Increased Exposure to Estrogens Disturbs Maturation, Steroidogenesis, and Cholesterol Homeostasis via Estrogen Receptor α in Adult Mouse Leydig Cells

Deteriorated male reproductive health has been connected to overexposure to estrogens or to imbalanced androgen-estrogen ratio. Transgenic male mice expressing human aromatase (AROM+ mice) serve as an apt model for the study of the consequences of an altered androgen-estrogen ratio. Our previous stu...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-06, Vol.150 (6), p.2865-2872
Hauptverfasser:	Strauss, Leena, Kallio, Jenny, Desai, Nimisha, Pakarinen, Pirjo, Miettinen, Tatu, Gylling, Helena, Albrecht, Martin, Mäkelä, Sari, Mayerhofer, Artur, Poutanen, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Androgens Animals Aromatase Aromatase - genetics Aromatase - metabolism Biological and medical sciences Cholesterol Cholesterol - metabolism Cryptorchidism Developmental stages Endoplasmic reticulum Estradiol Dehydrogenases - metabolism Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Estrogen receptors Estrogens Estrogens - metabolism Estrogens - pharmacology Extracellular matrix Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Homeostasis Homeostasis - drug effects Homeostasis - physiology Infertility Leydig cells Leydig Cells - drug effects Leydig Cells - metabolism Luteinizing Hormone - blood Male Males Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Animal Phosphoproteins - metabolism Receptors Reproductive health Sexual Maturation - drug effects Sexual Maturation - physiology Steroid 17-alpha-Hydroxylase - metabolism Steroidogenesis Steroids - metabolism Structure-function relationships Testosterone - metabolism Transgenic mice Vertebrates: endocrinology
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