Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Beating anti-fungal defences Immunocompromised individuals are at high risk from fungal infection, yet the molecular mechanisms that govern host defence against fungi are not well understood. Gross et al . now show that Candida albicans infection in mice activates the NALP3 inflammasome via a mechan...

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Veröffentlicht in:	Nature 2009-05, Vol.459 (7245), p.433-436
Hauptverfasser:	Gross, Olaf, Poeck, Hendrik, Bscheider, Michael, Dostert, Catherine, Hannesschläger, Nicole, Endres, Stefan, Hartmann, Gunther, Tardivel, Aubry, Schweighoffer, Edina, Tybulewicz, Victor, Mocsai, Attila, Tschopp, Jürg, Ruland, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Candida albicans Candida albicans - immunology Candida albicans - physiology Carrier Proteins - immunology Carrier Proteins - metabolism Caspase 1 - metabolism Cells Cellular control mechanisms Clinical trials E coli Enzyme Activation Fungi Humanities and Social Sciences Humans Immune system Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Inflammation - immunology Interleukin-1beta - biosynthesis Interleukin-1beta - immunology Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases letter Macrophages - metabolism Mammals Medical sciences Mice Monocytes - metabolism multidisciplinary Mycoses Nigericin - pharmacology NLR Family, Pyrin Domain-Containing 3 Protein Pattern recognition Phosphotransferases Pneumocystis carinii Potassium - metabolism Properties Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proteins R&D Reactive Oxygen Species - metabolism Research & development Salmonella typhimurium Science Science (multidisciplinary) Signal Transduction Studies Syk Kinase Toxins
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