The delineation of target volumes for radiotherapy of lung cancer patients
Abstract Purpose Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods In thre...
Gespeichert in:
| Veröffentlicht in: | Radiotherapy and oncology 2009-06, Vol.91 (3), p.455-460 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 460 |
|---|---|
| container_issue | 3 |
| container_start_page | 455 |
| container_title | Radiotherapy and oncology |
| container_volume | 91 |
| creator | Vorwerk, Hilke Beckmann, Gabriele Bremer, Michael Degen, Maria Dietl, Barbara Fietkau, Rainer Gsänger, Tammo Hermann, Robert Michael Alfred Herrmann, Markus Karl Höller, Ulrike van Kampen, Michael Körber, Wolfgang Maier, Burkhard Martin, Thomas Metz, Michael Richter, Ronald Siekmeyer, Birgit Steder, Martin Wagner, Daniela Hess, Clemens Friedrich Weiss, Elisabeth Christiansen, Hans |
| description | Abstract Purpose Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and PTV in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results Agreement (overlap ⩾ 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group ROID where due to repeated discussions and uniform teaching a better agreement was achieved. |
| doi_str_mv | 10.1016/j.radonc.2009.03.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67281734</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0167814009001224</els_id><sourcerecordid>67281734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-3f85142605bf7183fad44fcbe236e731c0762624604d35391d18191982fb7f873</originalsourceid><addsrcrecordid>eNqFkU2LFDEURYMoTjv6D0Rq5a7K95J0JdkIMvjJgAvHdUinXmbSVlfapGqg_70pukFw4yqbc-8j5zL2GqFDwP7dvstuSJPvOIDpQHSA8gnboFamBa3VU7apmGo1SrhiL0rZAwAHoZ6zKzRCGOjNhn27e6BmoDFO5OaYpiaFZnb5nubmMY3LgUoTUm7qqZjmB8rueFqRcZnuG-8mT7k51iBNc3nJngU3Fnp1ea_Zz08f726-tLffP3-9-XDbeqlxbkXQW5S8h-0uKNQiuEHK4HfERU9KoAfV857LHuQgtsLggBoNGs3DTgWtxDV7e-495vR7oTLbQyyextFNlJZie8U1KiErKM-gz6mUTMEeczy4fLIIdnVo9_bs0K4OLQhbHdbYm0v_sjvQ8Dd0kVaB92eA6i8fI2VbfDXgaYiZ_GyHFP934d8CXweI3o2_6ERln5Y8VYMWbeEW7I91x3VGMADIuRR_ABzkmCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67281734</pqid></control><display><type>article</type><title>The delineation of target volumes for radiotherapy of lung cancer patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Vorwerk, Hilke ; Beckmann, Gabriele ; Bremer, Michael ; Degen, Maria ; Dietl, Barbara ; Fietkau, Rainer ; Gsänger, Tammo ; Hermann, Robert Michael ; Alfred Herrmann, Markus Karl ; Höller, Ulrike ; van Kampen, Michael ; Körber, Wolfgang ; Maier, Burkhard ; Martin, Thomas ; Metz, Michael ; Richter, Ronald ; Siekmeyer, Birgit ; Steder, Martin ; Wagner, Daniela ; Hess, Clemens Friedrich ; Weiss, Elisabeth ; Christiansen, Hans</creator><creatorcontrib>Vorwerk, Hilke ; Beckmann, Gabriele ; Bremer, Michael ; Degen, Maria ; Dietl, Barbara ; Fietkau, Rainer ; Gsänger, Tammo ; Hermann, Robert Michael ; Alfred Herrmann, Markus Karl ; Höller, Ulrike ; van Kampen, Michael ; Körber, Wolfgang ; Maier, Burkhard ; Martin, Thomas ; Metz, Michael ; Richter, Ronald ; Siekmeyer, Birgit ; Steder, Martin ; Wagner, Daniela ; Hess, Clemens Friedrich ; Weiss, Elisabeth ; Christiansen, Hans</creatorcontrib><description>Abstract Purpose Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and PTV in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results Agreement (overlap ⩾ 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group ROID where due to repeated discussions and uniform teaching a better agreement was achieved.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2009.03.014</identifier><identifier>PMID: 19339069</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; Delineation ; Hematology, Oncology and Palliative Medicine ; Humans ; Interobserver variability ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - pathology ; Lung Neoplasms - radiotherapy ; Observer Variation ; Radiation therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Target volume ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Radiotherapy and oncology, 2009-06, Vol.91 (3), p.455-460</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-3f85142605bf7183fad44fcbe236e731c0762624604d35391d18191982fb7f873</citedby><cites>FETCH-LOGICAL-c481t-3f85142605bf7183fad44fcbe236e731c0762624604d35391d18191982fb7f873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.radonc.2009.03.