Sympathoadrenal mechanisms in the pathogenesis of sleep apnea-related hypertension
Obstructive sleep apnea-hypopnea (OSAH) is regarded as an increasingly common cause of sustained hypertension. The vast majority of mechanistic studies linking these entities have focused on the role of sympathoactivation. This review therefore addresses this purported mechanism by highlighting stud...
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| Veröffentlicht in: | Current hypertension reports 2009-06, Vol.11 (3), p.212-216 |
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| creator | Friedman, Oded Logan, Alexander G. |
| description | Obstructive sleep apnea-hypopnea (OSAH) is regarded as an increasingly common cause of sustained hypertension. The vast majority of mechanistic studies linking these entities have focused on the role of sympathoactivation. This review therefore addresses this purported mechanism by highlighting studies conducted in the past 5 years that speak to OSAH-related changes in sympathoregulation, independent of obesity, as well as the intervening players and pathways that may be relevant to such changes. Finally, studies with a focus on changes in sympathoregulation induced by continuous positive airway pressure (CPAP) therapy are discussed. Taken together, these findings strengthen the claim that the sympathoadrenal pressor system is essential for the development of the hypertensive state in individuals with OSAH. |
| doi_str_mv | 10.1007/s11906-009-0037-2 |
| format | Article |
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Taken together, these findings strengthen the claim that the sympathoadrenal pressor system is essential for the development of the hypertensive state in individuals with OSAH.</description><subject>Animals</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology</subject><subject>Disease Progression</subject><subject>Family Medicine</subject><subject>General Practice</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - etiology</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nephrology</subject><subject>Premature birth</subject><subject>Primary Care Medicine</subject><subject>Sleep apnea</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Apnea Syndromes - metabolism</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sympathetic Nervous System - physiopathology</subject><issn>1522-6417</issn><issn>1534-3111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBdZPHhbzSTbZPco4hcUBD_OId3Mtlt2s2tme-i_N7WFguBhyIR53neSl7FL4LfAub4jgIKrlPMiltSpOGJjmMoslQBwvO2FSFUGesTOiFaci6jSp2wERZYJKWHM3j82bW-HZWddQG-bpMVyaX1NLSW1T4YlJr_jBXqkmpKuSqhB7BPbe7RpwMYO6JLlpscwoKe68-fspLIN4cX-nLCvp8fPh5d09vb8-nA_S0upiiF1LleyLEHFt1Rc8kzzMs81d5JjLufTXIGLF8gRnJ0WCmypHFbOyawSQs7lhN3sfPvQfa-RBtPWVGLTWI_dmozSQimtpxG8_gOuunWInyWT60KpQskiQrCDytARBaxMH-rWho0BbrZpm13aJqZttmkbETVXe-P1vEV3UOzjjYDYARRHfoHhsPl_1x9Q34pb</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Friedman, Oded</creator><creator>Logan, Alexander G.</creator><general>Current Science Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Sympathoadrenal mechanisms in the pathogenesis of sleep apnea-related hypertension</title><author>Friedman, Oded ; 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| ispartof | Current hypertension reports, 2009-06, Vol.11 (3), p.212-216 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Blood Pressure - physiology Cardiology Disease Progression Family Medicine General Practice Humans Hypertension Hypertension - etiology Hypertension - metabolism Hypertension - physiopathology Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Nephrology Premature birth Primary Care Medicine Sleep apnea Sleep Apnea Syndromes - complications Sleep Apnea Syndromes - metabolism Sleep Apnea Syndromes - physiopathology Sympathetic Nervous System - physiopathology |
| title | Sympathoadrenal mechanisms in the pathogenesis of sleep apnea-related hypertension |
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