Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance
This study determined the effects of exercise training on adaptations of skeletal muscle including fibre composition, capillarity, intra-muscular triglyceride concentration (IMTG), as well as glucose transporter 4 protein (GLUT4) and metabolic enzyme activities. Percutaneous muscle biopsies from the...
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| Veröffentlicht in: | European journal of applied physiology 2004-12, Vol.93 (3), p.353-358 |
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| creator | Kim, Hyo Jeong Lee, Jong Sam Kim, Chang Keun |
| description | This study determined the effects of exercise training on adaptations of skeletal muscle including fibre composition, capillarity, intra-muscular triglyceride concentration (IMTG), as well as glucose transporter 4 protein (GLUT4) and metabolic enzyme activities. Percutaneous muscle biopsies from the vastus lateralis muscle were obtained from non-obese elderly Korean men (n = 10; age range 58-67 years) with impaired glucose tolerance. Subjects performed 12 weeks of endurance exercise training (60-70% of the heart rate reserve). The training program improved the total GLUT4 protein expression (P < 0.01), decreased the IMTG, increased the fatty acid oxidation capacity, and the number of capillaries around type 1 fibres (P < 0.05), whereas no significant alteration was observed around type II fibres. All data are presented as the means together with the standard deviation. The results suggest that endurance training evokes morphological and biochemical changes in the skeletal muscle of elderly men with impaired glucose tolerance that may be considered to limit the development of type 2 diabetes. |
| doi_str_mv | 10.1007/s00421-004-1214-2 |
| format | Article |
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Percutaneous muscle biopsies from the vastus lateralis muscle were obtained from non-obese elderly Korean men (n = 10; age range 58-67 years) with impaired glucose tolerance. Subjects performed 12 weeks of endurance exercise training (60-70% of the heart rate reserve). The training program improved the total GLUT4 protein expression (P < 0.01), decreased the IMTG, increased the fatty acid oxidation capacity, and the number of capillaries around type 1 fibres (P < 0.05), whereas no significant alteration was observed around type II fibres. All data are presented as the means together with the standard deviation. The results suggest that endurance training evokes morphological and biochemical changes in the skeletal muscle of elderly men with impaired glucose tolerance that may be considered to limit the development of type 2 diabetes.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-004-1214-2</identifier><identifier>PMID: 15480742</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adaptation, Physiological - physiology ; Aged ; Body Weight ; Diabetes ; Exercise - physiology ; Gene Expression - physiology ; Glucose - metabolism ; Glucose Transporter Type 4 ; Humans ; Insulin ; Insulin Resistance - physiology ; Lipid Metabolism ; Lipid Peroxidation ; Male ; Middle Aged ; Monosaccharide Transport Proteins - metabolism ; Muscle Proteins - metabolism ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Standard deviation ; Triglycerides - metabolism</subject><ispartof>European journal of applied physiology, 2004-12, Vol.93 (3), p.353-358</ispartof><rights>Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-31fbf7d41c63db33a01acaf85e9e6835aa9d4b251f16dee397061f44eec7b2f93</citedby><cites>FETCH-LOGICAL-c355t-31fbf7d41c63db33a01acaf85e9e6835aa9d4b251f16dee397061f44eec7b2f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15480742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyo Jeong</creatorcontrib><creatorcontrib>Lee, Jong Sam</creatorcontrib><creatorcontrib>Kim, Chang Keun</creatorcontrib><title>Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><description>This study determined the effects of exercise training on adaptations of skeletal muscle including fibre composition, capillarity, intra-muscular triglyceride concentration (IMTG), as well as glucose transporter 4 protein (GLUT4) and metabolic enzyme activities. Percutaneous muscle biopsies from the vastus lateralis muscle were obtained from non-obese elderly Korean men (n = 10; age range 58-67 years) with impaired glucose tolerance. Subjects performed 12 weeks of endurance exercise training (60-70% of the heart rate reserve). The training program improved the total GLUT4 protein expression (P < 0.01), decreased the IMTG, increased the fatty acid oxidation capacity, and the number of capillaries around type 1 fibres (P < 0.05), whereas no significant alteration was observed around type II fibres. All data are presented as the means together with the standard deviation. The results suggest that endurance training evokes morphological and biochemical changes in the skeletal muscle of elderly men with impaired glucose tolerance that may be considered to limit the development of type 2 diabetes.