Micronization of atorvastatin calcium by antisolvent precipitation process

Amorphous atorvastatin calcium (AC) ultrafine powder has been successfully prepared by antisolvent precipitation and spray drying process, in which hydroxypropyl methylcellulose (HPMC) was employed to control the particle size and morphology. The effects of experimental parameters, such as stirring...

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Veröffentlicht in:	International journal of pharmaceutics 2009-06, Vol.374 (1), p.106-113
Hauptverfasser:	Zhang, Hai-Xia, Wang, Jie-Xin, Zhang, Zhi-Bing, Le, Yuan, Shen, Zhi-Gang, Chen, Jian-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisolvent precipitation Atorvastatin Calcium Biological and medical sciences Chemical Precipitation Chemistry, Pharmaceutical Excipients - chemistry General pharmacology Heptanoic Acids - chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry Hypromellose Derivatives Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poorly water-soluble drug Powders Pyrroles - chemistry Solubility Solvents - chemistry Time Factors Ultrafine particle X-Ray Diffraction
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