Regulation of Expression and Activity of Rat Intestinal Multidrug Resistance-Associated Protein 2 by Cholestatic Estrogens

The effect of the cholestatic estrogens ethynylestradiol (EE) and estradiol 17β-d-glucuronide (E2-17G) on expression and activity of intestinal multidrug resistant-associated protein 2 (Mrp2, Abcc2) was studied in rats. Expression and localization of Mrp2 were evaluated by Western blotting, real-tim...

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Veröffentlicht in:	Drug metabolism and disposition 2009-06, Vol.37 (6), p.1277-1285
Hauptverfasser:	Arias, Agostina, Villanueva, Silvina S.M., Ruiz, María L., Luquita, Marcelo G., Veggi, Luis M., Pellegrino, José M., Vore, Mary, Catania, Viviana A., Mottino, Aldo D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Biological Transport, Active - drug effects Biomarkers - metabolism Body Weight - drug effects Cholestasis - metabolism Down-Regulation - drug effects Estradiol - analogs & derivatives Estradiol - pharmacology Estrogens - pharmacology Gene Expression - drug effects Intestines - metabolism Male Medical sciences Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Pharmacology. Drug treatments Rats Rats, Wistar
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