MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling

MFG-E8 (milk fat globule-epidermal growth factor 8) deficiency is strongly associated with acquisition of immune-mediated disorders due to the loss of tissue homeostasis. However, comparatively little is known regarding its functions in gastrointestinal tract disorders, in which immune homeostasis i...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-06, Vol.182 (11), p.7222-7232
Hauptverfasser:	Aziz, Md Monowar, Ishihara, Shunji, Mishima, Yoshiyuki, Oshima, Naoki, Moriyama, Ichiro, Yuki, Takafumi, Kadowaki, Yasunori, Rumi, Mohammad Azharul Karim, Amano, Yuji, Kinoshita, Yoshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - analysis Antigens, Surface - pharmacology Colitis Disease Models, Animal Focal Adhesion Protein-Tyrosine Kinases - metabolism Inflammation Integrin alphaVbeta3 - metabolism Intestines - pathology Mice Milk Proteins - analysis Milk Proteins - pharmacology NF-kappa B - analysis Osteopontin - metabolism Phosphorylation Signal Transduction - drug effects
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