Antagonists of the P2X(7) receptor. From lead identification to drug development
Gespeichert in:
| Veröffentlicht in: | Journal of medicinal chemistry 2009-05, Vol.52 (10), p.3123-3141 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3141 |
|---|---|
| container_issue | 10 |
| container_start_page | 3123 |
| container_title | Journal of medicinal chemistry |
| container_volume | 52 |
| creator | Guile, Simon D Alcaraz, Lilian Birkinshaw, Timothy N Bowers, Keith C Ebden, Mark R Furber, Mark Stocks, Michael J |
| description | |
| doi_str_mv | 10.1021/jm801528x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67274758</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67274758</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-8ffeca6319c647fa103f5a154913e89c8f53f80cbc1c36ae6104069c81db932c3</originalsourceid><addsrcrecordid>eNo1kMFLwzAYxYMgbk4P_gOSk-ihM1_TtOlxDKfCwB0UvJU0_TIz2qYmqeh_b8HJO_zgvcc7PEKugC2BpXB_6CQDkcrvEzKfyJJMsmxGzkM4MMY4pPyMzKCcJKSYk92qj2rvehtioM7Q-IF0l77fFnfUo8YhOr-kG-862qJqqG2wj9ZYraJ1PY2ONn7c0wa_sHVDN4UX5NSoNuDlkQvytnl4XT8l25fH5_VqmwzAy5hIY1CrnEOp86wwChg3QoHISuAoSy2N4EYyXWvQPFeYA8tYPvnQ1CVPNV-Qm7_dwbvPEUOsOhs0tq3q0Y2hyou0yAohp-L1sTjWHTbV4G2n_E_1_wH_Bcx_Wq0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67274758</pqid></control><display><type>article</type><title>Antagonists of the P2X(7) receptor. From lead identification to drug development</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Guile, Simon D ; Alcaraz, Lilian ; Birkinshaw, Timothy N ; Bowers, Keith C ; Ebden, Mark R ; Furber, Mark ; Stocks, Michael J</creator><creatorcontrib>Guile, Simon D ; Alcaraz, Lilian ; Birkinshaw, Timothy N ; Bowers, Keith C ; Ebden, Mark R ; Furber, Mark ; Stocks, Michael J</creatorcontrib><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm801528x</identifier><identifier>PMID: 19191585</identifier><language>eng</language><publisher>United States</publisher><subject>Amides - chemistry ; Amides - pharmacology ; Amides - therapeutic use ; Amidines - chemistry ; Amidines - pharmacology ; Amidines - therapeutic use ; Animals ; Arthritis, Rheumatoid - drug therapy ; Azoles - chemistry ; Azoles - pharmacology ; Azoles - therapeutic use ; Drug Discovery ; Humans ; Purinergic P2 Receptor Antagonists ; Receptors, Purinergic P2X7 ; Structure-Activity Relationship</subject><ispartof>Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3123-3141</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19191585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guile, Simon D</creatorcontrib><creatorcontrib>Alcaraz, Lilian</creatorcontrib><creatorcontrib>Birkinshaw, Timothy N</creatorcontrib><creatorcontrib>Bowers, Keith C</creatorcontrib><creatorcontrib>Ebden, Mark R</creatorcontrib><creatorcontrib>Furber, Mark</creatorcontrib><creatorcontrib>Stocks, Michael J</creatorcontrib><title>Antagonists of the P2X(7) receptor. From lead identification to drug development</title><title>Journal of medicinal chemistry</title><addtitle>J Med Chem</addtitle><subject>Amides - chemistry</subject><subject>Amides - pharmacology</subject><subject>Amides - therapeutic use</subject><subject>Amidines - chemistry</subject><subject>Amidines - pharmacology</subject><subject>Amidines - therapeutic use</subject><subject>Animals</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Azoles - chemistry</subject><subject>Azoles - pharmacology</subject><subject>Azoles - therapeutic use</subject><subject>Drug Discovery</subject><subject>Humans</subject><subject>Purinergic P2 Receptor Antagonists</subject><subject>Receptors, Purinergic P2X7</subject><subject>Structure-Activity