Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity. Here, we report that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TR...

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Veröffentlicht in:	Cell host & microbe 2009-05, Vol.5 (5), p.439-449
Hauptverfasser:	Gack, Michaela Ulrike, Albrecht, Randy Allen, Urano, Tomohiko, Inn, Kyung-Soo, Huang, I-Chueh, Carnero, Elena, Farzan, Michael, Inoue, Satoshi, Jung, Jae Ung, García-Sastre, Adolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Female Host-Pathogen Interactions Humans Influenza A virus - chemistry Influenza A virus - genetics Influenza A virus - metabolism Influenza, Human - immunology Influenza, Human - metabolism Influenza, Human - virology Interferon Type I - immunology Mice Mice, Inbred BALB C Protein Binding Protein Structure, Tertiary Protein Transport Receptors, Immunologic Signal Transduction Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Tripartite Motif Proteins Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism
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