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19339069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vorwerk, Hilke</creatorcontrib><creatorcontrib>Beckmann, Gabriele</creatorcontrib><creatorcontrib>Bremer, Michael</creatorcontrib><creatorcontrib>Degen, Maria</creatorcontrib><creatorcontrib>Dietl, Barbara</creatorcontrib><creatorcontrib>Fietkau, Rainer</creatorcontrib><creatorcontrib>Gsänger, Tammo</creatorcontrib><creatorcontrib>Hermann, Robert Michael</creatorcontrib><creatorcontrib>Alfred Herrmann, Markus Karl</creatorcontrib><creatorcontrib>Höller, Ulrike</creatorcontrib><creatorcontrib>van Kampen, Michael</creatorcontrib><creatorcontrib>Körber, Wolfgang</creatorcontrib><creatorcontrib>Maier, Burkhard</creatorcontrib><creatorcontrib>Martin, Thomas</creatorcontrib><creatorcontrib>Metz, Michael</creatorcontrib><creatorcontrib>Richter, Ronald</creatorcontrib><creatorcontrib>Siekmeyer, Birgit</creatorcontrib><creatorcontrib>Steder, Martin</creatorcontrib><creatorcontrib>Wagner, Daniela</creatorcontrib><creatorcontrib>Hess, Clemens Friedrich</creatorcontrib><creatorcontrib>Weiss, Elisabeth</creatorcontrib><creatorcontrib>Christiansen, Hans</creatorcontrib><title>The delineation of target volumes for radiotherapy of lung cancer patients</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Abstract Purpose Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and PTV in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results Agreement (overlap ⩾ 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group ROID where due to repeated discussions and uniform teaching a better agreement was achieved.</description><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - radiotherapy</subject><subject>Delineation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Interobserver variability</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Observer Variation</subject><subject>Radiation therapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Target volume</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEURYMoTjv6D0Rq5a7K95J0JdkIMvjJgAvHdUinXmbSVlfapGqg_70pukFw4yqbc-8j5zL2GqFDwP7dvstuSJPvOIDpQHSA8gnboFamBa3VU7apmGo1SrhiL0rZAwAHoZ6zKzRCGOjNhn27e6BmoDFO5OaYpiaFZnb5nubmMY3LgUoTUm7qqZjmB8rueFqRcZnuG-8mT7k51iBNc3nJngU3Fnp1ea_Zz08f726-tLffP3-9-XDbeqlxbkXQW5S8h-0uKNQiuEHK4HfERU9KoAfV857LHuQgtsLggBoNGs3DTgWtxDV7e-495vR7oTLbQyyextFNlJZie8U1KiErKM-gz6mUTMEeczy4fLIIdnVo9_bs0K4OLQhbHdbYm0v_sjvQ8Dd0kVaB92eA6i8fI2VbfDXgaYiZ_GyHFP934d8CXweI3o2_6ERln5Y8VYMWbeEW7I91x3VGMADIuRR_ABzkmCg</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Vorwerk, Hilke</creator><creator>Beckmann, Gabriele</creator><creator>Bremer, Michael</creator><creator>Degen, Maria</creator><creator>Dietl, Barbara</creator><creator>Fietkau, Rainer</creator><creator>Gsänger, Tammo</creator><creator>Hermann, Robert Michael</creator><creator>Alfred Herrmann, Markus Karl</creator><creator>Höller, Ulrike</creator><creator>van Kampen, Michael</creator><creator>Körber, Wolfgang</creator><creator>Maier, Burkhard</creator><creator>Martin, Thomas</creator><creator>Metz, Michael</creator><creator>Richter, Ronald</creator><creator>Siekmeyer, Birgit</creator><creator>Steder, Martin</creator><creator>Wagner, Daniela</creator><creator>Hess, Clemens Friedrich</creator><creator>Weiss, Elisabeth</creator><creator>Christiansen, Hans</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>The delineation of target volumes for radiotherapy of lung cancer patients</title><author>Vorwerk, Hilke ; Beckmann, Gabriele ; Bremer, Michael ; Degen, Maria ; Dietl, Barbara ; Fietkau, Rainer ; Gsänger, Tammo ; Hermann, Robert Michael ; Alfred Herrmann, Markus Karl ; Höller, Ulrike ; van Kampen, Michael ; Körber, Wolfgang ; Maier, Burkhard ; Martin, Thomas ; Metz, Michael ; Richter, Ronald ; Siekmeyer, Birgit ; Steder, Martin ; Wagner, Daniela ; Hess, Clemens Friedrich ; Weiss, Elisabeth ; Christiansen, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-3f85142605bf7183fad44fcbe236e731c0762624604d35391d18191982fb7f873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Non-Small-Cell Lung - radiotherapy</topic><topic>Delineation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Interobserver variability</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Observer Variation</topic><topic>Radiation therapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Target volume</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vorwerk, Hilke</creatorcontrib><creatorcontrib>Beckmann, Gabriele</creatorcontrib><creatorcontrib>Bremer, Michael</creatorcontrib><creatorcontrib>Degen, Maria</creatorcontrib><creatorcontrib>Dietl, Barbara</creatorcontrib><creatorcontrib>Fietkau, Rainer</creatorcontrib><creatorcontrib>Gsänger, Tammo</creatorcontrib><creatorcontrib>Hermann, Robert