Relationship</subject><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMFLwzAYxYMgbk4P_gOSk-ihM1_TtOlxDKfCwB0UvJU0_TIz2qYmqeh_b8HJO_zgvcc7PEKugC2BpXB_6CQDkcrvEzKfyJJMsmxGzkM4MMY4pPyMzKCcJKSYk92qj2rvehtioM7Q-IF0l77fFnfUo8YhOr-kG-862qJqqG2wj9ZYraJ1PY2ONn7c0wa_sHVDN4UX5NSoNuDlkQvytnl4XT8l25fH5_VqmwzAy5hIY1CrnEOp86wwChg3QoHISuAoSy2N4EYyXWvQPFeYA8tYPvnQ1CVPNV-Qm7_dwbvPEUOsOhs0tq3q0Y2hyou0yAohp-L1sTjWHTbV4G2n_E_1_wH_Bcx_Wq0</recordid><startdate>20090528</startdate><enddate>20090528</enddate><creator>Guile, Simon D</creator><creator>Alcaraz, Lilian</creator><creator>Birkinshaw, Timothy N</creator><creator>Bowers, Keith C</creator><creator>Ebden, Mark R</creator><creator>Furber, Mark</creator><creator>Stocks, Michael J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090528</creationdate><title>Antagonists of the P2X(7) receptor. From lead identification to drug development</title><author>Guile, Simon D ; Alcaraz, Lilian ; Birkinshaw, Timothy N ; Bowers, Keith C ; Ebden, Mark R ; Furber, Mark ; Stocks, Michael J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-8ffeca6319c647fa103f5a154913e89c8f53f80cbc1c36ae6104069c81db932c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amides - chemistry</topic><topic>Amides - pharmacology</topic><topic>Amides - therapeutic use</topic><topic>Amidines - chemistry</topic><topic>Amidines - pharmacology</topic><topic>Amidines - therapeutic use</topic><topic>Animals</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Azoles - chemistry</topic><topic>Azoles - pharmacology</topic><topic>Azoles - therapeutic use</topic><topic>Drug Discovery</topic><topic>Humans</topic><topic>Purinergic P2 Receptor Antagonists</topic><topic>Receptors, Purinergic P2X7</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guile, Simon D</creatorcontrib><creatorcontrib>Alcaraz, Lilian</creatorcontrib><creatorcontrib>Birkinshaw, Timothy N</creatorcontrib><creatorcontrib>Bowers, Keith C</creatorcontrib><creatorcontrib>Ebden, Mark R</creatorcontrib><creatorcontrib>Furber, Mark</creatorcontrib><creatorcontrib>Stocks, Michael J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guile, Simon D</au><au>Alcaraz, Lilian</au><au>Birkinshaw, Timothy N</au><au>Bowers, Keith C</au><au>Ebden, Mark R</au><au>Furber, Mark</au><au>Stocks, Michael J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonists of the P2X(7) receptor. From lead identification to drug development</atitle><jtitle>Journal of medicinal chemistry</jtitle><addtitle>J Med Chem</addtitle><date>2009-05-28</date><risdate>2009</risdate><volume>52</volume><issue>10</issue><spage>3123</spage><epage>3141</epage><pages>3123-3141</pages><eissn>1520-4804</eissn><cop>United States</cop><pmid>19191585</pmid><doi>10.1021/jm801528x</doi><tpages>19</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1520-4804 |
| ispartof | Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3123-3141 |
| issn | 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67274758 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Amides - chemistry Amides - pharmacology Amides - therapeutic use Amidines - chemistry Amidines - pharmacology Amidines - therapeutic use Animals Arthritis, Rheumatoid - drug therapy Azoles - chemistry Azoles - pharmacology Azoles - therapeutic use Drug Discovery Humans Purinergic P2 Receptor Antagonists Receptors, Purinergic P2X7 Structure-Activity Relationship |
| title | Antagonists of the P2X(7) receptor. From lead identification to drug development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T06%3A35%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antagonists%20of%20the%20P2X(7)%20receptor.%20From%20lead%20identification%20to%20drug%20development&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Guile,%20Simon%20D&rft.date=2009-05-28&rft.volume=52&rft.issue=10&rft.spage=3123&rft.epage=3141&rft.pages=3123-3141&rft.eissn=1520-4804&rft_id=info:doi/10.1021/jm801528x&rft_dat=%3Cproquest_pubme%3E67274758%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67274758&rft_id=info:pmid/19191585&rfr_iscdi=true |