Anti-cancer and Antibacterial Trioxacarcins with High Anti-malaria Activity from a Marine Streptomycete and their Absolute Stereochemistry

The ethyl acetate extract from the Streptomyces sp. isolate B8652 delivered the trioxacarcins A-C (2a-2c) and additionally three new derivatives designated as trioxacarcins D-F (2d-2f). All trioxacarcins showed high anti-bacterial and some of them high anti-tumor and anti-malaria activity. The struc...

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Veröffentlicht in:	Journal of antibiotics 2004/12/25, Vol.57(12), pp.771-779
Hauptverfasser:	MASKEY, RAJENDRA P., HELMKE, ELISABETH, KAYSER, OLIVER, FIEBIG, HEINZ H., MAIER, ARMIN, BUSCHE, ANDREAS, LAATSCH, HARTMUT
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor Fermentation Humans Magnetic Resonance Spectroscopy Marine Biology Microbial Sensitivity Tests Stereoisomerism Streptomyces - chemistry
Online-Zugang:	Volltext
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