Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease
Interleukin-18 (IL-18) is a proinflammatory cytokine released by macrophages that strongly stimulates the production of interferon-γ, thereby linking innate and acquired immunity. Its role in human immunodeficiency virus (HIV) pathogenesis is under debate and little is known about its role in neuro-...
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| Veröffentlicht in: | Journal of neurovirology 2004-12, Vol.10 (6), p.383-386 |
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| creator | Giesen, Hans-Jürgen von Jander, Sebastian Köller, Hubertus Arendt, Gabriele |
| description | Interleukin-18 (IL-18) is a proinflammatory cytokine released by macrophages that strongly stimulates the production of interferon-γ, thereby linking innate and acquired immunity. Its role in human immunodeficiency virus (HIV) pathogenesis is under debate and little is known about its role in neuro-AIDS (acquired immunodeficiency syndrome). Serum and cerebrospinal fluid (CSF) levels of IL-18 were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) in 22 HIV-seropositive patients without neurological symptoms (HIV+), 21 patients with AIDS dementia complex (ADC), and 31 patients with AIDS-defining opportunistic infections (OIs) of the brain. Thirty-two HIV seronegative patients (HIV−) served as controls. Compared to HIV− controls, serum IL-18 levels were increased in HIV+ and ADC but not in OI patients. In contrast, CSF IL-18 levels were elevated in OI patients whereas HIV+ and ADC patients were not different from HIV− controls. We provide evidence for an significantly increased IL-18 level in the CSF of HIV+ patients with cerebral OIs, suggestive of a role for IL-18 in the intrathecal host response to OIs. |
| doi_str_mv | 10.1080/13550280490523706 |
| format | Article |
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Its role in human immunodeficiency virus (HIV) pathogenesis is under debate and little is known about its role in neuro-AIDS (acquired immunodeficiency syndrome). Serum and cerebrospinal fluid (CSF) levels of IL-18 were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) in 22 HIV-seropositive patients without neurological symptoms (HIV+), 21 patients with AIDS dementia complex (ADC), and 31 patients with AIDS-defining opportunistic infections (OIs) of the brain. Thirty-two HIV seronegative patients (HIV−) served as controls. Compared to HIV− controls, serum IL-18 levels were increased in HIV+ and ADC but not in OI patients. In contrast, CSF IL-18 levels were elevated in OI patients whereas HIV+ and ADC patients were not different from HIV− controls. We provide evidence for an significantly increased IL-18 level in the CSF of HIV+ patients with cerebral OIs, suggestive of a role for IL-18 in the intrathecal host response to OIs.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.1080/13550280490523706</identifier><identifier>PMID: 15765809</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - cerebrospinal fluid ; Adult ; AIDS Dementia Complex - blood ; AIDS Dementia Complex - cerebrospinal fluid ; AIDS-Related Opportunistic Infections - blood ; AIDS-Related Opportunistic Infections - cerebrospinal fluid ; Biological and medical sciences ; Central Nervous System Infections - blood ; Central Nervous System Infections - cerebrospinal fluid ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV-1 - immunology ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Interleukin-18 - analysis ; Male ; Medical sciences ; Middle Aged ; Neurology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral diseases of the nervous system</subject><ispartof>Journal of neurovirology, 2004-12, Vol.10 (6), p.383-386</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-755ed2a35ea9111f4b2903f1c59a7e457e55bda3be368a9c8e471829689f762a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/13550280490523706$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/13550280490523706$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,61220,61401</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16335879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15765809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giesen, Hans-Jürgen von</creatorcontrib><creatorcontrib>Jander, Sebastian</creatorcontrib><creatorcontrib>Köller, Hubertus</creatorcontrib><creatorcontrib>Arendt, Gabriele</creatorcontrib><title>Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease</title><title>Journal of neurovirology</title><addtitle>J Neurovirol</addtitle><description>Interleukin-18 (IL-18) is a proinflammatory cytokine released by macrophages that strongly stimulates the production of interferon-γ, thereby linking innate and acquired immunity. Its role in human immunodeficiency virus (HIV) pathogenesis is under debate and little is known about its role in neuro-AIDS (acquired immunodeficiency syndrome). Serum and cerebrospinal fluid (CSF) levels of IL-18 were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) in 22 HIV-seropositive patients without neurological symptoms (HIV+), 21 patients with AIDS dementia complex (ADC), and 31 patients with AIDS-defining opportunistic infections (OIs) of the brain. Thirty-two HIV seronegative patients (HIV−) served as controls. Compared to HIV− controls, serum IL-18 levels were increased in HIV+ and ADC but not in OI patients. In contrast, CSF IL-18 levels were elevated in OI patients whereas HIV+ and ADC patients were not different from HIV− controls. We provide evidence for an significantly increased IL-18 level in the CSF of HIV+ patients with cerebral OIs, suggestive of a role for IL-18 in the intrathecal host response to OIs.