Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia

Abstract Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter ( P = 0.038) treatment free survival. Culture of CLL cells with...

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Veröffentlicht in:	Leukemia research 2009-08, Vol.33 (8), p.1089-1095
Hauptverfasser:	Hock, B.D, Fernyhough, L.J, Gough, S.M, Steinkasserer, A, Cox, A.G, McKenzie, J.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antigens, CD - blood Antigens, CD - immunology CD83 CD83 Antigen Chronic Disease Chronic lymphocytic leukemia Disease-Free Survival Female Hematology, Oncology and Palliative Medicine Humans Immunoglobulins - blood Immunoglobulins - immunology Interleukin-4 - immunology Interleukin-4 - pharmacology Leukemia, Lymphoid - blood Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - immunology Leukemia, Lymphoid - mortality Male Membrane Glycoproteins - blood Membrane Glycoproteins - immunology Middle Aged Neoplasm Proteins - blood Neoplasm Proteins - immunology Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - blood RNA, Messenger - immunology RNA, Neoplasm - blood RNA, Neoplasm - immunology Soluble Survival Rate Tumor Cells, Cultured
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