Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy
Background/Purpose The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin‐MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with pancreaticoduodenectomy. Methods Forty‐three patients who...
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| Veröffentlicht in: | Journal of Hepato‐Biliary‐Pancreatic Surgery 2004-01, Vol.11 (1), p.50-55 |
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| creator | Shinchi, Hiroyuki Takao, Sonshin Maemura, Kosei Fukukura, Yoshihiko Noma, Hidetoshi Matsuo, Yoichiro Mataki, Yukou Mori, Shinichiro Iino, Satoshi Ehi, Katsuhiko Aikou, Takashi |
| description | Background/Purpose
The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin‐MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with pancreaticoduodenectomy.
Methods
Forty‐three patients who had undergone pancreaticoduodenectomies and who were given pancreaticogastrostomies for reconstruction were studied. Dynamic MRCPs, using a half‐Fourier acquisition single‐shot turbo spin‐echo (HASTE) sequence were obtained before and up to 10 min after secretin administration. The morphologic features and diameter of the main pancreatic duct were monitored and graded before and after secretin stimulation. The results were compared with those of endoscopic findings, secretin stimulation testing with a collection of pancreatic fluid, N‐benzoyl‐l‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) excretion testing, and fecal chymotrypsin concentration.
Results
The results of secretin‐MRCP were classified into three distinct groups: a good‐secretion group (group 1; n = 22; 51%), a moderate‐secretion group (group 2; n = 10; 23%), and a poor‐secretion group (group 3; n = 11; 26%). This MRCP classification correlated significantly with the concentrations of the pancreatic enzymes p‐type amylase, lipase, and trypsin in the gastric juice. The BT‐PABA test value was 59.8% in group 1, 46.1% in group 2, and 46.5% in group 3, and was significantly higher in group 1 than in groups 2 or 3. The fecal chymotrypsin concentration was 20.5 U/g in group 1, 14.5 U/g in group 2, and 0.7 U/g in group 3, and there was a significant correlation between the MRCP classification and fecal chymotrypsin concentration.
Conclusions
MRCP with secretin stimulation favorably reflected the presence of remnant pancreatic exocrine function. Therefore, secretin‐MRCP is a feasible and effective follow‐up examination method to evaluate remnant pancreatic exocrine function after pancreaticogastrostomy. |
| doi_str_mv | 10.1007/s00534-003-0868-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67261407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67261407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3999-6a856c3525710ec2f939d8ac497dbb3c8a8c78380817b11ec6f950ad7e7a14b43</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxi0EokvhAbggn7gFPGvHf45QtRRUCQ7A1XK8k12jJF5sh3Yfpu-KlyyCW0_2zHzfTzP6CHkJ7A0wpt5mxlouGsZ4w7TUDTwiKzh-pNHrx2TFjBANgJRn5FnOPxgD1Wr1lJxBq1rBhFqR--9umJHGno5uO2EJnibMcXKTR-p3cXDTNsR9LRO6ErfJ7XcHehvKjmasvRImmksY58GVECday7JDir8qdulU9F97heNd9ClMSPt58n_mri-Y_pPErcslxVzieHhOnvRuyPji9J6Tb1eXXy-um5vPHz5evLtpPDfGNNLpVnrerlsFDP26N9xstPPCqE3Xca-d9kpzzTSoDgC97E3L3EahciA6wc_J64W7T_HnjLnYMWSPQ70e45ytVGsJgqkqhEXo64Y5YW_3KYwuHSwwe8zELpnYmok9ZmKhel6d4HM34uaf4xRCFchFcBsGPDxMtJ-u338xyvDf8iOdEA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67261407</pqid></control><display><type>article</type><title>Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Shinchi, Hiroyuki ; Takao, Sonshin ; Maemura, Kosei ; Fukukura, Yoshihiko ; Noma, Hidetoshi ; Matsuo, Yoichiro ; Mataki, Yukou ; Mori, Shinichiro ; Iino, Satoshi ; Ehi, Katsuhiko ; Aikou, Takashi</creator><creatorcontrib>Shinchi, Hiroyuki ; Takao, Sonshin ; Maemura, Kosei ; Fukukura, Yoshihiko ; Noma, Hidetoshi ; Matsuo, Yoichiro ; Mataki, Yukou ; Mori, Shinichiro ; Iino, Satoshi ; Ehi, Katsuhiko ; Aikou, Takashi</creatorcontrib><description>Background/Purpose
The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin‐MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with pancreaticoduodenectomy.
