Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus
Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus...
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| Veröffentlicht in: | Journal of neurovirology 2004-12, Vol.10 (6), p.387-399 |
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| creator | Marcario, JK Manaye, KF SantaCruz, KS Mouton, PR Berman, NEJ Cheney, PD |
| description | Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV infection, affected monkeys show clinical symptoms and neurological complications that mimic those observed in human neuro-AIDS. To investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (GP) and for dopamine (DA)-containing neurons in the substantia nigra (SN) in eight macaques inoculated with macrophage-tropic, neurovirulent SIV (SIVmac R71/17E), and five control animals. There was a significant difference between rapid progressors and controls for both neuron number (P |
| doi_str_mv | 10.1080/13550280490521131 |
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In the simian immunodeficiency virus (SIV) model of HIV infection, affected monkeys show clinical symptoms and neurological complications that mimic those observed in human neuro-AIDS. To investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (GP) and for dopamine (DA)-containing neurons in the substantia nigra (SN) in eight macaques inoculated with macrophage-tropic, neurovirulent SIV (SIVmac R71/17E), and five control animals. There was a significant difference between rapid progressors and controls for both neuron number (P <. 01) and neuronal density (P <. 05) in the GP, and for neuron number (P <. 05) in the SN. Neuron loss ranged from 6% to 70% in the GP and from 10% to 50% in the SN. Neuropathological analyses confirmed neuroAIDS-like changes in brain, including microglial nodules, extensive perivascular cuffing and/or the presence of multinucleated giant cells, and alterations in neuronal morphology in the majority of the rapid progressors. By comparison, slow progressors showed little, if any, neuropathology. These neuropathological changes in SIV-infected monkeys indicate that neuron death and morphological alterations in the basal ganglia may contribute to the motor impairments reported in the SIV model and, by analogy, in the subset of patients afflicted with motor impairment in human neuro-AIDS.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1080/13550280490521131</identifier><identifier>PMID: 15765810</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Animals ; Basal Ganglia - pathology ; Basal Ganglia - virology ; Biological and medical sciences ; Brain - pathology ; Brain - virology ; Cell Count ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Globus Pallidus - pathology ; Globus Pallidus - virology ; Human immunodeficiency virus 1 ; Human viral diseases ; Infectious diseases ; Macaca ; Macaca mulatta ; Male ; Medical sciences ; Nerve Degeneration - pathology ; Neurology ; Neurons - pathology ; Psychomotor Performance - physiology ; Simian Acquired Immunodeficiency Syndrome - pathology ; Simian Acquired Immunodeficiency Syndrome - physiopathology ; Simian Immunodeficiency Virus ; Substantia Nigra - pathology ; Substantia Nigra - virology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral diseases of the nervous system</subject><ispartof>Journal of neurovirology, 2004-12, Vol.10 (6), p.387-399</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-e154f994b898c435ad8b0ccf5b6c0088e0f400c0ae300b5c842f5818a62b585e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13550280490521131$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13550280490521131$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16335880$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15765810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcario, JK</creatorcontrib><creatorcontrib>Manaye, KF</creatorcontrib><creatorcontrib>SantaCruz, KS</creatorcontrib><creatorcontrib>Mouton, PR</creatorcontrib><creatorcontrib>Berman, NEJ</creatorcontrib><creatorcontrib>Cheney, PD</creatorcontrib><title>Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus</title><title>Journal of neurovirology</title><addtitle>J Neurovirol</addtitle><description>Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. In the simian immunodeficiency virus (SIV) model of HIV infection, affected monkeys show clinical symptoms and neurological complications that mimic those observed in human neuro-AIDS. To investigate the relationship between morphological correlates and neurophysiological deficits, unbiased stereology was used to assess total neuron number, volume, and neuronal density for all neurons in the globus pallidus (GP) and for dopamine (DA)-containing neurons in the substantia nigra (SN) in eight macaques inoculated with macrophage-tropic, neurovirulent SIV (SIVmac R71/17E), and five control animals. There was a significant difference between rapid progressors and controls for both neuron number (P <. 01) and neuronal density (P <. 05) in the GP, and for neuron number (P <. 05) in the SN. Neuron loss ranged from 6% to 70% in the GP and from 10% to 50% in the SN. Neuropathological analyses confirmed neuroAIDS-like changes in brain, including microglial nodules, extensive perivascular cuffing and/or the presence of multinucleated giant cells, and alterations in neuronal morphology in the majority of the rapid progressors. By comparison, slow progressors showed little, if any, neuropathology. These neuropathological changes in SIV-infected monkeys indicate that neuron death and morphological alterations in the basal ganglia may contribute to the motor impairments reported in the SIV model and, by analogy, in the subset of patients afflicted with motor impairment in human neuro-AIDS.