APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q

Germ-line mutations of the APC gene are associated with familial adenomatous polyposis, and somatic mutations occur frequently in sporadic colorectal cancer. However, to abrogate APC function, both alleles must be inactivated. Recently, it has been demonstrated that epigenetic modification of the AP...

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Veröffentlicht in:	Cancer biology & therapy 2004-10, Vol.3 (10), p.960-964
Hauptverfasser:	Arnold, Christian N, Goel, Ajay, Niedzwiecki, Donna, Dowell, Jeannette M, Wasserman, Linda, Compton, Carolyn, Mayer, Robert J, Bertagnolli, Monica M, Boland, C Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli Protein - genetics Chromosomes, Human, Pair 5 - genetics Colon - metabolism Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Methylation DNA, Neoplasm - genetics Gene Expression Regulation, Neoplastic Gene Silencing Humans Loss of Heterozygosity Promoter Regions, Genetic - genetics Rectum - metabolism
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