Histogenesis of carcinosarcoma and Establishment of Leiomyosarcoma Cell line (HTMMT) derived from Human Uterine Carcinosarcoma
A cell line designated HTMMT was established from the human uterine carcinosarcoma (composed of leiomyosarcoma and adenocarcinoma) of a 66‐year‐old Japanese woman. The cell line grew well and 83 serial passages were successively done within 24 months. The cell line contained spindle‐ or fibrous‐shap...
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| Veröffentlicht in: | Human cell : official journal of Human Cell Research Society 2004-09, Vol.17 (3), p.131-138 |
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| creator | ISHIWATA, Isamu ISHIWATA, Chieko SOMA, Masayuki IGUCHI, Megumi KIGUCHI, Kazushige TAMAGAWA, Tomoharu ISHIWATA, Iwao ISHIKAWA, Hiroshi |
| description | A cell line designated HTMMT was established from the human uterine carcinosarcoma (composed of leiomyosarcoma and adenocarcinoma) of a 66‐year‐old Japanese woman. The cell line grew well and 83 serial passages were successively done within 24 months. The cell line contained spindle‐ or fibrous‐shaped cells that revealed neoplastic and pleomorphic features, and multipled rapidly without contact inhibition. These cells were characterized as possessing myofibrils. The karyotype exhibited hyperploidy and the chromosome number was ranged from 87 to 100. The cells were transplanted into an immune‐depressed hamster cheek pouch or into nude mouse skin, but produced no tumors. We supported the combination theory for the histogenesis of the carcinosarcoma. |
| doi_str_mv | 10.1111/j.1749-0774.2004.tb00029.x |
| format | Article |
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The cell line grew well and 83 serial passages were successively done within 24 months. The cell line contained spindle‐ or fibrous‐shaped cells that revealed neoplastic and pleomorphic features, and multipled rapidly without contact inhibition. These cells were characterized as possessing myofibrils. The karyotype exhibited hyperploidy and the chromosome number was ranged from 87 to 100. The cells were transplanted into an immune‐depressed hamster cheek pouch or into nude mouse skin, but produced no tumors. We supported the combination theory for the histogenesis of the carcinosarcoma.</description><subject>Aged</subject><subject>Animals</subject><subject>Carcinosarcoma</subject><subject>Carcinosarcoma - pathology</subject><subject>Cell Culture Techniques - methods</subject><subject>Cell line</subject><subject>Cell Line, Tumor</subject><subject>Chromosome Mapping</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leiomyosarcoma</subject><subject>Leiomyosarcoma - genetics</subject><subject>Leiomyosarcoma - pathology</subject><subject>Mesocricetus</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Myofibrils - pathology</subject><subject>Neoplasm Transplantation</subject><subject>Ploidies</subject><subject>Uterine Neoplasms - pathology</subject><issn>0914-7470</issn><issn>1749-0774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE2P0zAQhi0EYsvCX0AWBwSHBH_WNQckFC0EqSsu7dmynTG4SuIlTmF74bfjqNUijvjgkTzPvB49CL2ipKblvDvUVAldEaVEzQgR9ewIIUzX94_Q6qH1GK2IpqJSQpEr9CznQ0GlWLOn6IrKjdTlWqHfbcxz-gYj5JhxCtjbyccx5VLSYLEdO3yTZ-v6mL8PMM4Ls4WYhtMD00Df4z6OgN-0u9vb3VvcwRR_QofDlAbcHgc74v1c3grS_JP_HD0Jts_w4lKv0f7Tza5pq-3Xz1-aj9vKs42iVSBSEyfXXkoiufOEQNBB6SAY5x2zTqngJFPWB6W8dGLTbaDjjljwQWjGr9Hrc-7dlH4cIc9miNmXve0I6ZjNWjGlOdcFfH8G_ZRyniCYuykOdjoZSsxi3xzMotgsis1i31zsm_sy_PLyy9EN0P0dveguwIcz8Cv2cPqPaNPuG8op_wP2t5b0</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>ISHIWATA, Isamu</creator><creator>ISHIWATA, Chieko</creator><creator>SOMA, Masayuki</creator><creator>IGUCHI, Megumi</creator><creator>KIGUCHI, Kazushige</creator><creator>TAMAGAWA, Tomoharu</creator><creator>ISHIWATA, Iwao</creator><creator>ISHIKAWA, Hiroshi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Histogenesis of carcinosarcoma and Establishment of Leiomyosarcoma Cell line (HTMMT) derived from Human Uterine Carcinosarcoma</title><author>ISHIWATA, Isamu ; ISHIWATA, Chieko ; SOMA, Masayuki ; IGUCHI, Megumi ; KIGUCHI, Kazushige ; TAMAGAWA, Tomoharu ; ISHIWATA, Iwao ; ISHIKAWA, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2871-f0590b56c55053bc00ef9f79f4233d2ab77fb527acf77c5b48d8ed3b0aecf4923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Carcinosarcoma</topic><topic>Carcinosarcoma - pathology</topic><topic>Cell Culture Techniques - methods</topic><topic>Cell line</topic><topic>Cell Line, Tumor</topic><topic>Chromosome Mapping</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leiomyosarcoma</topic><topic>Leiomyosarcoma - genetics</topic><topic>Leiomyosarcoma - pathology</topic><topic>Mesocricetus</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Myofibrils - pathology</topic><topic>Neoplasm Transplantation</topic><topic>Ploidies</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHIWATA, Isamu</creatorcontrib><creatorcontrib>ISHIWATA, Chieko</creatorcontrib><creatorcontrib>SOMA, Masayuki</creatorcontrib><creatorcontrib>IGUCHI, Megumi</creatorcontrib><creatorcontrib>KIGUCHI, Kazushige</creatorcontrib><creatorcontrib>TAMAGAWA, Tomoharu</creatorcontrib><creatorcontrib>ISHIWATA, Iwao</creatorcontrib><creatorcontrib>ISHIKAWA, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human cell : official journal of Human Cell Research Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIWATA, Isamu</au><au>ISHIWATA, Chieko</au><au>SOMA, Masayuki</au><au>IGUCHI, Megumi</au><au>KIGUCHI, Kazushige</au><au>TAMAGAWA, Tomoharu</au><au>ISHIWATA, Iwao</au><au>ISHIKAWA, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histogenesis of carcinosarcoma and Establishment of Leiomyosarcoma Cell line (HTMMT) derived from Human Uterine Carcinosarcoma</atitle><jtitle>Human cell : official journal of Human Cell Research Society</jtitle><addtitle>Hum Cell</addtitle><date>2004-09</date><risdate>2004</risdate><volume>17</volume><issue>3</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0914-7470</issn><eissn>1749-0774</eissn><abstract>A cell line designated HTMMT was established from the human uterine carcinosarcoma (composed of leiomyosarcoma and adenocarcinoma) of a 66‐year‐old Japanese woman. 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| source | MEDLINE; Wiley Online Library All Journals; SpringerLink Journals - AutoHoldings |
| subjects | Aged Animals Carcinosarcoma Carcinosarcoma - pathology Cell Culture Techniques - methods Cell line Cell Line, Tumor Chromosome Mapping Cricetinae Female Humans Karyotyping Leiomyosarcoma Leiomyosarcoma - genetics Leiomyosarcoma - pathology Mesocricetus Mice Mice, Inbred BALB C Myofibrils - pathology Neoplasm Transplantation Ploidies Uterine Neoplasms - pathology |
| title | Histogenesis of carcinosarcoma and Establishment of Leiomyosarcoma Cell line (HTMMT) derived from Human Uterine Carcinosarcoma |
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