The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study: Evaluation Using Ultrasmall Superparamagnetic Iron Oxide-Enhanced Magnetic Resonance Imaging in Carotid Disease

The aim of this study was to evaluate the effects of low-dose (10 mg) and high-dose (80 mg) atorvastatin on carotid plaque inflammation as determined by ultrasmall superparamagnetic iron oxide (USPIO)-enhanced carotid magnetic resonance imaging (MRI). The hypothesis was that treatment with 80 mg ato...

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Veröffentlicht in:	Journal of the American College of Cardiology 2009-06, Vol.53 (22), p.2039-2050
Hauptverfasser:	TANG, Tjun Y, HOWARTH, Simon P. S, WARBURTON, Elizabeth A, HAYES, Paul D, VARTY, Kevin, BOYLE, Jonathan R, GAUNT, Michael E, ZALEWSKI, Andrew, GILLARD, Jonathan H, MILLER, Sam R, GRAVES, Martin J, PATTERSON, Andrew J, U-KING-IM, Jean-Marie, LI, Zhi Y, WALSH, Stewart R, BROWN, Andrew P, KIRKPATRICK, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - therapeutic use Atorvastatin Calcium Biological and medical sciences Biomarkers Cardiology Cardiology. Vascular system Carotid Arteries - drug effects Carotid Arteries - pathology Carotid Stenosis - diagnosis Carotid Stenosis - drug therapy Carotid Stenosis - pathology Cholesterol Confidence intervals Contrast Media Dextrans Double-Blind Method Female Ferrosoferric Oxide Heptanoic Acids - administration & dosage Heptanoic Acids - therapeutic use Humans Inflammation - diagnosis Inflammation - drug therapy Inflammation - pathology Iron Lipids Lipoproteins Macrophages - drug effects Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Magnetite Nanoparticles Male Medical imaging Medical sciences Middle Aged Mortality Nanoparticles NMR Nuclear magnetic resonance Oxides Plasma Proteins Pyrroles - administration & dosage Pyrroles - therapeutic use Statins Studies Tomography Triglycerides
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