Modulation of CD8 + T cell avidity by increasing the turnover of viral antigen during infection

The increased potency of high avidity CD8 + T cells for the clearance of viral infections has been well documented. We have previously reported the novel finding that intranasal infection with the paramyxovirus SV5 induces a CD8 + T cell response to the SV5 P protein that is almost exclusively of hi...

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