Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry

Abstract Objectives To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. Methods The REACH Registry recruited >...

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Veröffentlicht in:Atherosclerosis 2009-06, Vol.204 (2), p.e86-e92
Hauptverfasser: Cacoub, Patrice P, Abola, Maria Teresa B, Baumgartner, Iris, Bhatt, Deepak L, Creager, Mark A, Liau, Chiau-Suong, Goto, Shinya, Röther, Joachim, Steg, P. Gabriel, Hirsch, Alan T
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container_end_page e92
container_issue 2
container_start_page e86
container_title Atherosclerosis
container_volume 204
creator Cacoub, Patrice P
Abola, Maria Teresa B
Baumgartner, Iris
Bhatt, Deepak L
Creager, Mark A
Liau, Chiau-Suong
Goto, Shinya
Röther, Joachim
Steg, P. Gabriel
Hirsch, Alan T
description Abstract Objectives To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. Methods The REACH Registry recruited >68000 outpatients aged ≥45 years with established atherothrombotic disease or ≥3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. Results RF control was less frequent in patients with PAD ( n = 8322), compared with those with CAD or CVD (but no PAD, n = 47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P < 0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR = 1.9); residence in North America (OR = 3.5), Japan (OR = 2.5) or Latin America (OR = 1.5); previous coronary revascularization (OR = 1.3); and statin use (OR = 1.4); whereas prior leg amputation was a negative predictor (OR = 0.7) ( P < 0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events. Conclusions Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.
doi_str_mv 10.1016/j.atherosclerosis.2008.10.023
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Gabriel ; Hirsch, Alan T</creator><creatorcontrib>Cacoub, Patrice P ; Abola, Maria Teresa B ; Baumgartner, Iris ; Bhatt, Deepak L ; Creager, Mark A ; Liau, Chiau-Suong ; Goto, Shinya ; Röther, Joachim ; Steg, P. Gabriel ; Hirsch, Alan T ; on behalf of the REACH Registry Investigators ; REACH Registry Investigators</creatorcontrib><description>Abstract Objectives To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. Methods The REACH Registry recruited &gt;68000 outpatients aged ≥45 years with established atherothrombotic disease or ≥3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. Results RF control was less frequent in patients with PAD ( n = 8322), compared with those with CAD or CVD (but no PAD, n = 47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P &lt; 0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR = 1.9); residence in North America (OR = 3.5), Japan (OR = 2.5) or Latin America (OR = 1.5); previous coronary revascularization (OR = 1.3); and statin use (OR = 1.4); whereas prior leg amputation was a negative predictor (OR = 0.7) ( P &lt; 0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events. Conclusions Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2008.10.023</identifier><identifier>PMID: 19054514</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aged ; Atherosclerosis - complications ; Atherosclerosis - therapy ; Cardiovascular ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention &amp; control ; Cardiovascular events ; Cerebrovascular Disorders - complications ; Cerebrovascular Disorders - therapy ; Cohort study ; Coronary Artery Disease - complications ; Coronary Artery Disease - therapy ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Peripheral artery disease ; Peripheral Vascular Diseases - complications ; Peripheral Vascular Diseases - therapy ; Proportional Hazards Models ; Prospective Studies ; REACH Registry ; Registries ; Risk Assessment ; Risk factor control ; Risk Factors ; Thrombosis - complications ; Thrombosis - therapy ; Time Factors</subject><ispartof>Atherosclerosis, 2009-06, Vol.204 (2), p.e86-e92</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-aef84da645efff27db7603f2b06184f68a47ed253ad5f723c7fecee32b98a3b63</citedby><cites>FETCH-LOGICAL-c483t-aef84da645efff27db7603f2b06184f68a47ed253ad5f723c7fecee32b98a3b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2008.10.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19054514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cacoub, Patrice P</creatorcontrib><creatorcontrib>Abola, Maria Teresa B</creatorcontrib><creatorcontrib>Baumgartner, Iris</creatorcontrib><creatorcontrib>Bhatt, Deepak L</creatorcontrib><creatorcontrib>Creager, Mark A</creatorcontrib><creatorcontrib>Liau, Chiau-Suong</creatorcontrib><creatorcontrib>Goto, Shinya</creatorcontrib><creatorcontrib>Röther, Joachim</creatorcontrib><creatorcontrib>Steg, P. Gabriel</creatorcontrib><creatorcontrib>Hirsch, Alan T</creatorcontrib><creatorcontrib>on behalf of the REACH Registry Investigators</creatorcontrib><creatorcontrib>REACH Registry Investigators</creatorcontrib><title>Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Objectives To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. Methods The REACH Registry recruited &gt;68000 outpatients aged ≥45 years with established atherothrombotic disease or ≥3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. Results RF control was less frequent in patients with PAD ( n = 8322), compared with those with CAD or CVD (but no PAD, n = 47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P &lt; 0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR = 1.9); residence in North America (OR = 3.5), Japan (OR = 2.5) or Latin America (OR = 1.5); previous coronary revascularization (OR = 1.3); and statin use (OR = 1.4); whereas prior leg amputation was a negative predictor (OR = 0.7) ( P &lt; 0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events. Conclusions Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.