</description><subject>Adaptation, Physiological - physiology</subject><subject>Aged</subject><subject>Body Weight</subject><subject>Diabetes</subject><subject>Exercise - physiology</subject><subject>Gene Expression - physiology</subject><subject>Glucose - metabolism</subject><subject>Glucose Transporter Type 4</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Standard deviation</subject><subject>Triglycerides - metabolism</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcuKFTEQhoMozkUfwI0EF-5aU0n6tpRh1IEBN7oO6aQyZkgnbZJG5zV8YnM4BwfcuKkE_q8-KH5CXgF7B4yN7wtjkkPXZgccZMefkHOQYu4Gwcenf_8wn5GLUu4ZYxOH6Tk5g15ObJT8nPy-dg5NpclR_IXZ-IK0Zu2jj3c0RbruxQSkd2E36RjFsqVcMVNJt5wq-kh1tNTHlh3oPehMg9-8pSbFirG2jGKwmMMDXTHSn75-p37dtM9oH9UpYLMbfEGeOR0Kvjy9l-Tbx-uvV5-72y-fbq4-3HZG9H3tBLjFjVaCGYRdhNAMtNFu6nHGYRK91rOVC-_BwWARxTyyAZyUiGZcuJvFJXl79LYzfuxYqlp9MRiCjpj2ooaRN80M_wVhlFMvB9nAN_-A92nPsR2hBhC9mOXEGwRHyORUSkantuxXnR8UMHWoVR1rVW2qQ63qsPP6JN6XFe3jxqlH8Qc9SaCw</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Kim, Hyo Jeong</creator><creator>Lee, Jong Sam</creator><creator>Kim, Chang Keun</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance</title><author>Kim, Hyo Jeong ; Lee, Jong Sam ; Kim, Chang Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-31fbf7d41c63db33a01acaf85e9e6835aa9d4b251f16dee397061f44eec7b2f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Aged</topic><topic>Body Weight</topic><topic>Diabetes</topic><topic>Exercise - physiology</topic><topic>Gene Expression - physiology</topic><topic>Glucose - metabolism</topic><topic>Glucose Transporter Type 4</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monosaccharide Transport Proteins - metabolism</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Standard deviation</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyo Jeong</creatorcontrib><creatorcontrib>Lee, Jong Sam</creatorcontrib><creatorcontrib>Kim, Chang Keun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyo Jeong</au><au>Lee, Jong Sam</au><au>Kim, Chang Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance</atitle><jtitle>European journal of applied physiology</jtitle><addtitle>Eur J Appl Physiol</addtitle><date>2004-12</date><risdate>2004</risdate><volume>93</volume><issue>3</issue><spage>353</spage><epage>358</epage><pages>353-358</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>This study determined the effects of exercise training on adaptations of skeletal muscle including fibre composition, capillarity, intra-muscular triglyceride concentration (IMTG), as well as glucose transporter 4 protein (GLUT4) and metabolic enzyme activities. Percutaneous muscle biopsies from the vastus lateralis muscle were obtained from non-obese elderly Korean men (n = 10; age range 58-67 years) with impaired glucose tolerance. Subjects performed 12 weeks of endurance exercise training (60-70% of the heart rate reserve). The training program improved the total GLUT4 protein expression (P < 0.01), decreased the IMTG, increased the fatty acid oxidation capacity, and the number of capillaries around type 1 fibres (P < 0.05), whereas no significant alteration was observed around type II fibres. All data are presented as the means together with the standard deviation. The results suggest that endurance training evokes morphological and biochemical changes in the skeletal muscle of elderly men with impaired glucose tolerance that may be considered to limit the development of type 2 diabetes.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15480742</pmid><doi>10.1007/s00421-004-1214-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adaptation, Physiological - physiology Aged Body Weight Diabetes Exercise - physiology Gene Expression - physiology Glucose - metabolism Glucose Transporter Type 4 Humans Insulin Insulin Resistance - physiology Lipid Metabolism Lipid Peroxidation Male Middle Aged Monosaccharide Transport Proteins - metabolism Muscle Proteins - metabolism Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Standard deviation Triglycerides - metabolism |
| title | Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance |
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