African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

African descended populations exhibit an increased prevalence of asthma and allergies compared to Europeans. One approach to distinguish between environmental and genetic explanations for this difference is to study relationships of asthma risk to individual admixture. We aimed to determine the admi...

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Veröffentlicht in:Human genetics 2009-06, Vol.125 (5-6), p.565-579
Hauptverfasser: Vergara, Candelaria, Caraballo, Luis, Mercado, Dilia, Jimenez, Silvia, Rojas, Winston, Rafaels, Nicholas, Hand, Tracey, Campbell, Monica, Tsai, Yuhjung J, Gao, Li, Duque, Constanza, Lopez, Sergio, Bedoya, Gabriel, Ruiz-Linares, Andrés, Barnes, Kathleen C
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container_end_page 579
container_issue 5-6
container_start_page 565
container_title Human genetics
container_volume 125
creator Vergara, Candelaria
Caraballo, Luis
Mercado, Dilia
Jimenez, Silvia
Rojas, Winston
Rafaels, Nicholas
Hand, Tracey
Campbell, Monica
Tsai, Yuhjung J
Gao, Li
Duque, Constanza
Lopez, Sergio
Bedoya, Gabriel
Ruiz-Linares, Andrés
Barnes, Kathleen C
description African descended populations exhibit an increased prevalence of asthma and allergies compared to Europeans. One approach to distinguish between environmental and genetic explanations for this difference is to study relationships of asthma risk to individual admixture. We aimed to determine the admixture proportions of a case-control sample from the Caribbean Coast of Colombia currently participating in genetic studies for asthma, and to test for population stratification and association between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 368 asthmatics and 365 non-asthmatics for 52 autosomal ancestry informative markers, six mtDNA haplogroups and nine haplogroups and five microsatellites in Y chromosome. Autosomal admixture proportions, population stratification, and associations between ancestry and the phenotypes were estimated by ADMIXMAP. The average admixture proportions among asthmatics were 42.8% European, 39.9% African and 17.2% Native American and among non-asthmatics they were 44.2% (P = 0.068), 37.6% (P = 0.007) and 18.1% (P = 0.050), respectively. In the total sample, the paternal contributions were 71% European, 25% African and 4.0% Native American and the maternal lineages were 56.8% Native American, and 20.2% African; 22.9% of the individuals carried other non-Native American mtDNA haplogroups. African ancestry was significantly associated with asthma (OR: 2.97; 95% CI: 1.08-8.08), high tIgE (OR: 1.9; 95% CI: 1.17-3.12) and socioeconomic status (OR = 0.64; 95% CI: 0.47-0.87). Significant population stratification was observed in this sample. Our findings indicate that genetic factors can explain the association between asthma and African ancestry and suggest that this sample is a useful resource for performing admixture mapping for asthma.
doi_str_mv 10.1007/s00439-009-0649-2
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One approach to distinguish between environmental and genetic explanations for this difference is to study relationships of asthma risk to individual admixture. We aimed to determine the admixture proportions of a case-control sample from the Caribbean Coast of Colombia currently participating in genetic studies for asthma, and to test for population stratification and association between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 368 asthmatics and 365 non-asthmatics for 52 autosomal ancestry informative markers, six mtDNA haplogroups and nine haplogroups and five microsatellites in Y chromosome. Autosomal admixture proportions, population stratification, and associations between ancestry and the phenotypes were estimated by ADMIXMAP. The average admixture proportions among asthmatics were 42.8% European, 39.9% African and 17.2% Native American and among non-asthmatics they were 44.2% (P = 0.068), 37.6% (P = 0.007) and 18.1% (P = 0.050), respectively. In the total sample, the paternal contributions were 71% European, 25% African and 4.0% Native American and the maternal lineages were 56.8% Native American, and 20.2% African; 22.9% of the individuals carried other non-Native American mtDNA haplogroups. African ancestry was significantly associated with asthma (OR: 2.97; 95% CI: 1.08-8.08), high tIgE (OR: 1.9; 95% CI: 1.17-3.12) and socioeconomic status (OR = 0.64; 95% CI: 0.47-0.87). Significant population stratification was observed in this sample. 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Caraballo, Luis ; Mercado, Dilia ; Jimenez, Silvia ; Rojas, Winston ; Rafaels, Nicholas ; Hand, Tracey ; Campbell, Monica ; Tsai, Yuhjung J ; Gao, Li ; Duque, Constanza ; Lopez, Sergio ; Bedoya, Gabriel ; Ruiz-Linares, Andrés ; Barnes, Kathleen C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-d1175133923e7cb0e52939aeb30b8c0abf6866254e6a689aacd14a717fbea57d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>19th century</topic><topic>Adolescent</topic><topic>Adult</topic><topic>African Continental Ancestry Group - genetics</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Colombia - epidemiology</topic><topic>Disease</topic><topic>DNA, Mitochondrial - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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One approach to distinguish between environmental and genetic explanations for this difference is to study relationships of asthma risk to individual admixture. We aimed to determine the admixture proportions of a case-control sample from the Caribbean Coast of Colombia currently participating in genetic studies for asthma, and to test for population stratification and association between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 368 asthmatics and 365 non-asthmatics for 52 autosomal ancestry informative markers, six mtDNA haplogroups and nine haplogroups and five microsatellites in Y chromosome. Autosomal admixture proportions, population stratification, and associations between ancestry and the phenotypes were estimated by ADMIXMAP. The average admixture proportions among asthmatics were 42.8% European, 39.9% African and 17.2% Native American and among non-asthmatics they were 44.2% (P = 0.068), 37.6% (P = 0.007) and 18.1% (P = 0.050), respectively. In the total sample, the paternal contributions were 71% European, 25% African and 4.0% Native American and the maternal lineages were 56.8% Native American, and 20.2% African; 22.9% of the individuals carried other non-Native American mtDNA haplogroups. African ancestry was significantly associated with asthma (OR: 2.97; 95% CI: 1.08-8.08), high tIgE (OR: 1.9; 95% CI: 1.17-3.12) and socioeconomic status (OR = 0.64; 95% CI: 0.47-0.87). Significant population stratification was observed in this sample. Our findings indicate that genetic factors can explain the association between asthma and African ancestry and suggest that this sample is a useful resource for performing admixture mapping for asthma.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19290544</pmid><doi>10.1007/s00439-009-0649-2</doi><tpages>15</tpages></addata></record>
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subjects 19th century
Adolescent
Adult
African Continental Ancestry Group - genetics
Asthma
Asthma - epidemiology
Asthma - genetics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Chromosomes, Human, Y - genetics
Chronic obstructive pulmonary disease, asthma
Classical genetics, quantitative genetics, hybrids
Colombia - epidemiology
Disease
DNA, Mitochondrial - genetics
European Continental Ancestry Group - genetics
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Gene Function
Genetic Markers
Genetic Predisposition to Disease
Genetics of eukaryotes. Biological and molecular evolution
Genetics, Population
Genotype
Health risk assessment
Hispanic Americans
Human
Human Genetics
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin E - genetics
Indians, North American - genetics
Male
Medical sciences
Metabolic Diseases
Microsatellite Repeats
Middle Aged
Minority & ethnic groups
Mitochondrial DNA
Molecular Medicine
Native Americans
Original Investigation
Pneumology
Risk Factors
Sequence Analysis, DNA
Social Class
Young Adult
title African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia
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