Methods
Forty‐three patients who had undergone pancreaticoduodenectomies and who were given pancreaticogastrostomies for reconstruction were studied. Dynamic MRCPs, using a half‐Fourier acquisition single‐shot turbo spin‐echo (HASTE) sequence were obtained before and up to 10 min after secretin administration. The morphologic features and diameter of the main pancreatic duct were monitored and graded before and after secretin stimulation. The results were compared with those of endoscopic findings, secretin stimulation testing with a collection of pancreatic fluid, N‐benzoyl‐l‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) excretion testing, and fecal chymotrypsin concentration.
Results
The results of secretin‐MRCP were classified into three distinct groups: a good‐secretion group (group 1; n = 22; 51%), a moderate‐secretion group (group 2; n = 10; 23%), and a poor‐secretion group (group 3; n = 11; 26%). This MRCP classification correlated significantly with the concentrations of the pancreatic enzymes p‐type amylase, lipase, and trypsin in the gastric juice. The BT‐PABA test value was 59.8% in group 1, 46.1% in group 2, and 46.5% in group 3, and was significantly higher in group 1 than in groups 2 or 3. The fecal chymotrypsin concentration was 20.5 U/g in group 1, 14.5 U/g in group 2, and 0.7 U/g in group 3, and there was a significant correlation between the MRCP classification and fecal chymotrypsin concentration.
Conclusions
MRCP with secretin stimulation favorably reflected the presence of remnant pancreatic exocrine function. Therefore, secretin‐MRCP is a feasible and effective follow‐up examination method to evaluate remnant pancreatic exocrine function after pancreaticogastrostomy.</description><identifier>ISSN: 0944-1166</identifier><identifier>EISSN: 1868-6982</identifier><identifier>EISSN: 1436-0691</identifier><identifier>DOI: 10.1007/s00534-003-0868-1</identifier><identifier>PMID: 15754047</identifier><language>eng</language><publisher>Japan</publisher><subject>4-Aminobenzoic Acid ; Adult ; Aged ; Aged, 80 and over ; Cholangiopancreatography, Magnetic Resonance ; Female ; Gastric Juice - enzymology ; Gastrostomy ; Humans ; Image Processing, Computer-Assisted ; magnetic resonance cholangiopancreatography ; Male ; Middle Aged ; Pancreatectomy ; pancreatic function ; Pancreaticoduodenectomy ; pancreaticogastrostomy ; para-Aminobenzoates ; Postoperative Period ; Secretin</subject><ispartof>Journal of Hepato‐Biliary‐Pancreatic Surgery, 2004-01, Vol.11 (1), p.50-55</ispartof><rights>2004 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3999-6a856c3525710ec2f939d8ac497dbb3c8a8c78380817b11ec6f950ad7e7a14b43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs00534-003-0868-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs00534-003-0868-1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15754047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinchi, Hiroyuki</creatorcontrib><creatorcontrib>Takao, Sonshin</creatorcontrib><creatorcontrib>Maemura, Kosei</creatorcontrib><creatorcontrib>Fukukura, Yoshihiko</creatorcontrib><creatorcontrib>Noma, Hidetoshi</creatorcontrib><creatorcontrib>Matsuo, Yoichiro</creatorcontrib><creatorcontrib>Mataki, Yukou</creatorcontrib><creatorcontrib>Mori, Shinichiro</creatorcontrib><creatorcontrib>Iino, Satoshi</creatorcontrib><creatorcontrib>Ehi, Katsuhiko</creatorcontrib><creatorcontrib>Aikou, Takashi</creatorcontrib><title>Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy</title><title>Journal of Hepato‐Biliary‐Pancreatic Surgery</title><addtitle>J Hepatobiliary Pancreat Surg</addtitle><description>Background/Purpose
The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin‐MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with pancreaticoduodenectomy.
