Abundant extracellular myelin in the meninges of patients with multiple sclerosis

Background: In multiple sclerosis (MS) myelin debris has been observed within MS lesions, in cerebrospinal fluid and cervical lymph nodes, but the route of myelin transport out of the brain is unknown. Drainage of interstitial fluid from the brain parenchyma involves the perivascular spaces and lept...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2009-06, Vol.35 (3), p.283-295
Hauptverfasser:	Kooi, E.-J., Van Horssen, J., Witte, M. E., Amor, S., Bø, L., Dijkstra, C. D., Van Der Valk, P., Geurts, J. J. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenoleukodystrophy - metabolism Adrenoleukodystrophy - pathology Adult Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Biological and medical sciences Brain - blood supply Brain - metabolism Child Child, Preschool Dendritic Cells - metabolism extracellular Extracellular Space - chemistry Female Human viral diseases Humans Infectious diseases Macrophages - metabolism Male Medical sciences meninges Meninges - chemistry Meninges - pathology Meningitis - metabolism Meningitis - pathology Middle Aged multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis - pathology myelin Myelin Proteins - analysis Myelin Sheath - chemistry Myelin Sheath - pathology Neurology Stroke - metabolism Stroke - pathology Viral diseases Viral diseases of the nervous system
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