A novel nano-porous alumina biomaterial with potential for loading with bioactive materials
Nano‐porous alumina, with the potential for being loaded with bioactive materials, has been proposed as a novel material for coating implants. In this study, the shear strength of the interface between such nano‐porous anodic aluminium oxide (AAO) coatings and titanium substrates, their biocompatibi...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2009-07, Vol.90A (1), p.46-54 |
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| container_title | Journal of biomedical materials research. Part A |
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| creator | Walpole, Andrew R. Xia, Zhidao Wilson, Crispian W. Triffitt, James T. Wilshaw, Peter R. |
| description | Nano‐porous alumina, with the potential for being loaded with bioactive materials, has been proposed as a novel material for coating implants. In this study, the shear strength of the interface between such nano‐porous anodic aluminium oxide (AAO) coatings and titanium substrates, their biocompatibility, and their potential for pore loading have been investigated. An interface shear strength in excess of 29 MPa was obtained which is comparable with that of conventional plasma sprayed hydroxyapatite implant coatings. The viability and differentiation of MG63 osteoblastic cells co‐cultured on the coating was found to be broadly comparable to that of similar cells co‐cultured on conventional bioinert implant materials such as titanium and fully dense alumina. Extensive pore loading with silica nano‐particles of different sizes and in different combinations was demonstrated throughout the thickness of AAO layers 1 μm and 60 μm thick. This work has demonstrated, that with suitable choice of pore filling materials, this novel coating might simultaneously combat infection, encourage bone regeneration, and secure fixation of the implant to bone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 |
| doi_str_mv | 10.1002/jbm.a.32067 |
| format | Article |
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In this study, the shear strength of the interface between such nano‐porous anodic aluminium oxide (AAO) coatings and titanium substrates, their biocompatibility, and their potential for pore loading have been investigated. An interface shear strength in excess of 29 MPa was obtained which is comparable with that of conventional plasma sprayed hydroxyapatite implant coatings. The viability and differentiation of MG63 osteoblastic cells co‐cultured on the coating was found to be broadly comparable to that of similar cells co‐cultured on conventional bioinert implant materials such as titanium and fully dense alumina. Extensive pore loading with silica nano‐particles of different sizes and in different combinations was demonstrated throughout the thickness of AAO layers 1 μm and 60 μm thick. This work has demonstrated, that with suitable choice of pore filling materials, this novel coating might simultaneously combat infection, encourage bone regeneration, and secure fixation of the implant to bone. © 2008 Wiley Periodicals, Inc. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Nano‐porous alumina, with the potential for being loaded with bioactive materials, has been proposed as a novel material for coating implants. In this study, the shear strength of the interface between such nano‐porous anodic aluminium oxide (AAO) coatings and titanium substrates, their biocompatibility, and their potential for pore loading have been investigated. An interface shear strength in excess of 29 MPa was obtained which is comparable with that of conventional plasma sprayed hydroxyapatite implant coatings. The viability and differentiation of MG63 osteoblastic cells co‐cultured on the coating was found to be broadly comparable to that of similar cells co‐cultured on conventional bioinert implant materials such as titanium and fully dense alumina. Extensive pore loading with silica nano‐particles of different sizes and in different combinations was demonstrated throughout the thickness of AAO layers 1 μm and 60 μm thick. This work has demonstrated, that with suitable choice of pore filling materials, this novel coating might simultaneously combat infection, encourage bone regeneration, and secure fixation of the implant to bone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</description><subject>Aluminum Oxide - chemistry</subject><subject>anodic aluminium oxide (AAO)</subject><subject>Cell