Michael</creatorcontrib><creatorcontrib>Alfred Herrmann, Markus Karl</creatorcontrib><creatorcontrib>Höller, Ulrike</creatorcontrib><creatorcontrib>van Kampen, Michael</creatorcontrib><creatorcontrib>Körber, Wolfgang</creatorcontrib><creatorcontrib>Maier, Burkhard</creatorcontrib><creatorcontrib>Martin, Thomas</creatorcontrib><creatorcontrib>Metz, Michael</creatorcontrib><creatorcontrib>Richter, Ronald</creatorcontrib><creatorcontrib>Siekmeyer, Birgit</creatorcontrib><creatorcontrib>Steder, Martin</creatorcontrib><creatorcontrib>Wagner, Daniela</creatorcontrib><creatorcontrib>Hess, Clemens Friedrich</creatorcontrib><creatorcontrib>Weiss, Elisabeth</creatorcontrib><creatorcontrib>Christiansen, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vorwerk, Hilke</au><au>Beckmann, Gabriele</au><au>Bremer, Michael</au><au>Degen, Maria</au><au>Dietl, Barbara</au><au>Fietkau, Rainer</au><au>Gsänger, Tammo</au><au>Hermann, Robert Michael</au><au>Alfred Herrmann, Markus Karl</au><au>Höller, Ulrike</au><au>van Kampen, Michael</au><au>Körber, Wolfgang</au><au>Maier, Burkhard</au><au>Martin, Thomas</au><au>Metz, Michael</au><au>Richter, Ronald</au><au>Siekmeyer, Birgit</au><au>Steder, Martin</au><au>Wagner, Daniela</au><au>Hess, Clemens Friedrich</au><au>Weiss, Elisabeth</au><au>Christiansen, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The delineation of target volumes for radiotherapy of lung cancer patients</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>91</volume><issue>3</issue><spage>455</spage><epage>460</epage><pages>455-460</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Abstract Purpose Differences in the delineation of the gross target volume (GTV) and planning target volume (PTV) in patients with non-small-cell lung cancer are considerable. The focus of this work is on the analysis of observer-related reasons while controlling for other variables. Methods In three consecutive patients, eighteen physicians from fourteen different departments delineated the GTV and PTV in CT-slices using a detailed instruction for target delineation. Differences in the volumes, the delineated anatomic lymph node compartments and differences in every delineated pixel of the contoured volumes in the CT-slices (pixel-by-pixel-analysis) were evaluated for different groups: ten radiation oncologists from ten departments (ROs), four haematologic oncologists and chest physicians from four departments (HOs) and five radiation oncologists from one department (RO1D). Results Agreement (overlap ⩾ 70% of the contoured pixels) for the GTV and PTV delineation was found in 16.3% and 23.7% (ROs), 30.4% and 38.6% (HOs) and 32.8% and 35.9% (RO1D), respectively. Conclusion A large interobserver variability in the PTV and much more in the GTV delineation were observed in spite of a detailed instruction for delineation. The variability was smallest for group ROID where due to repeated discussions and uniform teaching a better agreement was achieved.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19339069</pmid><doi>10.1016/j.radonc.2009.03.014</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-8140 |
| ispartof | Radiotherapy and oncology, 2009-06, Vol.91 (3), p.455-460 |
| issn | 0167-8140 1879-0887 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67281734 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Delineation Hematology, Oncology and Palliative Medicine Humans Interobserver variability Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Observer Variation Radiation therapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Target volume Tomography, X-Ray Computed Treatment Outcome |
| title | The delineation of target volumes for radiotherapy of lung cancer patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T23%3A38%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20delineation%20of%20target%20volumes%20for%20radiotherapy%20of%20lung%20cancer%20patients&rft.jtitle=Radiotherapy%20and%20oncology&rft.au=Vorwerk,%20Hilke&rft.date=2009-06-01&rft.volume=91&rft.issue=3&rft.spage=455&rft.epage=460&rft.pages=455-460&rft.issn=0167-8140&rft.eissn=1879-0887&rft_id=info:doi/10.1016/j.radonc.2009.03.014&rft_dat=%3Cproquest_cross%3E67281734%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67281734&rft_id=info:pmid/19339069&rft_els_id=1_s2_0_S0167814009001224&rfr_iscdi=true |