Cytokine Inhibition after Glucocorticoid Exposure in Healthy Men with Low versus High Basal Cortisol Levels

Objective: The balance between glucocorticoid (GC) release and GC sensitivity in target cells is believed to be important to maintain homeostasis in the neuroendocrine control of inflammation. We investigated the impact of in vivo exposure to adrenocorticotropic hormone (ACTH) and dexamethasone (DEX...

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Veröffentlicht in:	Neuroimmunomodulation 2009-01, Vol.16 (4), p.245-250
Hauptverfasser:	Lekander, Mats, Axén, Jennie, Knutsson, Urban, Olgart Höglund, Caroline, Werner, Sigbritt, Wikström, Ann-Charlotte, Stierna, Pontus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - metabolism Adrenocorticotropic Hormone - pharmacology Adult Cytokines - blood Dexamethasone - metabolism Dexamethasone - pharmacology Down-Regulation - drug effects Down-Regulation - immunology Glucocorticoids - metabolism Glucocorticoids - pharmacology Humans Hydrocortisone - analysis Hydrocortisone - blood Immune Tolerance - drug effects Immune Tolerance - immunology Inflammation - blood Inflammation - immunology Inflammation - physiopathology Interleukin-6 - blood Leukocytes - drug effects Leukocytes - immunology Leukocytes - secretion Male Medicin och hälsovetenskap Neurosecretory Systems - drug effects Neurosecretory Systems - immunology Neurosecretory Systems - physiopathology Original Paper Stress, Psychological - blood Stress, Psychological - immunology Stress, Psychological - physiopathology Tumor Necrosis Factor-alpha - blood
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