Frequency of statin use in type 2 diabetics having macrovascular disease- at a Tertiary Care Hospital of Karachi

During the last two decades with the introduction of statins large reductions in cholesterol concentrations were easily and safely achievable and this led to studies that demonstrated benefits of statin use. But only fewer than one fourth of adults with coronary heart disease were receiving lipid-lo...

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Veröffentlicht in:Journal of Ayub Medical College, Abbottabad Abbottabad, 2004-10, Vol.16 (4), p.60-64
Hauptverfasser: Basit, Abdul, Hydrie, M Zafar Iqbal, Hakeem, Rubina, Ahmedani, M Yakoob, Masood, Qamar
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container_end_page 64
container_issue 4
container_start_page 60
container_title Journal of Ayub Medical College, Abbottabad
container_volume 16
creator Basit, Abdul
Hydrie, M Zafar Iqbal
Hakeem, Rubina
Ahmedani, M Yakoob
Masood, Qamar
description During the last two decades with the introduction of statins large reductions in cholesterol concentrations were easily and safely achievable and this led to studies that demonstrated benefits of statin use. But only fewer than one fourth of adults with coronary heart disease were receiving lipid-lowering drugs in a cross sectional health survey done in England. Thus this study was designed to evaluate the frequency of statin use in type 2 Pakistani diabetic subjects with macrovascular disease attending a tertiary care unit in Karachi, Pakistan. Records of type 2 diabetic subjects coming to the outpatient department of Baqai Institute of Diabetology and Endocrinology from September 1996 to December 2001 was analyzed for their anthropometric and biochemical characteristics. Patients having any macrovascular disease were identified and frequency of statin use by these subjects was studied. Out of a total of 2152 patients 502 (252 males, 250 females) having macrovascular disease were identified. Only 16.5% of them (44 males, 39 females) were taking statins. Use of statins was higher amongst those who had angina (20%) or myocardial infarction (17%) compared to those who had stroke (10%). Sixty two percent of the users while 52% of the non-users had elevated blood cholesterol. Frequency of statin use in the subjects studied was much lower than was warranted with respect to their disease status. Presence of elevated blood cholesterol despite using statins suggested inappropriate treatment in these subjects. Further studies are required to identify the factors leading to low use of statins in type 2 diabetic subjects with macrovascular symptoms.
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Sixty two percent of the users while 52% of the non-users had elevated blood cholesterol. Frequency of statin use in the subjects studied was much lower than was warranted with respect to their disease status. Presence of elevated blood cholesterol despite using statins suggested inappropriate treatment in these subjects. 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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Age Distribution
Aged
Ambulatory Care
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Cohort Studies
Developing Countries
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - drug therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Utilization
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia - epidemiology
Hypercholesterolemia - prevention & control
Hypoglycemic Agents - therapeutic use
Incidence
Male
Middle Aged
Pakistan - epidemiology
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Treatment Outcome
title Frequency of statin use in type 2 diabetics having macrovascular disease- at a Tertiary Care Hospital of Karachi
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