Thrombotic thrombocytopenic purpura complicating Sjögren's syndrome with crescentic glomerulonephritis and membranous nephritis

Abstract The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of Sjögren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulat...

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Veröffentlicht in:Modern rheumatology 2004-06, Vol.14 (2), p.174-178
Hauptverfasser: Abe, Haruo, Tsuboi, Norioki, Yukawa, Sonosuke, Tsuji, Souichirou, Hayashi, Haeru, Yukawa, Naoichiro, Takanashi, Hirofumi, Tahara, Koichiro, Tonozuka, Norihiko, Hayashi, Tohru
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container_end_page 178
container_issue 2
container_start_page 174
container_title Modern rheumatology
container_volume 14
creator Abe, Haruo
Tsuboi, Norioki
Yukawa, Sonosuke
Tsuji, Souichirou
Hayashi, Haeru
Yukawa, Naoichiro
Takanashi, Hirofumi
Tahara, Koichiro
Tonozuka, Norihiko
Hayashi, Tohru
description Abstract The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of Sjögren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and immune complex deposits were shown along the capillary walls of renal biopsy specimens. Despite steroid pulse therapy and plasma exchange therapy, the patient died. The etiology of TTP is unclear. This case is important when considering the etiology of TTP related to autoimmune disease.
doi_str_mv 10.3109/s10165-004-0287-4
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source Oxford University Press Journals All Titles (1996-Current)
title Thrombotic thrombocytopenic purpura complicating Sjögren's syndrome with crescentic glomerulonephritis and membranous nephritis
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