Methods
Forty‐three patients who had undergone pancreaticoduodenectomies and who were given pancreaticogastrostomies for reconstruction were studied. Dynamic MRCPs, using a half‐Fourier acquisition single‐shot turbo spin‐echo (HASTE) sequence were obtained before and up to 10 min after secretin administration. The morphologic features and diameter of the main pancreatic duct were monitored and graded before and after secretin stimulation. The results were compared with those of endoscopic findings, secretin stimulation testing with a collection of pancreatic fluid, N‐benzoyl‐l‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) excretion testing, and fecal chymotrypsin concentration.
Results
The results of secretin‐MRCP were classified into three distinct groups: a good‐secretion group (group 1; n = 22; 51%), a moderate‐secretion group (group 2; n = 10; 23%), and a poor‐secretion group (group 3; n = 11; 26%). This MRCP classification correlated significantly with the concentrations of the pancreatic enzymes p‐type amylase, lipase, and trypsin in the gastric juice. The BT‐PABA test value was 59.8% in group 1, 46.1% in group 2, and 46.5% in group 3, and was significantly higher in group 1 than in groups 2 or 3. The fecal chymotrypsin concentration was 20.5 U/g in group 1, 14.5 U/g in group 2, and 0.7 U/g in group 3, and there was a significant correlation between the MRCP classification and fecal chymotrypsin concentration.
Conclusions
MRCP with secretin stimulation favorably reflected the presence of remnant pancreatic exocrine function. Therefore, secretin‐MRCP is a feasible and effective follow‐up examination method to evaluate remnant pancreatic exocrine function after pancreaticogastrostomy.</description><subject>4-Aminobenzoic Acid</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cholangiopancreatography, Magnetic Resonance</subject><subject>Female</subject><subject>Gastric Juice - enzymology</subject><subject>Gastrostomy</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>magnetic resonance cholangiopancreatography</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatectomy</subject><subject>pancreatic function</subject><subject>Pancreaticoduodenectomy</subject><subject>pancreaticogastrostomy</subject><subject>para-Aminobenzoates</subject><subject>Postoperative Period</subject><subject>Secretin</subject><issn>0944-1166</issn><issn>1868-6982</issn><issn>1436-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EokvhAbggn7gFPGvHf45QtRRUCQ7A1XK8k12jJF5sh3Yfpu-KlyyCW0_2zHzfTzP6CHkJ7A0wpt5mxlouGsZ4w7TUDTwiKzh-pNHrx2TFjBANgJRn5FnOPxgD1Wr1lJxBq1rBhFqR--9umJHGno5uO2EJnibMcXKTR-p3cXDTNsR9LRO6ErfJ7XcHehvKjmasvRImmksY58GVECday7JDir8qdulU9F97heNd9ClMSPt58n_mri-Y_pPErcslxVzieHhOnvRuyPji9J6Tb1eXXy-um5vPHz5evLtpPDfGNNLpVnrerlsFDP26N9xstPPCqE3Xca-d9kpzzTSoDgC97E3L3EahciA6wc_J64W7T_HnjLnYMWSPQ70e45ytVGsJgqkqhEXo64Y5YW_3KYwuHSwwe8zELpnYmok9ZmKhel6d4HM34uaf4xRCFchFcBsGPDxMtJ-u338xyvDf8iOdEA</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Shinchi, Hiroyuki</creator><creator>Takao, Sonshin</creator><creator>Maemura, Kosei</creator><creator>Fukukura, Yoshihiko</creator><creator>Noma, Hidetoshi</creator><creator>Matsuo, Yoichiro</creator><creator>Mataki, Yukou</creator><creator>Mori, Shinichiro</creator><creator>Iino, Satoshi</creator><creator>Ehi, Katsuhiko</creator><creator>Aikou, Takashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy</title><author>Shinchi, Hiroyuki ; Takao, Sonshin ; Maemura, Kosei ; Fukukura, Yoshihiko ; Noma, Hidetoshi ; Matsuo, Yoichiro ; Mataki, Yukou ; Mori, Shinichiro ; Iino, Satoshi ; Ehi, Katsuhiko ; Aikou, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3999-6a856c3525710ec2f939d8ac497dbb3c8a8c78380817b11ec6f950ad7e7a14b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>4-Aminobenzoic Acid</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cholangiopancreatography, Magnetic Resonance</topic><topic>Female</topic><topic>Gastric Juice - enzymology</topic><topic>Gastrostomy</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>magnetic resonance cholangiopancreatography</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatectomy</topic><topic>pancreatic