Endothelin-A Receptor Antagonism Promotes Decreased Vasodilation but has no Differential Effect on Coronary Artery Compliance in Hypertensive Patients

The importance of endothelin-1 in the pathophysiology of essential hypertension is unclear. We therefore examined whether there is a differential effect of endothelin-A antagonism on vasodilation and coronary artery compliance in hypertensive compared to normotensive patients. We examined atheroscle...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2004-11, Vol.44 Suppl 1 (Supplement 1), p.S85-S88
Hauptverfasser:	Kyriakides, Zenon, Kyrzopoulos, Stamatis, Paraskevaidis, Ioannis, Kolokathis, Fotis, Tsopotos, Ioannis, Lyras, Theodore, Kremastinos, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antihypertensive Agents - administration & dosage Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Compliance Coronary Vessels - drug effects Coronary Vessels - metabolism Coronary Vessels - physiopathology Endothelin A Receptor Antagonists Endothelin-1 - metabolism Female Humans Hypertension - drug therapy Hypertension - metabolism Hypertension - physiopathology Infusions, Parenteral Male Middle Aged Peptides, Cyclic - administration & dosage Peptides, Cyclic - therapeutic use Prospective Studies Receptor, Endothelin A - metabolism Treatment Outcome Ultrasonography, Interventional Vasodilation - drug effects
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