Atorvastatin Prevents Endothelial Dysfunction in Mesenteric Arteries From Spontaneously Hypertensive Rats: Role of Cyclooxygenase 2–Derived Contracting Prostanoids

We investigated the effect of atorvastatin on cyclooxygenase (COX) contribution to endothelial dysfunction in spontaneously hypertensive rat (SHR) mesenteric resistance arteries. Atorvastatin (10 mg/kg per day, oral gavage) or its vehicle was administered for 2 weeks to male SHR or Wistar-Kyoto rats...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2009-06, Vol.53 (6), p.1008-1016
Hauptverfasser:	Virdis, Agostino, Colucci, Rocchina, Versari, Daniele, Ghisu, Narcisa, Fornai, Matteo, Antonioli, Luca, Duranti, Emiliano, Daghini, Elena, Giannarelli, Chiara, Blandizzi, Corrado, Taddei, Stefano, Del Tacca, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Arterial hypertension. Arterial hypotension Atorvastatin Calcium Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Experimental diseases Heptanoic Acids - pharmacology Male Malondialdehyde - metabolism Medical sciences Mesenteric Arteries - drug effects Mesenteric Arteries - physiopathology Probability Prostaglandins - metabolism Pyrroles - pharmacology Random Allocation Rats Rats, Inbred SHR Rats, Inbred WKY Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Sensitivity and Specificity Vasodilation - drug effects Vasodilation - physiology
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