Line, Tumor</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coculture Techniques</subject><subject>Drug Carriers - chemistry</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>nano-porous</subject><subject>osteoblastic cells</subject><subject>Osteoblasts - cytology</subject><subject>Osteoblasts - metabolism</subject><subject>Porosity</subject><subject>Prostheses and Implants</subject><subject>Stress, Mechanical</subject><subject>Tensile Strength</subject><subject>titanium</subject><subject>Titanium - chemistry</subject><issn>1549-3296</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxa2qVaELp96rnHpB2Tp2bMdHQJQPAe2BDwkO1iSZgCGJFzvLwn-Pt1nKDU4zo_m9J808Qr5ndJpRyn7dld0UppxRqT6R9UwIluZais_LPtcpZ1qukW8h3EVYUsG-krWsyItMabpOrreT3j1im_TQu3TmvJuHBNp5Z3tISus6GNBbaJOFHW6TmRuwH5Zj43zSOqhtfzOuIgvVYB8xeZWEDfKliQU3V3VCzn_vne0epMd_9g93t4_TKmdapWVZ5SgF1rTQHEtFC9VAo4VGpSTUquGUMUAGJeQVB2C6rgrZsCajQlRA-YT8HH1n3j3MMQyms6HCtoUe4zlGKqYZj-YfgTwXTMTPfAjGXxdSijyCWyNYeReCx8bMvO3AP5uMmmU6JqZjwPxLJ9I_VrbzssP6jV3FEYFsBBa2xef3vMzRzsmraTpqbBjw6b8G_H08nCthLk_3zeXF1QX9K09MwV8AlMurBA</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Walpole, Andrew R.</creator><creator>Xia, Zhidao</creator><creator>Wilson, Crispian W.</creator><creator>Triffitt, James T.</creator><creator>Wilshaw, Peter R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7QF</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>A novel nano-porous alumina biomaterial with potential for loading with bioactive materials</title><author>Walpole, Andrew R. ; Xia, Zhidao ; Wilson, Crispian W. ; Triffitt, James T. ; Wilshaw, Peter R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4297-bbc4e65ed0893eb7087faf959e776ad7f3022ae2aba4c3aa29dc86f2f1055ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aluminum Oxide - chemistry</topic><topic>anodic aluminium oxide (AAO)</topic><topic>Cell Line, Tumor</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coculture Techniques</topic><topic>Drug Carriers - chemistry</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>nano-porous</topic><topic>osteoblastic cells</topic><topic>Osteoblasts - cytology</topic><topic>Osteoblasts - metabolism</topic><topic>Porosity</topic><topic>Prostheses and Implants</topic><topic>Stress, Mechanical</topic><topic>Tensile Strength</topic><topic>titanium</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walpole, Andrew R.</creatorcontrib><creatorcontrib>Xia, Zhidao</creatorcontrib><creatorcontrib>Wilson, Crispian W.</creatorcontrib><creatorcontrib>Triffitt, James T.</creatorcontrib><creatorcontrib>Wilshaw, Peter R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Aluminium Industry Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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In this study, the shear strength of the interface between such nano‐porous anodic aluminium oxide (AAO) coatings and titanium substrates, their biocompatibility, and their potential for pore loading have been investigated. An interface shear strength in excess of 29 MPa was obtained which is comparable with that of conventional plasma sprayed hydroxyapatite implant coatings. The viability and differentiation of MG63 osteoblastic cells co‐cultured on the coating was found to be broadly comparable to that of similar cells co‐cultured on conventional bioinert implant materials such as titanium and fully dense alumina. Extensive pore loading with silica nano‐particles of different sizes and in different combinations was demonstrated throughout the thickness of AAO layers 1 μm and 60 μm thick. This work has demonstrated, that with suitable choice of pore filling materials, this novel coating might simultaneously combat infection, encourage bone regeneration, and secure fixation of the implant to bone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18481790</pmid><doi>10.1002/jbm.a.32067</doi><tpages>9</tpages></addata></record> |
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| subjects | Aluminum Oxide - chemistry anodic aluminium oxide (AAO) Cell Line, Tumor Coated Materials, Biocompatible - chemistry Coculture Techniques Drug Carriers - chemistry Humans Materials Testing nano-porous osteoblastic cells Osteoblasts - cytology Osteoblasts - metabolism Porosity Prostheses and Implants Stress, Mechanical Tensile Strength titanium Titanium - chemistry |
| title | A novel nano-porous alumina biomaterial with potential for loading with bioactive materials |
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