New Bone Formation by Allogeneic Mesenchymal Stem Cell Transplantation in a Patient with Perinatal Hypophosphatasia

Mesenchymal stem cells (MSCs) can show osteogenic differentiation capability when implanted in vivo, as well as cultured in vitro; therefore we attempted to use allogeneic MSCs for an 8-month-old patient with hypophosphatasia. MSCs were obtained by culture expansion of fresh marrow from the patient&...

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Veröffentlicht in:	The Journal of pediatrics 2009-06, Vol.154 (6), p.924-930
Hauptverfasser:	Tadokoro, Mika, BS, Kanai, Rie, MD, Taketani, Takeshi, MD, Uchio, Yuji, MD, Yamaguchi, Seiji, MD, Ohgushi, Hajime, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - blood Biological and medical sciences Bone Density Cell Differentiation Cells, Cultured Errors of metabolism Female General aspects Humans Hypophosphatasia - metabolism Hypophosphatasia - physiopathology Hypophosphatasia - therapy Infant Infusions, Intraosseous Infusions, Intravenous Medical sciences Mesenchymal Stem Cell Transplantation Metabolic diseases Miscellaneous hereditary metabolic disorders Osteoblasts - transplantation Osteogenesis Pediatrics Respiration, Artificial Tissue Engineering Transplantation, Homologous
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