Consequently, a multitude of histone deacetylase (HDAC) inhibitors have been developed and are currently tested as an...

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Veröffentlicht in:	Cancer letters 2009-08, Vol.280 (2), p.168-176
1. Verfasser:	Weichert, Wilko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Biomarkers, Tumor - biosynthesis Breast cancer Chromatin Clinical trials Expression Gastric cancer HDAC Hematology Hematology, Oncology and Palliative Medicine Histone deacetylase Histone Deacetylases - biosynthesis Humans Isoenzymes - metabolism Medical prognosis Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - enzymology Organ Specificity Prognosis Protein expression Proteins Rodents Smooth muscle Survival analysis Tumors
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