Selection of Molecular Structure and Delivery of RNA Oligonucleotides to Activate TLR7 versus TLR8 and to Induce High Amounts of IL-12p70 in Primary Human Monocytes

Detection of non-self RNA by TLRs within endosomes and by retinoic acid-inducible gene I (RIG-I)-like helicases in the cytosol is central to mammalian antiviral immunity. In this study, we used pathway-specific agonists and targeted delivery to address RNA immunorecognition in primary human immune c...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-06, Vol.182 (11), p.6824-6833
Hauptverfasser:	Ablasser, Andrea, Poeck, Hendrik, Anz, David, Berger, Michael, Schlee, Martin, Kim, Sarah, Bourquin, Carole, Goutagny, Nadege, Jiang, Zhaozhao, Fitzgerald, Katherine A, Rothenfusser, Simon, Endres, Stefan, Hartmann, Gunther, Hornung, Veit
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured DEAD Box Protein 58 DEAD-box RNA Helicases - physiology Dendritic Cells - immunology Humans Interferon-alpha - biosynthesis Interleukin-12 - biosynthesis Monocytes - immunology Oligoribonucleotides - immunology Oligoribonucleotides - pharmacology Receptors, Immunologic RNA - immunology RNA - pharmacology Toll-Like Receptor 7 - drug effects Toll-Like Receptor 8 - drug effects
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