Postnatal Glucocorticoid Excess Due to Pituitary Glucocorticoid Receptor Deficiency: Differential Short- and Long-Term Consequences

A tight regulation of hypothalamic-pituitary-adrenal (HPA) axis activity is essential for successful adaptation to stressful stimuli. Disruption of normal HPA axis development is a main risk factor for diseases such as posttraumatic stress disorder or depression, but the molecular mechanisms that le...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-06, Vol.150 (6), p.2709-2716
Hauptverfasser:	Schmidt, Mathias V, Sterlemann, Vera, Wagner, Klaus, Niederleitner, Bertram, Ganea, Karin, Liebl, Claudia, Deussing, Jan M, Berger, Stefan, Schütz, Günther, Holsboer, Florian, Müller, Marianne B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological - physiology Aging - metabolism Aging - psychology Animals Animals, Newborn - metabolism Anxiety Biological and medical sciences Cognition Cognitive ability Coping behavior Corticosterone Corticosterone - metabolism Corticotropin-Releasing Hormone - metabolism Feedback Feedback, Physiological - physiology Fundamental and applied biological sciences. Psychology Gene Deletion Gene expression Glucocorticoid receptors Glucocorticoids Glucocorticoids - metabolism Hormone Antagonists - pharmacology Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - metabolism Hypothalamus Male Mental disorders Mice Mice, Knockout Mifepristone - pharmacology Models, Animal Molecular modelling Negative feedback Neonates Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Pituitary Pituitary Gland - metabolism Pituitary-Adrenal System - metabolism Post traumatic stress disorder Postpartum period Psychological stress Receptors Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - deficiency Receptors, Glucocorticoid - genetics Risk factors Vasopressin Vasopressins - metabolism Vertebrates: endocrinology
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