Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization

Human hepatocellular carcinoma (HCC) remains incurable with current therapies, and novel biologically based therapies are urgently needed. Arsenic agents have long been used as anticancer agents in traditional Chinese medicine. In this study, to evaluate the effect of As 2 O 3 on HCC cells, we inves...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) London, England), 2009-06, Vol.26 (2), p.178-185
Hauptverfasser:	Fei, Min, Lu, Mudan, Wang, You, Zhao, Yueming, He, Song, Gao, Shangfeng, Ke, Qing, Liu, Yonghua, Li, Peng, Cui, Xiaopeng, Shen, Aiguo, Cheng, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Antineoplastic Agents - therapeutic use Arsenicals - therapeutic use Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Forkhead Box Protein O3 Forkhead Transcription Factors - analysis Forkhead Transcription Factors - metabolism Hematology Humans Internal Medicine Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - metabolism Medicine Medicine & Public Health Metabolic Networks and Pathways - drug effects Oncology Original Paper Oxides - therapeutic use Pathology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism
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