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - cerebrospinal fluid</subject><subject>Adult</subject><subject>AIDS Dementia Complex - blood</subject><subject>AIDS Dementia Complex - cerebrospinal fluid</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS-Related Opportunistic Infections - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Infections - blood</subject><subject>Central Nervous System Infections - cerebrospinal fluid</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interleukin-18 - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral diseases of the nervous system</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhgdRbK3-ADeSjd2NJpPJF66ktLZQcGFdD2cyJ9zUTOaaTC7cX-Dfbi73QheCrpKQ5304nLdp3jP6iVFNPzMuBO007Q0VHVdUvmjOmeC67fqev6z3-t9WoD9r3uT8SCnjstOvmzMmlBSamvPmzw9MZSYQJ2Ix4ZiWvPURAnGh-IkE3GHIZHHExxVTwPLLx5bp-iSbMkMkfp5LXCZ03nqMdk92PpVM1v0WCWsh58V6WPGgj2uq4ohpt1Qi7_OKM5l8Rsj4tnnlIGR8dzovmp831w9Xt-399293V1_vW9uzbm2VEDh1wAWCYYy5fuwM5Y5ZYUBhLxQKMU7AR-RSg7Eae8V0Z6Q2TskavGguj95tWn4XzOsw-2wxBIhYpxqk6iTV1fk_kCktemNkBdkRtHV3OaEbtsnPkPYDo8OhpuGvmmrmw0lexhmn58Splwp8PAGQLQSXIFqfnznJudDqwH05cj66Jc2wQQjrxkLC4XEpqRaZ_zHGE6E7rnc</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Giesen, Hans-Jürgen von</creator><creator>Jander, Sebastian</creator><creator>Köller, Hubertus</creator><creator>Arendt, Gabriele</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease</title><author>Giesen, Hans-Jürgen von ; Jander, Sebastian ; Köller, Hubertus ; Arendt, Gabriele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-755ed2a35ea9111f4b2903f1c59a7e457e55bda3be368a9c8e471829689f762a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - cerebrospinal fluid</topic><topic>Adult</topic><topic>AIDS Dementia Complex - blood</topic><topic>AIDS Dementia Complex - cerebrospinal fluid</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS-Related Opportunistic Infections - cerebrospinal fluid</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Infections - blood</topic><topic>Central Nervous System Infections - cerebrospinal fluid</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>HIV-1 - immunology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interleukin-18 - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giesen, Hans-Jürgen von</creatorcontrib><creatorcontrib>Jander, Sebastian</creatorcontrib><creatorcontrib>Köller, Hubertus</creatorcontrib><creatorcontrib>Arendt, Gabriele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giesen, Hans-Jürgen von</au><au>Jander, Sebastian</au><au>Köller, Hubertus</au><au>Arendt, Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease</atitle><jtitle>Journal of neurovirology</jtitle><addtitle>J Neurovirol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>10</volume><issue>6</issue><spage>383</spage><epage>386</epage><pages>383-386</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>Interleukin-18 (IL-18) is a proinflammatory cytokine released by macrophages that strongly stimulates the production of interferon-γ, thereby linking innate and acquired immunity. Its role in human immunodeficiency virus (HIV) pathogenesis is under debate and little is known about its role in neuro-AIDS (acquired immunodeficiency syndrome). Serum and cerebrospinal fluid (CSF) levels of IL-18 were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) in 22 HIV-seropositive patients without neurological symptoms (HIV+), 21 patients with AIDS dementia complex (ADC), and 31 patients with AIDS-defining opportunistic infections (OIs) of the brain. Thirty-two HIV seronegative patients (HIV−) served as controls. Compared to HIV− controls, serum IL-18 levels were increased in HIV+ and ADC but not in OI patients. In contrast, CSF IL-18 levels were elevated in OI patients whereas HIV+ and ADC patients were not different from HIV− controls. 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| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - cerebrospinal fluid Adult AIDS Dementia Complex - blood AIDS Dementia Complex - cerebrospinal fluid AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - cerebrospinal fluid Biological and medical sciences Central Nervous System Infections - blood Central Nervous System Infections - cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Enzyme-Linked Immunosorbent Assay Female HIV-1 - immunology Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Interleukin-18 - analysis Male Medical sciences Middle Aged Neurology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral diseases of the nervous system |
| title | Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease |
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