The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients
The aim was to investigate the effects of monochromatic and broadband stimuli on the amplitude of the photopic negative response (PhNR) and to compare the sensitivities of these stimuli for the detection of ganglion cell damage in glaucoma patients. Forty-one healthy subjects were studied, along wit...
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| Veröffentlicht in: | Documenta ophthalmologica 2009-06, Vol.118 (3), p.167-177 |
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| description | The aim was to investigate the effects of monochromatic and broadband stimuli on the amplitude of the photopic negative response (PhNR) and to compare the sensitivities of these stimuli for the detection of ganglion cell damage in glaucoma patients. Forty-one healthy subjects were studied, along with 16 patients with open-angle glaucoma. Photopic electroretinograms (ERGs) were elicited with monochromatic red, amber, green, and broadband white stimuli of progressively brighter intensities in a blue background. Pattern ERGs were also recorded using a 0.8° checkerboard pattern on a 21.6° × 27.8° screen. In the photopic ERGs of the control subjects, the PhNR amplitude was significantly higher (
P
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| doi_str_mv | 10.1007/s10633-008-9150-9 |
| format | Article |
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P
< 0.01) to red than to monochromatic amber, green, and broadband white stimuli of the same intensity. In glaucoma patients, the percentage of amplitude reduction was greater for the PhNR to red (68%,
P
< 0.001) than to the broadband stimulus (38%,
P
= 0.001). The PhNR to red monochromatic stimulus appeared to be a more sensitive parameter, with a larger area enclosed by the receiver-operating characteristic curve (0.97) than for the PhNR to broadband stimulus (0.76). Also, the PhNR to red stimulus showed a more significant correlation with the pattern ERG and the visual field defects (
P
< 0.05) than the PhNR elicited with broadband stimulus. These findings suggest that ganglion cell activity can be more efficiently evaluated with the PhNR elicited with a red than with a broadband stimulus. The PhNR thus appears to be a promising test for the diagnostics of the ganglion cell dysfunction.</description><identifier>ISSN: 0012-4486</identifier><identifier>EISSN: 1573-2622</identifier><identifier>DOI: 10.1007/s10633-008-9150-9</identifier><identifier>PMID: 18932006</identifier><identifier>CODEN: DOOPAA</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Biological and medical sciences ; Electroretinography - methods ; Female ; Glaucoma ; Glaucoma and intraocular pressure ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Research Article ; Photic Stimulation - methods ; Retinal Ganglion Cells ; ROC Curve ; Sensitivity and Specificity ; Young Adult</subject><ispartof>Documenta ophthalmologica, 2009-06, Vol.118 (3), p.167-177</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-cfcf2dfd823503bf4cd2850c57e7a1c8094fcfa24f83ce25d2bd299682181c43</citedby><cites>FETCH-LOGICAL-c496t-cfcf2dfd823503bf4cd2850c57e7a1c8094fcfa24f83ce25d2bd299682181c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10633-008-9150-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10633-008-9150-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21540419$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18932006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sustar, Maja</creatorcontrib><creatorcontrib>Cvenkel, Barbara</creatorcontrib><creatorcontrib>Brecelj, Jelka</creatorcontrib><title>The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients</title><title>Documenta ophthalmologica</title><addtitle>Doc Ophthalmol</addtitle><addtitle>Doc Ophthalmol</addtitle><description>The aim was to investigate the effects of monochromatic and broadband stimuli on the amplitude of the photopic negative response (PhNR) and to compare the sensitivities of these stimuli for the detection of ganglion cell damage in glaucoma patients. Forty-one healthy subjects were studied, along with 16 patients with open-angle glaucoma. Photopic electroretinograms (ERGs) were elicited with monochromatic red, amber, green, and broadband white stimuli of progressively brighter intensities in a blue background. Pattern ERGs were also recorded using a 0.8° checkerboard pattern on a 21.6° × 27.8° screen. In the photopic ERGs of the control subjects, the PhNR amplitude was significantly higher (
P
< 0.01) to red than to monochromatic amber, green, and broadband white stimuli of the same intensity. In glaucoma patients, the percentage of amplitude reduction was greater for the PhNR to red (68%,
P
< 0.001) than to the broadband stimulus (38%,
P
= 0.001). The PhNR to red monochromatic stimulus appeared to be a more sensitive parameter, with a larger area enclosed by the receiver-operating characteristic curve (0.97) than for the PhNR to broadband stimulus (0.76). Also, the PhNR to red stimulus showed a more significant correlation with the pattern ERG and the visual field defects (