</description><subject>Animals</subject><subject>Basal Ganglia - pathology</subject><subject>Basal Ganglia - virology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - virology</subject><subject>Cell Count</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Globus Pallidus - pathology</subject><subject>Globus Pallidus - virology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Infectious diseases</subject><subject>Macaca</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Degeneration - pathology</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Psychomotor Performance - physiology</subject><subject>Simian Acquired Immunodeficiency Syndrome - pathology</subject><subject>Simian Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Simian Immunodeficiency Virus</subject><subject>Substantia Nigra - pathology</subject><subject>Substantia Nigra - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral diseases of the nervous system</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utr3DAQB3BRGppH-wF6Kb40Nycj67EyPYWQFwRySHs28njUVbClVLI35NtXyy7kEGhPGtBvhtFfjH3lcMbBwDkXSkFjQLagGs4F_8COuBKmbqQUH0td7usC5CE7zvkJgAvdmE_skKuVVobDEaNH2lCiKi89xjR7tGM10G8KlOzsY6h8qCaL9s9CudSOcKahevHzugq0pLjxaRkpzFX2k7eFT9MS4kDOo6eAr9UW5M_swNkx05f9ecJ-XV_9vLyt7x9u7i4v7muUvJlr4kq6tpW9aQ1KoexgekB0qtcIYAyBkwAIlgRAr9DIxpVnGKubXhlF4oSd7uY-p7jdeO4mn5HG0QaKS-70qtFyxfV_IV9JI1stC-Q7iCnmnMh1z8lPNr12HLrtJ3TvPqH0fNsPX_qJhreOfeoFfN8Dm0vgLtmAPr85LYQyZut-7FwJPqbJrsmO8xptou4pLimUKP-xxl8ALaKm</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Marcario, JK</creator><creator>Manaye, KF</creator><creator>SantaCruz, KS</creator><creator>Mouton, PR</creator><creator>Berman, NEJ</creator><creator>Cheney, PD</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus</title><author>Marcario, JK ; Manaye, KF ; SantaCruz, KS ; Mouton, PR ; Berman, NEJ ; Cheney, PD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-e154f994b898c435ad8b0ccf5b6c0088e0f400c0ae300b5c842f5818a62b585e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Basal Ganglia - pathology</topic><topic>Basal Ganglia - virology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - virology</topic><topic>Cell Count</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Globus Pallidus - pathology</topic><topic>Globus Pallidus - virology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Infectious diseases</topic><topic>Macaca</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Degeneration - pathology</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Psychomotor Performance - physiology</topic><topic>Simian Acquired Immunodeficiency Syndrome - pathology</topic><topic>Simian Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Simian Immunodeficiency Virus</topic><topic>Substantia Nigra - pathology</topic><topic>Substantia Nigra - virology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcario, JK</creatorcontrib><creatorcontrib>Manaye, KF</creatorcontrib><creatorcontrib>SantaCruz, KS</creatorcontrib><creatorcontrib>Mouton, PR</creatorcontrib><creatorcontrib>Berman, NEJ</creatorcontrib><creatorcontrib>Cheney, PD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcario, JK</au><au>Manaye, KF</au><au>SantaCruz, KS</au><au>Mouton, PR</au><au>Berman, NEJ</au><au>Cheney, PD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus</atitle><jtitle>Journal of neurovirology</jtitle><addtitle>J Neurovirol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>10</volume><issue>6</issue><spage>387</spage><epage>399</epage><pages>387-399</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>Infection with human immunodeficiency virus-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS) in humans, causes a spectrum of neuropathology that includes alterations in behavior, changes in evoked potentials, and neuronal degeneration. 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Neuropathological analyses confirmed neuroAIDS-like changes in brain, including microglial nodules, extensive perivascular cuffing and/or the presence of multinucleated giant cells, and alterations in neuronal morphology in the majority of the rapid progressors. By comparison, slow progressors showed little, if any, neuropathology. These neuropathological changes in SIV-infected monkeys indicate that neuron death and morphological alterations in the basal ganglia may contribute to the motor impairments reported in the SIV model and, by analogy, in the subset of patients afflicted with motor impairment in human neuro-AIDS.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>15765810</pmid><doi>10.1080/13550280490521131</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of neurovirology, 2004-12, Vol.10 (6), p.387-399 |
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| subjects | Animals Basal Ganglia - pathology Basal Ganglia - virology Biological and medical sciences Brain - pathology Brain - virology Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Globus Pallidus - pathology Globus Pallidus - virology Human immunodeficiency virus 1 Human viral diseases Infectious diseases Macaca Macaca mulatta Male Medical sciences Nerve Degeneration - pathology Neurology Neurons - pathology Psychomotor Performance - physiology Simian Acquired Immunodeficiency Syndrome - pathology Simian Acquired Immunodeficiency Syndrome - physiopathology Simian Immunodeficiency Virus Substantia Nigra - pathology Substantia Nigra - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases of the nervous system |
| title | Severe subcortical degeneration in macaques infected with neurovirulent simian immunodeficiency virus |
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