Two G protein-coupled receptors activate Na +/H + exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway

The sodium hydrogen exchanger isoform 1 (NHE1) is present in nearly all cells. Regulation of proton flux via the exchanger is a permissive step in cell growth and tumorgenesis and is vital in control of cell volume. The regulation of NHE1 by growth factors involves the Ras-extracellular signal regul...

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Veröffentlicht in:	Cellular signalling 2005-02, Vol.17 (2), p.231-242
Hauptverfasser:	Wallert, M.A., Thronson, H.L., Korpi, N.L., Olmschenk, S.M., McCoy, A.C., Funfar, M.R., Provost, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha adrenergic receptor Amides - pharmacology Animals Butadienes - pharmacology Cricetinae Cricetulus Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology ERK Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - physiology Flavonoids - pharmacology Hydrogen-Ion Concentration - drug effects Intracellular Signaling Peptides and Proteins Lysophosphatidic acid Lysophospholipids - pharmacology MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - genetics MAP Kinase Kinase 1 - metabolism Nitriles - pharmacology Phenylephrine Phenylephrine - pharmacology Phosphorylation - drug effects Protein Isoforms - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - physiology Pyridines - pharmacology Receptors, Adrenergic, alpha - physiology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - physiology rho-Associated Kinases Signal Transduction - drug effects Signal Transduction - physiology Sodium hydrogen exchanger Sodium-Hydrogen Exchangers - metabolism Transfection
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