P
< 0.05) than the PhNR elicited with broadband stimulus. These findings suggest that ganglion cell activity can be more efficiently evaluated with the PhNR elicited with a red than with a broadband stimulus. The PhNR thus appears to be a promising test for the diagnostics of the ganglion cell dysfunction.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Electroretinography - methods</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma and intraocular pressure</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Research Article</subject><subject>Photic Stimulation - methods</subject><subject>Retinal Ganglion Cells</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>0012-4486</issn><issn>1573-2622</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9q3DAQxkVpaTZJH6CXIgrNzelIlm3pWEL_QSCXvQtZHnm92JIr2YU-T180cnZpoFB6EIKZ33zfSB8hbxncMoDmY2JQl2UBIAvFKijUC7JjVVMWvOb8JdkBMF4IIesLcpnSEQBUw-RrcsGkKjlAvSO_9wek6BzahQZH2xhM1xrf0e1MwQd7iGEyy2BpWoZpHQcaPF3y0HwIS5hz3WOf-z-RRkxz8Ak3oY3AMavGEHEZfOijmejgqQ9xMiNNa3vM3fTkk8thRl8Y349I-9GsNnvSOcuiX9I1eeXMmPDN-b4i-y-f93ffivuHr9_vPt0XVqh6Kayzjneuk7ysoGydsB2XFdiqwcYwK0GJTBgunCwt8qrjbceVqiVnkllRXpGbk-wcw48V06KnIVkcR-MxrEnXDZd1k3_8fyCHuiortYHv_wKPYY0-v0FzJvLSeb0MsRNkY0gpotNzHCYTf2kGeotZn2LWOWa9xaxVnnl3Fl7bCbvniXOuGfhwBkyyZnTReDukPxxnlQDBNiF-4lJu-R7j84b_dn8EmYLC2A</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Sustar, Maja</creator><creator>Cvenkel, Barbara</creator><creator>Brecelj, Jelka</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients</title><author>Sustar, Maja ; Cvenkel, Barbara ; Brecelj, Jelka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-cfcf2dfd823503bf4cd2850c57e7a1c8094fcfa24f83ce25d2bd299682181c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Electroretinography - methods</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma and intraocular pressure</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Research Article</topic><topic>Photic Stimulation - methods</topic><topic>Retinal Ganglion Cells</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sustar, Maja</creatorcontrib><creatorcontrib>Cvenkel, Barbara</creatorcontrib><creatorcontrib>Brecelj, Jelka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Documenta ophthalmologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sustar, Maja</au><au>Cvenkel, Barbara</au><au>Brecelj, Jelka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients</atitle><jtitle>Documenta ophthalmologica</jtitle><stitle>Doc Ophthalmol</stitle><addtitle>Doc Ophthalmol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>118</volume><issue>3</issue><spage>167</spage><epage>177</epage><pages>167-177</pages><issn>0012-4486</issn><eissn>1573-2622</eissn><coden>DOOPAA</coden><abstract>The aim was to investigate the effects of monochromatic and broadband stimuli on the amplitude of the photopic negative response (PhNR) and to compare the sensitivities of these stimuli for the detection of ganglion cell damage in glaucoma patients. Forty-one healthy subjects were studied, along with 16 patients with open-angle glaucoma. Photopic electroretinograms (ERGs) were elicited with monochromatic red, amber, green, and broadband white stimuli of progressively brighter intensities in a blue background. Pattern ERGs were also recorded using a 0.8° checkerboard pattern on a 21.6° × 27.8° screen. In the photopic ERGs of the control subjects, the PhNR amplitude was significantly higher (
P
< 0.01) to red than to monochromatic amber, green, and broadband white stimuli of the same intensity. In glaucoma patients, the percentage of amplitude reduction was greater for the PhNR to red (68%,
P
< 0.001) than to the broadband stimulus (38%,
P
= 0.001). The PhNR to red monochromatic stimulus appeared to be a more sensitive parameter, with a larger area enclosed by the receiver-operating characteristic curve (0.97) than for the PhNR to broadband stimulus (0.76). Also, the PhNR to red stimulus showed a more significant correlation with the pattern ERG and the visual field defects (
P
< 0.05) than the PhNR elicited with broadband stimulus. These findings suggest that ganglion cell activity can be more efficiently evaluated with the PhNR elicited with a red than with a broadband stimulus. The PhNR thus appears to be a promising test for the diagnostics of the ganglion cell dysfunction.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18932006</pmid><doi>10.1007/s10633-008-9150-9</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Electroretinography - methods Female Glaucoma Glaucoma and intraocular pressure Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Male Medical sciences Medicine Medicine & Public Health Ophthalmology Original Research Article Photic Stimulation - methods Retinal Ganglion Cells ROC Curve Sensitivity and Specificity Young Adult |
| title | The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients |
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