function</topic><topic>Pancreaticoduodenectomy</topic><topic>pancreaticogastrostomy</topic><topic>para-Aminobenzoates</topic><topic>Postoperative Period</topic><topic>Secretin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinchi, Hiroyuki</creatorcontrib><creatorcontrib>Takao, Sonshin</creatorcontrib><creatorcontrib>Maemura, Kosei</creatorcontrib><creatorcontrib>Fukukura, Yoshihiko</creatorcontrib><creatorcontrib>Noma, Hidetoshi</creatorcontrib><creatorcontrib>Matsuo, Yoichiro</creatorcontrib><creatorcontrib>Mataki, Yukou</creatorcontrib><creatorcontrib>Mori, Shinichiro</creatorcontrib><creatorcontrib>Iino, Satoshi</creatorcontrib><creatorcontrib>Ehi, Katsuhiko</creatorcontrib><creatorcontrib>Aikou, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Hepato‐Biliary‐Pancreatic Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinchi, Hiroyuki</au><au>Takao, Sonshin</au><au>Maemura, Kosei</au><au>Fukukura, Yoshihiko</au><au>Noma, Hidetoshi</au><au>Matsuo, Yoichiro</au><au>Mataki, Yukou</au><au>Mori, Shinichiro</au><au>Iino, Satoshi</au><au>Ehi, Katsuhiko</au><au>Aikou, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy</atitle><jtitle>Journal of Hepato‐Biliary‐Pancreatic Surgery</jtitle><addtitle>J Hepatobiliary Pancreat Surg</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>11</volume><issue>1</issue><spage>50</spage><epage>55</epage><pages>50-55</pages><issn>0944-1166</issn><eissn>1868-6982</eissn><eissn>1436-0691</eissn><abstract>Background/Purpose
The aim of this study was to assess the value of magnetic resonance cholangiopancreatography with secretin stimulation (secretin‐MRCP) in evaluating the remnant pancreatic exocrine reserve after pancreaticogastrostomy with pancreaticoduodenectomy.
Methods
Forty‐three patients who had undergone pancreaticoduodenectomies and who were given pancreaticogastrostomies for reconstruction were studied. Dynamic MRCPs, using a half‐Fourier acquisition single‐shot turbo spin‐echo (HASTE) sequence were obtained before and up to 10 min after secretin administration. The morphologic features and diameter of the main pancreatic duct were monitored and graded before and after secretin stimulation. The results were compared with those of endoscopic findings, secretin stimulation testing with a collection of pancreatic fluid, N‐benzoyl‐l‐tyrosyl‐p‐aminobenzoic acid (BT‐PABA) excretion testing, and fecal chymotrypsin concentration.
Results
The results of secretin‐MRCP were classified into three distinct groups: a good‐secretion group (group 1; n = 22; 51%), a moderate‐secretion group (group 2; n = 10; 23%), and a poor‐secretion group (group 3; n = 11; 26%). This MRCP classification correlated significantly with the concentrations of the pancreatic enzymes p‐type amylase, lipase, and trypsin in the gastric juice. The BT‐PABA test value was 59.8% in group 1, 46.1% in group 2, and 46.5% in group 3, and was significantly higher in group 1 than in groups 2 or 3. The fecal chymotrypsin concentration was 20.5 U/g in group 1, 14.5 U/g in group 2, and 0.7 U/g in group 3, and there was a significant correlation between the MRCP classification and fecal chymotrypsin concentration.
Conclusions
MRCP with secretin stimulation favorably reflected the presence of remnant pancreatic exocrine function. Therefore, secretin‐MRCP is a feasible and effective follow‐up examination method to evaluate remnant pancreatic exocrine function after pancreaticogastrostomy.</abstract><cop>Japan</cop><pmid>15754047</pmid><doi>10.1007/s00534-003-0868-1</doi><tpages>6</tpages></addata></record> |
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| subjects | 4-Aminobenzoic Acid Adult Aged Aged, 80 and over Cholangiopancreatography, Magnetic Resonance Female Gastric Juice - enzymology Gastrostomy Humans Image Processing, Computer-Assisted magnetic resonance cholangiopancreatography Male Middle Aged Pancreatectomy pancreatic function Pancreaticoduodenectomy pancreaticogastrostomy para-Aminobenzoates Postoperative Period Secretin |
| title | Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy |
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