Modulation of luciferase activity using high intensity focused ultrasound in combination with bioluminescence imaging, magnetic resonance imaging and histological analysis in muscle tissue

This study investigates the effect of high intensity focused ultrasound (HIFU) to muscle tissue transfected with a luciferase reporter gene under the control of a CMV-promoter. HIFU was applied to the transfected muscle tissue using a dual HIFU system. In a first group four different intensities (80...

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Veröffentlicht in:	Ultrasonics 2009-06, Vol.49 (6), p.549-557
Hauptverfasser:	Hundt, Walter, Steinbach, Silke, Mayer, Dirk, Bednarski, Mark D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Contrast Media Fundamental and applied biological sciences. Psychology Gadolinium DTPA Gene therapy Health. Pharmaceutical industry High intensity focused ultrasound Histology Image Processing, Computer-Assisted Industrial applications and implications. Economical aspects Luciferase activity Luciferases - genetics Luciferases - metabolism Luminescent Measurements Magnetic Resonance Imaging Medical sciences Mice Mice, Inbred BALB C MRI Muscle tissue Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Statistics, Nonparametric Technology. Biomaterials. Equipments. Material. Instrumentation Transducers Ultrasonic Therapy - instrumentation
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