SOX2 Silencing in Glioblastoma Tumor‐Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity
Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self‐renewal of several stem cells, in particular neural stem cells. To investigate its rol...
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| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2009-01, Vol.27 (1), p.40-48 |
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| container_title | Stem cells (Dayton, Ohio) |
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| creator | Gangemi, Rosaria Maria Rita Griffero, Fabrizio Marubbi, Daniela Perera, Marzia Capra, Maria Cristina Malatesta, Paolo Ravetti, Gian Luigi Zona, Gian Luigi Daga, Antonio Corte, Giorgio |
| description | Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self‐renewal of several stem cells, in particular neural stem cells. To investigate its role in the aberrant growth of glioblastoma, we silenced SOX2 in freshly derived glioblastoma tumor‐initiating cells (TICs). Our results indicate that SOX2 silenced glioblastoma TICs, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. SOX2 is then also fundamental for maintenance of the self‐renewal capacity of neural stem cells when they have acquired cancer properties. SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy. STEM CELLS 2009;27:40–48 |
| doi_str_mv | 10.1634/stemcells.2008-0493 |
| format | Article |
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Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self‐renewal of several stem cells, in particular neural stem cells. To investigate its role in the aberrant growth of glioblastoma, we silenced SOX2 in freshly derived glioblastoma tumor‐initiating cells (TICs). Our results indicate that SOX2 silenced glioblastoma TICs, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. SOX2 is then also fundamental for maintenance of the self‐renewal capacity of neural stem cells when they have acquired cancer properties. SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy. STEM CELLS 2009;27:40–48</description><identifier>ISSN: 1066-5099</identifier><identifier>EISSN: 1549-4918</identifier><identifier>DOI: 10.1634/stemcells.2008-0493</identifier><identifier>PMID: 18948646</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Animals ; Cell Lineage ; Cell Proliferation ; Clone Cells ; Gene Silencing ; Glioblastoma ; Glioblastoma - genetics ; Glioblastoma - pathology ; Humans ; Ki-67 Antigen - metabolism ; Mice ; Mice, SCID ; MicroRNAs - metabolism ; Neoplastic Stem Cells - metabolism ; Neoplastic Stem Cells - pathology ; Phenotype ; SOX2 gene silencing ; SOXB1 Transcription Factors - genetics ; Tumor Stem Cell Assay ; Tumorigenesis ; Tumor‐initiating cells</subject><ispartof>Stem cells (Dayton, Ohio), 2009-01, Vol.27 (1), p.40-48</ispartof><rights>Copyright © 2008 AlphaMed Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4683-54727fe6641f969b4af4815ccb3d59969a60b48baaed236d08c9529bc9e6f2423</citedby><cites>FETCH-LOGICAL-c4683-54727fe6641f969b4af4815ccb3d59969a60b48baaed236d08c9529bc9e6f2423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18948646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gangemi, Rosaria Maria Rita</creatorcontrib><creatorcontrib>Griffero, Fabrizio</creatorcontrib><creatorcontrib>Marubbi, Daniela</creatorcontrib><creatorcontrib>Perera, Marzia</creatorcontrib><creatorcontrib>Capra, Maria Cristina</creatorcontrib><creatorcontrib>Malatesta, Paolo</creatorcontrib><creatorcontrib>Ravetti, Gian Luigi</creatorcontrib><creatorcontrib>Zona, Gian Luigi</creatorcontrib><creatorcontrib>Daga, Antonio</creatorcontrib><creatorcontrib>Corte, Giorgio</creatorcontrib><title>SOX2 Silencing in Glioblastoma Tumor‐Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity</title><title>Stem cells (Dayton, Ohio)</title><addtitle>Stem Cells</addtitle><description>Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self‐renewal of several stem cells, in particular neural stem cells. To investigate its role in the aberrant growth of glioblastoma, we silenced SOX2 in freshly derived glioblastoma tumor‐initiating cells (TICs). Our results indicate that SOX2 silenced glioblastoma TICs, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. SOX2 is then also fundamental for maintenance of the self‐renewal capacity of neural stem cells when they have acquired cancer properties. SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy. STEM CELLS 2009;27:40–48</description><subject>Adult</subject><subject>Animals</subject><subject>Cell Lineage</subject><subject>Cell Proliferation</subject><subject>Clone Cells</subject><subject>Gene Silencing</subject><subject>Glioblastoma</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>MicroRNAs - metabolism</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Phenotype</subject><subject>SOX2 gene silencing</subject><subject>SOXB1 Transcription Factors - genetics</subject><subject>Tumor Stem Cell Assay</subject><subject>Tumorigenesis</subject><subject>Tumor‐initiating cells</subject><issn>1066-5099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkN9KwzAUh4Mobv55AkFy5V1n0qZZcuGFjDkHkwmd4F1I03RE2mQ2LbI7H8Fn9ElstqG3XuUk5zu_Ez4ArjAaYZqQW9_qWumq8qMYIRYhwpMjMMQp4RHhmB33NaI0ShHnA3Dm_RtCmKSMnYIBZpwwSugQuGz5GsPMVNoqY9fQWDirjMsr6VtXS7jqatd8f37NrWmNbAMyCTvhRHZee5i1bgNdCZ8bV5lSNz3iLJS2gAvnfejsEsxaW6NMu70AJ6WsvL48nOfg5WG6mjxGi-VsPrlfRIpQlkQpGcfjUlNKcMkpz4ksCcOpUnlSpLx_kRTlhOVS6iJOaIGY4mnMc8U1LWMSJ-fgZp-7adx7p30rauODLWm167yg45hinAQw2YOq6T_c6FJsGlPLZiswEsGz-PUsgmcRPPdT14f4Lq918TdzENsDd3vgo1e7_U-myFbTp3DbLfgBB2mRJg</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Gangemi, Rosaria Maria Rita</creator><creator>Griffero, Fabrizio</creator><creator>Marubbi, Daniela</creator><creator>Perera, Marzia</creator><creator>Capra, Maria Cristina</creator><creator>Malatesta, Paolo</creator><creator>Ravetti, Gian Luigi</creator><creator>Zona, Gian Luigi</creator><creator>Daga, Antonio</creator><creator>Corte, Giorgio</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200901</creationdate><title>SOX2 Silencing in Glioblastoma Tumor‐Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity</title><author>Gangemi, Rosaria Maria Rita ; 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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Animals Cell Lineage Cell Proliferation Clone Cells Gene Silencing Glioblastoma Glioblastoma - genetics Glioblastoma - pathology Humans Ki-67 Antigen - metabolism Mice Mice, SCID MicroRNAs - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phenotype SOX2 gene silencing SOXB1 Transcription Factors - genetics Tumor Stem Cell Assay Tumorigenesis Tumor‐initiating cells |
| title | SOX2 Silencing in Glioblastoma Tumor‐Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity |
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