In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights
Sphingosine 1-phosphate (S1P), a biologically active lipid growth factor, induces robust endothelial cell activation resulting in cellular locomotion, vascular maturation and angiogenesis. Recent work by our laboratory has demonstrated S1P to enhance the cellular barrier function of the vascular end...
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| Veröffentlicht in: | Cellular signalling 2005-02, Vol.17 (2), p.131-139 |
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| creator | McVerry, Bryan J. Garcia, Joe G.N. |
| description | Sphingosine 1-phosphate (S1P), a biologically active lipid growth factor, induces robust endothelial cell activation resulting in cellular locomotion, vascular maturation and angiogenesis. Recent work by our laboratory has demonstrated S1P to enhance the cellular barrier function of the vascular endothelium. S1P-induced modulation of vascular permeability is effected through profound cytoskeletal reorganization initiated by cell surface receptor-mediated G protein activation and downstream signaling via the Rho family of small GTPases. The details of the downstream signaling mechanism remain an active area of in vitro investigation. Translational investigation suggests a profound impact of S1P administration in the modulation of edema formation in disease state manifest as acute inflammatory lung injury in which increased vascular permeability is a hallmark feature. These data support an exciting potential therapeutic role for S1P in vascular barrier enhancement necessary for the treatment of critically ill patients. |
| doi_str_mv | 10.1016/j.cellsig.2004.08.006 |
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Garcia, Joe G.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-7e7ae6d58f6ec20504b8200c8b1513e3faacb66a8dff6704e3114c7323cf6c5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adherens Junctions - drug effects</topic><topic>Adherens Junctions - metabolism</topic><topic>Adherens Junctions - physiology</topic><topic>Angiogenesis Inducing Agents - metabolism</topic><topic>Angiogenesis Inducing Agents - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Cadherin</topic><topic>Capillary Permeability - drug effects</topic><topic>Capillary Permeability - physiology</topic><topic>Cortactin</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - drug effects</topic><topic>Cytoskeleton - metabolism</topic><topic>Cytoskeleton - physiology</topic><topic>Endothelial permeability</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiology</topic><topic>Extracellular Matrix - drug effects</topic><topic>Extracellular Matrix - metabolism</topic><topic>Extracellular Matrix - physiology</topic><topic>Focal Adhesions - drug effects</topic><topic>Focal Adhesions - metabolism</topic><topic>Focal Adhesions - physiology</topic><topic>Humans</topic><topic>Lysophospholipids - pharmacology</topic><topic>Lysophospholipids - physiology</topic><topic>Lysophospholipids - therapeutic use</topic><topic>MLCK</topic><topic>Models, Biological</topic><topic>rac GTP-Binding Proteins - physiology</topic><topic>Rac GTPase</topic><topic>Respiratory Distress Syndrome, Adult - drug therapy</topic><topic>Respiratory Distress Syndrome, Adult - physiopathology</topic><topic>Rho GTPase</topic><topic>Signal Transduction - physiology</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - pharmacology</topic><topic>Sphingosine - physiology</topic><topic>Sphingosine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McVerry, Bryan J.</creatorcontrib><creatorcontrib>Garcia, Joe G.N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McVerry, Bryan J.</au><au>Garcia, Joe G.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights</atitle><jtitle>Cellular signalling</jtitle><addtitle>Cell Signal</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>17</volume><issue>2</issue><spage>131</spage><epage>139</epage><pages>131-139</pages><issn>0898-6568</issn><eissn>1873-3913</eissn><abstract>Sphingosine 1-phosphate (S1P), a biologically active lipid growth factor, induces robust endothelial cell activation resulting in cellular locomotion, vascular maturation and angiogenesis. Recent work by our laboratory has demonstrated S1P to enhance the cellular barrier function of the vascular endothelium. S1P-induced modulation of vascular permeability is effected through profound cytoskeletal reorganization initiated by cell surface receptor-mediated G protein activation and downstream signaling via the Rho family of small GTPases. The details of the downstream signaling mechanism remain an active area of in vitro investigation. Translational investigation suggests a profound impact of S1P administration in the modulation of edema formation in disease state manifest as acute inflammatory lung injury in which increased vascular permeability is a hallmark feature. These data support an exciting potential therapeutic role for S1P in vascular barrier enhancement necessary for the treatment of critically ill patients.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>15494205</pmid><doi>10.1016/j.cellsig.2004.08.006</doi><tpages>9</tpages></addata></record> |
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| subjects | Adherens Junctions - drug effects Adherens Junctions - metabolism Adherens Junctions - physiology Angiogenesis Inducing Agents - metabolism Angiogenesis Inducing Agents - pharmacology Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Cadherin Capillary Permeability - drug effects Capillary Permeability - physiology Cortactin Cytoskeleton Cytoskeleton - drug effects Cytoskeleton - metabolism Cytoskeleton - physiology Endothelial permeability Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - physiology Focal Adhesions - drug effects Focal Adhesions - metabolism Focal Adhesions - physiology Humans Lysophospholipids - pharmacology Lysophospholipids - physiology Lysophospholipids - therapeutic use MLCK Models, Biological rac GTP-Binding Proteins - physiology Rac GTPase Respiratory Distress Syndrome, Adult - drug therapy Respiratory Distress Syndrome, Adult - physiopathology Rho GTPase Signal Transduction - physiology Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine - physiology Sphingosine - therapeutic use |
| title | In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights |
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