Genome‐Wide Haplotype Association Mapping in Mice Identifies a Genetic Variant in CER1 Associated With BMD and Fracture in Southern Chinese Women

BMD is a heritable trait and risk indicator for osteoporosis. In this study, we used a genome‐wide haplotype association mapping (HAM) approach to identify a haplotype block within Cer1 that partitions inbred mice strains into high and low BMD groups. A cohort of 1083 high and low BMD human subjects...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2009-06, Vol.24 (6), p.1013-1021
Hauptverfasser:	Tang, Paul LF, Cheung, Ching‐Lung, Sham, Pak C, McClurg, Philip, Lee, Bob, Chan, Shut‐Yan, Smith, David K, Tanner, Julian A, Su, Andrew I, Cheah, Kathryn SE, Kung, Annie WC, Song, You‐Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals association Biological and medical sciences BMD Bone Density - genetics CER1 China Cohort Studies Cytokines - genetics Female fracture Fractures, Bone - genetics Fundamental and applied biological sciences. Psychology Genome-Wide Association Study Haplotypes Humans Immunohistochemistry In Situ Hybridization Mice Mice, Inbred Strains Polymorphism, Single Nucleotide Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Skeleton and joints southern Chinese women Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!