</description><subject>Aged</subject><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - therapy</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention &amp; control</subject><subject>Cardiovascular events</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Cerebrovascular Disorders - therapy</subject><subject>Cohort study</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Peripheral artery disease</subject><subject>Peripheral Vascular Diseases - complications</subject><subject>Peripheral Vascular Diseases - therapy</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>REACH Registry</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Risk factor control</subject><subject>Risk Factors</subject><subject>Thrombosis - complications</subject><subject>Thrombosis - therapy</subject><subject>Time Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk2LFDEQDaK44-pfkFwUPfSYr_6YgwtDs-4IC8Kq55BOKk5muzttkl6Yf-NPNb0zIOzJS3J4r-q9qlcIvaNkTQmtPh3WKu0h-Kj75XVxzQhpMrYmjD9DK9rUm4KKRjxHK0IYLTa0JBfoVYwHQoioafMSXdANKUVJxQr9aVUwzj-oqOdeBRxcvMdW6eQD1n5MwfdYjQb7OWk_QMRuxBMEN2UPKkMhQThi4yKoCHhSycGYHlnZJb4DM-vk_Ii9xdtH32kf_NAtxrHNGm3WcOMMBu9A9WmPP9xdb9vdx1z6y8UUjq_RC6v6CG_O_yX6-eX6R7srbr_dfG23t4UWDU-FAtsIoypRgrWW1aarK8It60hFG2GrRokaDCu5MqWtGde1BQ3AWbdpFO8qfonen_pOwf-eISY5uKih79UIfo6yqtmmLDnLxM8nos7rjwGsnIIbVDhKSuQSkTzIJxHJJaIFzhHl-rdnobkbwPyrPmeSCTcnAuRxHxwEGXXeqgbjAugkjXf_LXX1pJPu3ei06u_hCPHg5zDmnUoqI5NEfl_uZTkX0hBSi1LwvxzXxeU</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Cacoub, Patrice P</creator><creator>Abola, Maria Teresa B</creator><creator>Baumgartner, Iris</creator><creator>Bhatt, Deepak L</creator><creator>Creager, Mark A</creator><creator>Liau, Chiau-Suong</creator><creator>Goto, Shinya</creator><creator>Röther, Joachim</creator><creator>Steg, P. Gabriel</creator><creator>Hirsch, Alan T</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry</title><author>Cacoub, Patrice P ; Abola, Maria Teresa B ; Baumgartner, Iris ; Bhatt, Deepak L ; Creager, Mark A ; Liau, Chiau-Suong ; Goto, Shinya ; Röther, Joachim ; Steg, P. Gabriel ; Hirsch, Alan T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-aef84da645efff27db7603f2b06184f68a47ed253ad5f723c7fecee32b98a3b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - therapy</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - prevention &amp; control</topic><topic>Cardiovascular events</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Cerebrovascular Disorders - therapy</topic><topic>Cohort study</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Peripheral artery disease</topic><topic>Peripheral Vascular Diseases - complications</topic><topic>Peripheral Vascular Diseases - therapy</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>REACH Registry</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Risk factor control</topic><topic>Risk Factors</topic><topic>Thrombosis - complications</topic><topic>Thrombosis - therapy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cacoub, Patrice P</creatorcontrib><creatorcontrib>Abola, Maria Teresa B</creatorcontrib><creatorcontrib>Baumgartner, Iris</creatorcontrib><creatorcontrib>Bhatt, Deepak L</creatorcontrib><creatorcontrib>Creager, Mark A</creatorcontrib><creatorcontrib>Liau, Chiau-Suong</creatorcontrib><creatorcontrib>Goto, Shinya</creatorcontrib><creatorcontrib>Röther, Joachim</creatorcontrib><creatorcontrib>Steg, P. Gabriel</creatorcontrib><creatorcontrib>Hirsch, Alan T</creatorcontrib><creatorcontrib>on behalf of the REACH Registry Investigators</creatorcontrib><creatorcontrib>REACH Registry Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cacoub, Patrice P</au><au>Abola, Maria Teresa B</au><au>Baumgartner, Iris</au><au>Bhatt, Deepak L</au><au>Creager, Mark A</au><au>Liau, Chiau-Suong</au><au>Goto, Shinya</au><au>Röther, Joachim</au><au>Steg, P. Gabriel</au><au>Hirsch, Alan T</au><aucorp>on behalf of the REACH Registry Investigators</aucorp><aucorp>REACH Registry Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2009-06</date><risdate>2009</risdate><volume>204</volume><issue>2</issue><spage>e86</spage><epage>e92</epage><pages>e86-e92</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Objectives To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. Methods The REACH Registry recruited &gt;68000 outpatients aged ≥45 years with established atherothrombotic disease or ≥3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. Results RF control was less frequent in patients with PAD ( n = 8322), compared with those with CAD or CVD (but no PAD, n = 47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P &lt; 0.001)]. Factors independently associated with optimal RF control in patients with PAD were male gender (OR = 1.9); residence in North America (OR = 3.5), Japan (OR = 2.5) or Latin America (OR = 1.5); previous coronary revascularization (OR = 1.3); and statin use (OR = 1.4); whereas prior leg amputation was a negative predictor (OR = 0.7) ( P &lt; 0.001). Optimal RF control was associated with fewer 1-year CV ischemic symptoms or events. Conclusions Patients with PAD do not achieve RF control as frequently as individuals with CAD or CVD. Improved RF control is associated with a positive impact on 1-year CV event rates.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19054514</pmid><doi>10.1016/j.atherosclerosis.2008.10.023</doi></addata></record>
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subjects Aged
Atherosclerosis - complications
Atherosclerosis - therapy
Cardiovascular
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
Cardiovascular events
Cerebrovascular Disorders - complications
Cerebrovascular Disorders - therapy
Cohort study
Coronary Artery Disease - complications
Coronary Artery Disease - therapy
Female
Humans
Male
Middle Aged
Odds Ratio
Peripheral artery disease
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - therapy
Proportional Hazards Models
Prospective Studies
REACH Registry
Registries
Risk Assessment
Risk factor control
Risk Factors
Thrombosis - complications
Thrombosis - therapy
Time Factors
title Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry
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